| |  Online-Ressource |
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| Verfasst von: | Haley, John D.  |
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| Titel: | EGFR Signaling Networks in Cancer Therapy |
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| Mitwirkende: | Gullick, William John |
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| Verf.angabe: | edited by John D. Haley, William John Gullick |
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| Verlagsort: | Totowa, NJ |
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| Verlag: | Humana Press |
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| Jahr: | 2008 |
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| Umfang: | Online-Ressource (XI, 393p, digital) |
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| Gesamttitel/Reihe: | Cancer Drug Discovery and Development |
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| | SpringerLink : Bücher |
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| Fussnoten: | Includes bibliographical references and index |
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| ISBN: | 978-1-59745-356-1 |
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| Abstract: | The epidermal growth factor (EGF) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGFR therapies. Edited by John Haley and William J. Gullick, EGFR Signaling Networks in Cancer Therapy, is separated into two sections. The first of which probes the molecular pathways and the intersection of signaling networks which are frequently deregulated in human cancers, with a view to describing EGF receptor in a tumor tissue specific context. Meanwhile, the second section illustrates the many ways in which EGF receptor contribute to abnormal survival and migration signaling in cancer cells and to epithelial to mesenchymal transition and metastasis. The book also describes the mitogenic, survival, adhesive and migratory pathways within a framework of interacting subsystems that contribute to the activity and physiological regulation of the receptor in normal and neoplastic tissues. Even though there is still much to learn, this volume explores this fascinating system with compelling information. |
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| DOI: | doi:10.1007/978-1-59745-356-1 |
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| URL: | Volltext: https://doi.org/10.1007/978-1-59745-356-1 |
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| | Volltext: http://dx.doi.org/10.1007/978-1-59745-356-1 |
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| | Cover: https://swbplus.bsz-bw.de/bsz288580702cov.jpg |
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| | Inhaltsverzeichnis: https://swbplus.bsz-bw.de/bsz285717022inh.htm |
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| | DOI: https://doi.org/10.1007/978-1-59745-356-1 |
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| Schlagwörter: | (s)Epidermaler Wachstumsfaktor-Rezeptor / (s)Krebsbekämpfung |
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| | (s)Epidermaler Wachstumsfaktor-Rezeptor / (s)Cytostatikum |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Reproduktion: | Buchausg. u.d.T.: EGFR signaling networks in cancer therapy. - Totowa, N.J.: Humana Press, 2008. - XI, 393 |
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| | Druckausg.: EGFR signaling networks in cancer therapy. - New York, NY: Humana Press, 2008. - XI, 393 S |
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| RVK-Notation: | XH 2550 |
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| Sach-SW: | Radiation-sensitizing agents |
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| | Drug resistance in cancer cells |
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| | Antineoplastic agents |
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| K10plus-PPN: | 1647727367 |
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| Lokale URL UB: |  Zum Volltext |
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| | Bibliothek der Medizinischen Fakultät Mannheim der Universität Heidelberg |
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| |  Bestellen/Vormerken für Benutzer des Klinikums Mannheim
Eigene Kennung erforderlich |
| Bibliothek/Idn: | UW / m3324553121 |
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| Lokale URL Inst.: | Zum Volltext |
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EGFR Signaling Networks in Cancer Therapy / Haley, John D.; 2008 (Online-Ressource)
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