| |  Online-Ressource |
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| Verfasst von: | Di Russo, Jacopo [VerfasserIn]  |
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| | Young, Jennifer [VerfasserIn] |
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| | Wegner, Julian W. R. [VerfasserIn] |
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| | Steins, Timmy [VerfasserIn] |
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| | Kessler, Horst [VerfasserIn] |
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| | Spatz, Joachim P. [VerfasserIn] |
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| Titel: | Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity |
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| Verf.angabe: | Jacopo Di Russo, Jennifer L Young, Julian WR Wegner, Timmy Steins, Horst Kessler, Joachim P Spatz |
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| E-Jahr: | 2021 |
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| Jahr: | 23 September 2021 |
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| Umfang: | 18 S. |
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| Fussnoten: | Published: 23 September 2021 ; Gesehen am 09.03.2022 |
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| Titel Quelle: | Enthalten in: eLife |
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| Ort Quelle: | Cambridge : eLife Sciences Publications, 2012 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 10(2021), Artikel-ID 69861, Seite 1-18 |
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| ISSN Quelle: | 2050-084X |
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| Abstract: | Nanometer-scale properties of the extracellular matrix influence many biological processes, including cell motility. While much information is available for single-cell migration, to date, no knowledge exists on how the nanoscale presentation of extracellular matrix receptors influences collective cell migration. In wound healing, basal keratinocytes collectively migrate on a fibronectin-rich provisional basement membrane to re-epithelialize the injured skin. Among other receptors, the fibronectin receptor integrin α5β1 plays a pivotal role in this process. Using a highly specific integrin α5β1 peptidomimetic combined with nanopatterned hydrogels, we show that keratinocyte sheets regulate their migration ability at an optimal integrin α5β1 nanospacing. This efficiency relies on the effective propagation of stresses within the cell monolayer independent of substrate stiffness. For the first time, this work highlights the importance of extracellular matrix receptor nanoscale organization required for efficient tissue regeneration. |
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| DOI: | doi:10.7554/eLife.69861 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.7554/eLife.69861 |
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| | DOI: https://doi.org/10.7554/eLife.69861 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | collective cell migration |
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| | integrin α5β1 |
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| | keratocytes |
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| | wound healing |
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| K10plus-PPN: | 1795146257 |
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| Verknüpfungen: | → Zeitschrift |
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Integrin α5β1 nano-presentation regulates collective keratinocyte migration independent of substrate rigidity / Di Russo, Jacopo [VerfasserIn]; 23 September 2021 (Online-Ressource)
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