| Verfasst von: | Chia, Stephen K. |
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| | Speers, Caroline H. |
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| | D'yachkova, Yulia |
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| | Kang, Anna |
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| | Malfair‐Taylor, Suzanne |
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| | Barnett, Jeff |
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| | Coldman, Andy |
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| | Gelmon, Karen A. |
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| | O'Reilly, Susan E. |
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| | Olivotto, Ivo A. |
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| Titel: | The impact of new chemotherapeutic and hormone agents on survival in a population‐based cohort of women with metastatic breast cancer |
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| Verlagsort: | Hoboken |
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| Verlag: | Wiley Subscription Services, Inc., A Wiley Company |
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| | Wiley-Liss |
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| Jahr: | 2007 |
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| Umfang: | 7 S. |
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| Fussnoten: | Fax: (604) 877‐0585 ; ObjectType-Article-1 ; ObjectType-Feature-2 ; Presented in part at the 39th Annual Meeting of the American Society of Clinical Oncology, Chicago, Illinois, May 31 to June 3, 2003. ; SourceType-Scholarly Journals-1 ; content type line 23 |
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| Inhalt: | BACKGROUND.
Over the past decade, a number of new therapeutic agents have become available in the treatment of metastatic breast cancer (MBC). This study characterized the use and assessed the impact on survival of population‐based access to new agents for the treatment of MBC.
METHODS.
The dates of release in British Columbia of 7 new systemic agents for MBC during the 1990s were used to construct 4 time cohorts. All patients with a first diagnosis of distant metastases in each of the time cohorts were identified and characterized, and their survival was compared. Cox proportional regression modeling was used to assess for predictors of survival.
RESULTS.
In total, 2150 patients with a first distant metastases diagnosed during 1 of the 4 cohort intervals were identified. Baseline characteristics between cohorts were similar, except a greater proportion of the later cohorts received adjuvant chemotherapy (P < .001), had positive estrogen receptor status (P = .01), and had a longer median time from initial diagnosis to MBC (P < .001). Survival in Cohort 1 (1991–1992) and Cohort 2 (1994–1995; median, 438 days and 450 days, respectively) was similar. Survival was longer in Cohort 3 (1997–1998; median, 564 days; P = .002) and improved further in Cohort 4 (1999–2001; median, 667 days; P = .05). In multivariate analysis, the later cohorts were associated independently with improved survival (P = .01 and P < .001, respectively).
CONCLUSIONS.
Population‐based access to new therapeutic agents for MBC appeared to be associated with improved survival. To the authors' knowledge, this is the first study to date that demonstrates, from a population‐based perspective, improving survival over the past decade for women with MBC. Cancer 2007. © 2007 American Cancer Society.
The results from this population‐based study demonstrated improved survival over time in a large cohort of women with metastatic breast cancer (MBC). Population‐based access to new therapeutic agents for MBC appeared to be associated with this improved survival. |
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| ISSN: | 0008-543X |
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| Titel Quelle: | Cancer |
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| Jahr Quelle: | 2007 |
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| Band/Heft Quelle: | 110, 5, S. 973-979 |
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| DOI: | doi:10.1002/cncr.22867 |
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| URL: | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fonlinelibrary.wiley.com%2Fdoi%2Fabs%2F10.1002%2Fcncr.2286 ... |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F17647245 |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fsearch.proquest.com%2Fdocview%2F68292442 |
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| | DOI: https://doi.org/10.1002/cncr.22867 |
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| Sprache: | English |
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| Sach-SW: | Adult |
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| | Aged |
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| | Antineoplastic Agents, Hormonal - therapeutic use |
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| | Biological and medical sciences |
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| | Breast Neoplasms - drug therapy |
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| | Breast Neoplasms - epidemiology |
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| | Breast Neoplasms - pathology |
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| | British Columbia - epidemiology |
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| | chemotherapy |
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| | Cohort Studies |
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| | Databases as Topic - statistics & numerical data |
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| | Drug Therapy - methods |
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| | Drug Therapy - statistics & numerical data |
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| | Female |
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| | Gynecology. Andrology. Obstetrics |
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| | hormone therapy |
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| | Humans |
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| | Kaplan-Meier Estimate |
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| | Mammary gland diseases |
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| | Medical sciences |
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| | metastatic breast cancer |
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| | Middle Aged |
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| | Multivariate Analysis |
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| | Neoplasm Metastasis |
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| | Prognosis |
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| | Proportional Hazards Models |
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| | survival |
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| | Treatment Outcome |
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| | Tumors |
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| Verknüpfungen: | → Sammelwerk |
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