Status: Bibliographieeintrag
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| Verfasst von: | Kunzmann, Kevin [VerfasserIn]  |
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| | Kieser, Meinhard [VerfasserIn] |
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| Titel: | Test-compatible confidence intervals for adaptive two-stage single-arm designs with binary endpoint |
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| Verf.angabe: | Kevin Kunzmann, Meinhard Kieser |
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| Jahr: | 2018 |
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| Umfang: | 11 S. |
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| Fussnoten: | First published: 27 October 2017 ; Gesehen am 05.11.2018 |
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| Titel Quelle: | Enthalten in: Biometrical journal |
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| Ort Quelle: | Berlin : Wiley-VCH, 1977 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 60(2018), 1, Seite 196-206 |
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| ISSN Quelle: | 1521-4036 |
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| Abstract: | Inference after two-stage single-arm designs with binary endpoint is challenging due to the nonunique ordering of the sampling space in multistage designs. We illustrate the problem of specifying test-compatible confidence intervals for designs with nonconstant second-stage sample size and present two approaches that guarantee confidence intervals consistent with the test decision. Firstly, we extend the well-known Clopper-Pearson approach of inverting a family of two-sided hypothesis tests from the group-sequential case to designs with fully adaptive sample size. Test compatibility is achieved by using a sample space ordering that is derived from a test-compatible estimator. The resulting confidence intervals tend to be conservative but assure the nominal coverage probability. In order to assess the possibility of further improving these confidence intervals, we pursue a direct optimization approach minimizing the mean width of the confidence intervals. While the latter approach produces more stable coverage probabilities, it is also slightly anti-conservative and yields only negligible improvements in mean width. We conclude that the Clopper-Pearson-type confidence intervals based on a test-compatible estimator are the best choice if the nominal coverage probability is not to be undershot and compatibility of test decision and confidence interval is to be preserved. |
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| DOI: | doi:10.1002/bimj.201700018 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.1002/bimj.201700018 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/bimj.201700018 |
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| | DOI: https://doi.org/10.1002/bimj.201700018 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adaptive designs |
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| | binary endpoint |
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| | confidence interval |
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| | two-stage designs |
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| K10plus-PPN: | 1582568456 |
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| Verknüpfungen: | → Zeitschrift |
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Test-compatible confidence intervals for adaptive two-stage single-arm designs with binary endpoint / Kunzmann, Kevin [VerfasserIn]; 2018 (Online-Ressource)
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