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Status: 
| Verfasst von: | Sinha, Subarna |
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| | Knapp, Merrill |
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| | Pywtorak, John |
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| | McCain, Greg |
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| | Wingerden, Kenneth |
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| | VanDervoort, Colin |
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| | Gondek, J. Mark |
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| | Madrid, Peter |
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| | Parman, Toufan |
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| | Gerrard, Stephen |
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| | Long, Jill E |
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| | Blithe, Diana L |
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| | Moss, Stuart |
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| | Lee, Min S |
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| Titel: | Contraceptive and Infertility Target DataBase: a contraceptive drug development tool for targeting and analysis of human reproductive specific tissues |
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| Verlagsort: | United States |
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| Verlag: | Society for the Study of Reproduction |
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| | Oxford University Press |
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| Jahr: | 2021 |
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| Umfang: | 9 S. |
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| Fussnoten: | Co-authored this article while at SRI International. ; Co-authored this article while at the Bill and Melinda Gates Foundation. ; ObjectType-Article-1 ; ObjectType-Feature-2 ; SourceType-Scholarly Journals-1 ; content type line 23 |
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| Inhalt: | The long and challenging drug development process begins with discovery biology for the selection of an appropriate target for a specific indication. Target is a broad term that can be applied to a range of biological entities such as proteins, genes, and ribonucleic acids (RNAs). Although there are numerous databases available for mining biological entities, publicly available searchable, downloadable databases to aid in target selection for a specific disease or indication (e.g., developing contraceptives and infertility treatments) are limited. We report the development of the Contraceptive and Infertility Target DataBase (https://www.citdbase.org), which provides investigators an interface to mine existing transcriptomic and proteomic resources to identify high-quality contraceptive/infertility targets. The development of similar databases is applicable to the identification of targets for other diseases and conditions. Summary sentence Contraceptive and Infertility Target DataBase is a searchable and downloadable database open to the public for the identification of contraceptive/infertility transcriptomic and proteomic targets. Graphical Abstract |
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| ISSN: | 0006-3363 |
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| Titel Quelle: | Biology of reproduction |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 105, 6, S. 1366-1374 |
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| DOI: | doi:10.1093/biolre/ioab172 |
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| URL: | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttp%2Fwww.bioone.org%2Fdoi%2Fabs%2F10.1093%2Fbiolre%2Fioab172 |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F34514504 |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fsearch.proquest.com%2Fdocview%2F2572214741 |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fpubmed.ncbi.nlm.nih.gov%2FPMC8831241 |
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| | DOI: https://doi.org/10.1093/biolre/ioab172 |
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| Sprache: | English |
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| Sach-SW: | contraceptive |
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| | Contraceptive Agents - pharmacology |
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| | Databases as Topic - statistics & numerical data |
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| | Drug Development - instrumentation |
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| | Humans |
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| | Infertility |
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| | Mineral industry |
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| | Mining industry |
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| | Oral contraceptives |
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| | Proteome |
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| | proteomics targets |
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| | Reproduction - drug effects |
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| | RESEARCH ARTICLE |
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| | Transcriptome |
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| | transcriptomic targets |
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| Verknüpfungen: | → Sammelwerk |
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