Online-Ressource | |
Verfasst von: | Liu, Yibin [VerfasserIn] |
Keib, Anna [VerfasserIn] | |
Neuber, Brigitte [VerfasserIn] | |
Wang, Lei [VerfasserIn] | |
Riemer, Angelika [VerfasserIn] | |
Bonsack, Maria [VerfasserIn] | |
Hückelhoven-Krauss, Angela [VerfasserIn] | |
Schmitt, Anita [VerfasserIn] | |
Müller-Tidow, Carsten [VerfasserIn] | |
Schmitt, Michael [VerfasserIn] | |
Titel: | Definition and characterization of SOX11-derived T cell epitopes towards immunotherapy of glioma |
Verf.angabe: | Yibin Liu, Anna Keib, Brigitte Neuber, Lei Wang, Angelika B. Riemer, Maria Bonsack, Angela Hückelhoven-Krauss, Anita Schmitt, Carsten Müller-Tidow and Michael Schmitt |
E-Jahr: | 2023 |
Jahr: | 18 January 2023 |
Umfang: | 18 S. |
Fussnoten: | Gesehen am 31.03.2023 |
Titel Quelle: | Enthalten in: International journal of molecular sciences |
Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 24(2023), 3, Artikel-ID 1943, Seite 1-18 |
ISSN Quelle: | 1422-0067 |
1661-6596 | |
Abstract: | The transcription factor SOX11 is a tumor-associated antigen with low expression in normal cells, but overexpression in glioblastoma (GBM). So far, conventional surgery, chemotherapy, and radiotherapy have not substantially improved the dismal prognosis of relapsed/refractory GBM patients. Immunotherapy is considered a promising strategy against GBM, but there is a fervent need for better immunotargets in GBM. To this end, we performed an in silico prediction study on SOX11, which primarily yielded ten promising HLA-A*0201-restricted peptides derived from SOX11. We defined a novel peptide FMACSPVAL, which had the highest score according to in silico prediction (6.02 nM by NetMHC-4.0) and showed an exquisite binding affinity to the HLA-A*0201 molecule in the peptide-binding assays. In the IFN-γ ELISPOT assays, FMACSPVAL demonstrated a high efficiency for generating SOX11-specific CD8+ T cells. Nine out of thirty-two healthy donors showed a positive response to SOX11, as assessed by the ELISPOT assays. Therefore, this novel antigen peptide epitope seems to be promising as a target for T cell-based immunotherapy in GBM. The adoptive transfer of in vitro elicited SOX11-specific CD8+ T cells constitutes a potential approach for the treatment of GBM patients. |
DOI: | doi:10.3390/ijms24031943 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt. Volltext: https://doi.org/10.3390/ijms24031943 |
Volltext: https://www.mdpi.com/1422-0067/24/3/1943 | |
DOI: https://doi.org/10.3390/ijms24031943 | |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | glioma |
HLA-A*0201 | |
immunotherapy | |
SOX11 | |
tumor-associated antigen | |
K10plus-PPN: | 1840923490 |
Verknüpfungen: | → Zeitschrift |