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| |  Online-Ressource |
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| Verfasst von: | Pohl, Moritz [VerfasserIn]  |
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| | Krisam, Johannes [VerfasserIn] |
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| | Kieser, Meinhard [VerfasserIn] |
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| Titel: | Categories, components, and techniques in a modular construction of basket trials for application and further research |
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| Verf.angabe: | Moritz Pohl, Johannes Krisam, Meinhard Kieser |
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| Jahr: | 2021 |
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| Umfang: | 26 S. |
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| Fussnoten: | Gesehen am 12.04.2023 |
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| Titel Quelle: | Enthalten in: Biometrical journal |
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| Ort Quelle: | Berlin : Wiley-VCH, 1977 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 63(2021), 6, Seite 1159-1184 |
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| ISSN Quelle: | 1521-4036 |
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| Abstract: | Basket trials have become a virulent topic in medical and statistical research during the last decade. The core idea of them is to treat patients, who express the same genetic predisposition—either personally or their disease—with the same treatment irrespective of the location of the disease. The location of the disease defines each basket and the pathway of the treatment uses the common genetic predisposition among the baskets. This opens the opportunity to share information among baskets, which can consequently increase the information of the basket-wise response with respect to the investigated treatment. This further allows dynamic decisions regarding futility and efficacy of individual baskets during the ongoing trial. Several statistical designs have been proposed on how a basket trial can be conducted and this has left an unclear situation with many options. The different designs propose different mathematical and statistical techniques, different decision rules, and also different trial purposes. This paper presents a broad overview of existing designs, categorizes them, and elaborates their similarities and differences. A uniform and consistent notation facilitates the first contact, introduction, and understanding of the statistical methodologies and techniques used in basket trials. Finally, this paper presents a modular approach for the construction of basket trials in applied medical science and forms a base for further research of basket trial designs and their techniques. |
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| DOI: | doi:10.1002/bimj.202000314 |
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| URL: | kostenfrei: Volltext: https://doi.org/10.1002/bimj.202000314 |
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| | kostenfrei: Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/bimj.202000314 |
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| | DOI: https://doi.org/10.1002/bimj.202000314 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | basket trial |
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| | Bayes |
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| | frequentist |
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| | overview |
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| | precision medicine |
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| K10plus-PPN: | 1842064851 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Categories, components, and techniques in a modular construction of basket trials for application and further research / Pohl, Moritz [VerfasserIn]; 2021 (Online-Ressource)
69064641
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