Online-Ressource | |
Verfasst von: | Tauziède-Espariat, Arnault [VerfasserIn] |
Uro-Coste, Emmanuelle [VerfasserIn] | |
Sievers, Philipp [VerfasserIn] | |
Nicaise, Yvan [VerfasserIn] | |
Mariet, Cassandra [VerfasserIn] | |
Siegfried, Aurore [VerfasserIn] | |
Pierron, Gaëlle [VerfasserIn] | |
Guillemot, Delphine [VerfasserIn] | |
Benzakoun, Joseph [VerfasserIn] | |
Pallud, Johan [VerfasserIn] | |
Roques, Margaux [VerfasserIn] | |
Bonneville, Fabrice [VerfasserIn] | |
Larrieu-Ciron, Delphine [VerfasserIn] | |
Chaynes, Patrick [VerfasserIn] | |
Saffroy, Raphaël [VerfasserIn] | |
Hamelin, Jocelyne [VerfasserIn] | |
Hasty, Lauren [VerfasserIn] | |
Métais, Alice [VerfasserIn] | |
Chrétien, Fabrice [VerfasserIn] | |
Kool, Marcel [VerfasserIn] | |
Gojo, Johannes [VerfasserIn] | |
Varlet, Pascale [VerfasserIn] | |
Titel: | CNS tumor with EP300 |
Titelzusatz: | :BCOR fusion: discussing its prevalence in adult population |
Verf.angabe: | Arnault Tauziède-Espariat, Emmanuelle Uro-Coste, Philipp Sievers, Yvan Nicaise, Cassandra Mariet, Aurore Siegfried, Gaëlle Pierron, Delphine Guillemot, Joseph Benzakoun, Johan Pallud, Margaux Roques, Fabrice Bonneville, Delphine Larrieu-Ciron, Patrick Chaynes, Raphaël Saffroy, Jocelyne Hamelin, Lauren Hasty, Alice Métais, Fabrice Chrétien, Marcel Kool, Johannes Gojo, Pascale Varlet on behalf of RENOCLIP-LOC |
E-Jahr: | 2023 |
Jahr: | 13 February 2023 |
Umfang: | 7 S. |
Fussnoten: | Gesehen am 05.04.2023 |
Titel Quelle: | Enthalten in: Acta Neuropathologica Communications |
Ort Quelle: | London : Biomed Central, 2013 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 11(2023) vom: Feb., Artikel-ID 26, Seite 1-7 |
ISSN Quelle: | 2051-5960 |
Abstract: | The Central Nervous System (CNS) tumor with BCOR internal tandem duplication (ITD) has recently been added as a novel embryonal histomolecular tumor type to the 2021 World Health Organization (WHO) Classification of CNS Tumors. In addition, other CNS tumors harboring a BCOR/BCORL1 fusion, which are defined by a distinct DNA-methylation profile, have been recently identified in the literature but clinical, radiological and histopathological data remain scarce. Herein, we present two adult cases of CNS tumors with EP300::BCOR fusion. These two cases presented radiological, histopathological, and immunohistochemical homologies with CNS tumors having BCOR ITD in children. To compare these tumors with different BCOR alterations, we performed a literature review with a meta-analysis. CNS tumors with EP300::BCOR fusion seem to be distinct from their BCOR ITD counterparts in terms of age, location, progression-free survival, tumor growth pattern, and immunopositivity for the BCOR protein. CNS tumors from the EP300::BCOR fusion methylation class in adults may be added to the future WHO classification. |
DOI: | doi:10.1186/s40478-023-01523-y |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext: https://doi.org/10.1186/s40478-023-01523-y |
DOI: https://doi.org/10.1186/s40478-023-01523-y | |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Adult |
BCOR | |
EP300 | |
K10plus-PPN: | 1841486442 |
Verknüpfungen: | → Zeitschrift |