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Verfasst von:Favre‐Bulle, Itia Amandine [VerfasserIn]   i
Titel:Imaging, Manipulation and Optogenetics in Zebrafish
Verf.angabe:by Itia Amandine Favre‐Bulle
Verlagsort:Cham
Verlag:Springer International Publishing
Jahr:2018
Umfang:Online-Ressource (XVIII, 86 p. 49 illus., 23 illus. in color, online resource)
Gesamttitel/Reihe:Springer Theses, Recognizing Outstanding Ph.D. Research
 SpringerLink : Bücher
 Springer eBook Collection
ISBN:978-3-319-96250-4
Abstract:The work described here investigates the advantages and limitations of using laser light for the deep in-vivo illumination and micromanipulation of the neuronal system in zebrafish. To do so, it combines and develops novel optical methods such as optogenetics, light sheet microscopy and optical micromanipulation. It also demonstrates, for the first time, that directional and focused laser beams can successfully be used to target large objects at considerable depth in a living organism to exert purely optical force - in this case on otoliths (ear stones) - and create fictive vestibular stimuli in a stationary animal. The behavioural study and simultaneous imaging of the whole brain reveal the location of the brain cells specific to each ear stone. Elucidating these fundamental neural processes holds substantial value for basic neuroscience researchers, who still have only a vague grasp of how brain circuits mediate perception. As such, it represents highly innovative research that has already led to high-impact publications and is now being intensively pursued
 Introduction -- Light Scattering in Brain Tissue Using Monte Carlo Method -- Scattering in Zebrafish Brain for Optogenetics -- Optical Systems to Decode Brain Activity -- Investigation of Optical Properties of Otoliths with Optical Trapping -- Optical Manipulation of Otoliths in-vivo -- Conclusion
DOI:doi:10.1007/978-3-319-96250-4
URL:Volltext: http://dx.doi.org/10.1007/978-3-319-96250-4
 Resolving-System: https://doi.org/10.1007/978-3-319-96250-4
 DOI: https://doi.org/10.1007/978-3-319-96250-4
Schlagwörter:(s)Bildgebendes Verfahren   i / (s)Nervenzelle   i / (s)Optogenetik   i / (s)Tiermodell   i / (s)Gehirn   i / (s)Zebrabärbling   i / (s)In vivo   i / (s)Teilchenfalle   i / (s)Infrarotlaser   i / (s)Monte-Carlo-Simulation   i
Datenträger:Online-Ressource
Sprache:eng
Reproduktion:Printed edition
 Printed edition
(Gesamttitel):Springer eBook Collection. Physics and Astronomy
Bibliogr. Hinweis:Erscheint auch als : Druck-Ausgabe
K10plus-PPN:1030109079
 
 
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