Titel:	Computational design of ligand binding proteins
Mitwirkende:	Stoddard, Barry L. [HerausgeberIn]
Verf.angabe:	edited by Barry L. Stoddard, Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washigton, USA
Verlagsort:	New York
Verlag:	Humana Press
E-Jahr:	2016
Jahr:	[2016]
Umfang:	xvi, 375 Seiten
Illustrationen:	Illustrationen
Gesamttitel/Reihe:	Methods in molecular biology ; 1414
	Springer protocols
Fussnoten:	Includes bibliographical references and index ; Erscheinungsjahr in Vorlageform:[2016]
Ang. zum Inhalt:	In silico identification and characterization of protein-ligand binding sites / Daniel Barry Roche and Liam James McGuffin
	In silico identification and characterization of protein-ligand binding sites / Daniel Barry Roche and Liam James McGuffin
	Computational modeling of small molecule ligand binding interactions and affinities / Marino Convertino and Nikolay V. Dokholyan
	Binding site prediction of proteins with organic compounds or peptides using GALAXY web servers / Lim Heo [and three others]
	Rosetta and the Design of Ligand Binding Sites / Rocco Moretti [and three others]
	PocketOptimizer and the design of ligand binding sites / Andre C. Stiel, Mehdi Nellen, and Birte Höcker
	Proteus and the design of ligand binding sites / Savvas Polydorides [and five others]
	A structure-based design protocol for optimizing combinatorial protein libraries / Mark W. Lunt and Christopher D. Snow
	Combined and iterative use of computational design and directed evolution for protein-ligand binding design / Meng Wang and Huimin Zhao
	Improving binding affinity and selectivity of computationally designed ligand-binding proteins using experiments / Christine E. Tinberg and Sagar D. Khare
	Computational design of multinuclear metalloproteins using unnatural amino acids / William A. Hansen, Jeremy H. Mills, and Sagar D. Khare
	De novo design of metalloproteins and metalloenzymes in a three-helix bundle / Jefferson S. Plegaria and Vincent L. Pecoraro
	Design of light-controlled protein conformations and functions / Ryan S. Ritterson [and three others]
	Computational introduction of catalytic activity into proteins / Steve J. Bertolani, Dylan Alexander Carlin, and Justin B. Siegel
	Generating high-accuracy peptide-binding data in high throughput with yeast surface display and SORTCERY / Lothar Luther Reich, Sanjib Dutta, and Amy E. Keating
	Design of specific peptide-protein recognition / Fan Zheng and Gevorg Grigoryan
	Computational design of DNA-binding proteins / Summer Thyme and Yifan Song
	Motif-driven design of protein-protein interfaces / Daniel-Adriano Silva, Bruno E. Correia, and Erik Procko
	Computational reprogramming of T cell antigen receptor binding properties / Timothy P. Riley [and four others]
	Computational modeling of T cell receptor complexes / Timothy P. Riley [and four others]
	Computational design of protein linkers / Brian Kuhlman, Tim Jacobs, and Tom Linskey
	Modeling of protein-RNA complex structures using computational docking methods / Bharat Madan [and six others].
	Computational modeling of small molecule ligand binding interactions and affinities / Marino Convertino and Nikolay V. Dokholyan
	Binding site prediction of proteins with organic compounds or peptides using GALAXY web servers / Lim Heo ...[et al.]
	Rosetta and the Design of Ligand Binding Sites / Rocco Moretti ... [et al.]
	PocketOptimizer and the design of ligand binding sites / Andre C. Stiel, Mehdi Nellen, and Birte Höcker
	Proteus and the design of ligand binding sites / Savvas Polydorides ... [et al.]
	Structure-based design protocol for optimizing combinatorial protein libraries / Mark W. Lunt and Christopher D. Snow
	Combined and iterative use of computational design and directed evolution for protein-ligand binding design / Meng Wang and Huimin Zhao
	Improving binding affinity and selectivity of computationally designed ligand-binding proteins using experiments / Christine E. Tinberg and Sagar D. Khare
	Computational design of multinuclear metalloproteins using unnatural amino acids / William A. Hansen, Jeremy H. Mills, and Sagar D. Khare
	De novo design of metalloproteins and metalloenzymes in a three-helix bundle / Jefferson S. Plegaria and Vincent L. Pecoraro
	Design of light-controlled protein conformations and functions / Ryan S. Ritterson ... [et al.]
	Computational Introduction of Catalytic Activity into Proteins / Steve J. Bertolani, Dylan Alexander Carlin, and Justin B. Siegel
	Generating high-accuracy peptide-binding data in high throughput with yeast surface display and SORTCERY / Lothar “Luther” Reich, Sanjib Dutta, and Amy E. Keating
	Design of specific peptide-protein recognition / Fan Zheng and Gevorg Grigoryan
	Computational design of DNA-binding proteins / Summer Thyme and Yifan Song
	Motif-driven design of protein-protein interfaces / Daniel-Adriano Silva, Bruno E. Correia, and Erik Procko
	Computational reprogramming of T cell antigen receptor binding properties / Timothy P. Riley ... [et al.]
	Computational modeling of T cell receptor complexes / Timothy P. Riley ... [et al.]
	Computational design of protein linkers / Brian Kuhlman, Tim Jacobs, and Tom Linskey
	Modeling of protein-RNA complex structures using computational docking methods / Bharat Madan ... [et al.].
ISBN:	978-1-4939-8080-2
	978-1-4939-3567-3
	978-1-4939-3567-3
Abstract:	This volume provides a collection of protocols and approaches for the creation of novel ligand binding proteins, compiled and described by many of today's leaders in the field of protein engineering. Chapters focus on modeling protein ligand binding sites, accurate modeling of protein-ligand conformational sampling, scoring of individual docked solutions, structure-based design program such as ROSETTA, protein engineering, and additional methodological approaches. Examples of applications include the design of metal-binding proteins and light-induced ligand binding proteins, the creation of binding proteins that also display catalytic activity, and the binding of larger peptide, protein, DNA and RNA ligands. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls
URL:	Cover: https://swbplus.bsz-bw.de/bsz475386736cov.jpg
Schlagwörter:	(s)Protein-Protein-Wechselwirkung    / (s)Ligand    / (s)Mathematisches Modell
Sprache:	eng
Bibliogr. Hinweis:	Erscheint auch als : Online-Ausgabe: Computational Design of Ligand Binding Proteins. - New York, NY : Humana Press, 2016. - Online-Ressource (XVI, 375 p. 94 illus., 76 illus. in color, online resource)
RVK-Notation:	WC 7700
K10plus-PPN:	851199151
Verknüpfungen:	→ Übergeordnete Aufnahme