| |  Online-Ressource |
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| Verfasst von: | Mierau, Rudolf [VerfasserIn]  |
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| | Moinzadeh, Pia [VerfasserIn] |
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| | Riemekasten, Gabriela [VerfasserIn] |
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| | Melchers, Inga [VerfasserIn] |
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| | Meurer, Michael [VerfasserIn] |
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| | Reichenberger, Frank [VerfasserIn] |
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| | Buslau, Michael [VerfasserIn] |
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| | Worm, Margitta [VerfasserIn] |
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| | Blank, Norbert [VerfasserIn] |
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| | Hein, Rüdiger [VerfasserIn] |
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| | Müller-Ladner, Ulf [VerfasserIn] |
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| | Kuhn, Annegret [VerfasserIn] |
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| | Sunderkötter, Cord [VerfasserIn] |
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| | Juche, Aaron [VerfasserIn] |
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| | Pfeiffer, Christiane [VerfasserIn] |
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| | Fiehn, Christoph [VerfasserIn] |
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| | Sticherling, Michael [VerfasserIn] |
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| | Lehmann, Percy [VerfasserIn] |
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| | Stadler, Rudolf [VerfasserIn] |
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| | Schulze-Lohoff, Eckhard [VerfasserIn] |
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| | Seitz, Cornelia [VerfasserIn] |
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| | Foeldvari, Ivan [VerfasserIn] |
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| | Krieg, Thomas [VerfasserIn] |
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| | Genth, Ekkehard [VerfasserIn] |
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| | Hunzelmann, Nicolas [VerfasserIn] |
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| Titel: | Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma |
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| Titelzusatz: | correlation with characteristic clinical features |
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| Verf.angabe: | Rudolf Mierau, Pia Moinzadeh, Gabriela Riemekasten, Inga Melchers, Michael Meurer, Frank Reichenberger, Michael Buslau, Margitta Worm, Norbert Blank, Rüdiger Hein, Ulf Müller-Ladner, Annegret Kuhn, Cord Sunderkötter, Aaron Juche, Christiane Pfeiffer, Christoph Fiehn, Michael Sticherling, Percy Lehmann, Rudolf Stadler, Eckhard Schulze-Lohoff, Cornelia Seitz, Ivan Foeldvari, Thomas Krieg, Ekkehard Genth and Nicolas Hunzelmann |
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| E-Jahr: | 2011 |
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| Jahr: | 21 October 2011 |
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| Umfang: | 14 S. |
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| Fussnoten: | Gesehen am 19.08.2022 |
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| Titel Quelle: | Enthalten in: Arthritis Research & Therapy |
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| Ort Quelle: | London : BioMed Central, 1999 |
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| Jahr Quelle: | 2011 |
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| Band/Heft Quelle: | 13(2011), 5, Artikel-ID R172, Seite 1-14 |
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| ISSN Quelle: | 1465-9913 |
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| | 1478-6362 |
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| Abstract: | Introduction: In the present study, we analysed in detail nuclear autoantibodies and their associations in systemic sclerosis (SSc) patients included in the German Network for Systemic Scleroderma Registry. Methods: Sera of 863 patients were analysed according to a standardised protocol including immunofluorescence, immunoprecipitation, line immunoassay and immunodiffusion. Results: Antinuclear antibodies (ANA) were detected in 94.2% of patients. In 81.6%, at least one of the autoantibodies highly associated with SSc or with overlap syndromes with scleroderma features was detected, that is, anti-centromere (35.9%) or anti-topoisomerase I (30.1%), followed in markedly lower frequency by antibodies to PM-Scl (4.9%), U1-ribonucleoprotein (U1-RNP) (4.8%), RNA polymerases (RNAPs) (3.8%), fibrillarin (1.4%), Ku (1.2%), aminoacyl-transfer RNA synthetases (0.5%), To (0.2%) and U11-RNP (0.1%). We found that the simultaneous presence of SSc-associated autoantibodies was rare (1.6%). Furthermore, additional autoantibodies were detected in 55.4% of the patients with SSc, of which anti-Ro/anti-La, anti-mitochondrial and anti-p25/p23 antibodies were most frequent. The coexistence of SSc-associated and other autoantibodies was common (43% of patients). SSc-associated autoantibodies disclosed characteristic associations with clinical features of patients, some of which were previously not acknowledged. Conclusions: This study shows that five autoantigens (that is, centromere, topoisomerase I, PM-Scl, U1-RNP and RNAP) detected more than 95% of the known SSc-associated antibody responses in ANA-positive SSc patients and characterise around 79% of all SSc patients in a central European cohort. These data confirm and extend previous data underlining the central role of the determination of ANAs in defining the diagnosis, subset allocation and prognosis of SSc patients. |
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| DOI: | doi:10.1186/ar3495 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1186/ar3495 |
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| | DOI: https://doi.org/10.1186/ar3495 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | antinuclear antibodies |
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| | autoantibodies |
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| | scleroderma |
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| | systemic sclerosis |
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| K10plus-PPN: | 1814730079 |
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| Verknüpfungen: | → Zeitschrift |
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Frequency of disease-associated and other nuclear autoantibodies in patients of the German network for systemic scleroderma / Mierau, Rudolf [VerfasserIn]; 21 October 2011 (Online-Ressource)
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