| |  Online-Ressource |
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| Verfasst von: | Liew, Hans [VerfasserIn]  |
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| | Mein, Stewart [VerfasserIn] |
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| | Tessonnier, Thomas [VerfasserIn] |
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| | Abdollahi, Amir [VerfasserIn] |
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| | Debus, Jürgen [VerfasserIn] |
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| | Dokić, Ivana [VerfasserIn] |
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| | Mairani, Andrea [VerfasserIn] |
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| Titel: | Do we preserve Tumor Control Probability (TCP) in FLASH radiotherapy? |
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| Titelzusatz: | a model-based analysis |
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| Verf.angabe: | Hans Liew, Stewart Mein, Thomas Tessonnier, Amir Abdollahi, Jürgen Debus, Ivana Dokic and Andrea Mairani |
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| E-Jahr: | 2023 |
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| Jahr: | 7 March 2023 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 25.04.2023 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 24(2023), 6 vom: März, Artikel-ID 5118, Seite 1-12 |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Reports of concurrent sparing of normal tissue and iso-effective treatment of tumors at ultra-high dose-rates (uHDR) have fueled the growing field of FLASH radiotherapy. However, iso-effectiveness in tumors is often deduced from the absence of a significant difference in their growth kinetics. In a model-based analysis, we investigate the meaningfulness of these indications for the clinical treatment outcome. The predictions of a previously benchmarked model of uHDR sparing in the “UNIfied and VERSatile bio response Engine” (UNIVERSE) are combined with existing models of tumor volume kinetics as well as tumor control probability (TCP) and compared to experimental data. The potential TCP of FLASH radiotherapy is investigated by varying the assumed dose-rate, fractionation schemes and oxygen concentration in the target. The developed framework describes the reported tumor growth kinetics appropriately, indicating that sparing effects could be present in the tumor but might be too small to be detected with the number of animals used. The TCP predictions show the possibility of substantial loss of treatment efficacy for FLASH radiotherapy depending on several variables, including the fractionation scheme, oxygen level, and DNA repair kinetics. The possible loss of TCP should be seriously considered when assessing the clinical viability of FLASH treatments. |
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| DOI: | doi:10.3390/ijms24065118 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/ijms24065118 |
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| | Volltext: https://www.mdpi.com/1422-0067/24/6/5118 |
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| | DOI: https://doi.org/10.3390/ijms24065118 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | DNA repair |
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| | dose-rate |
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| | FLASH |
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| | ionizing radiation |
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| | modeling |
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| | TCP |
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| | tumor volume |
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| | UNIVERSE |
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| K10plus-PPN: | 1843513234 |
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| Verknüpfungen: | → Zeitschrift |
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Do we preserve Tumor Control Probability (TCP) in FLASH radiotherapy? / Liew, Hans [VerfasserIn]; 7 March 2023 (Online-Ressource)
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