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| Verfasst von: | Ratliff, Miriam [VerfasserIn]  |
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| | Karimian-Jazi, Kianush [VerfasserIn] |
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| | Hoffmann, Dirk C. [VerfasserIn] |
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| | Rauschenbach, Laurèl [VerfasserIn] |
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| | Simon, Matthias [VerfasserIn] |
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| | Hai, Ling [VerfasserIn] |
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| | Mandelbaum, Hannah [VerfasserIn] |
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| | Schubert, Marc Cicero [VerfasserIn] |
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| | Keßler, Tobias [VerfasserIn] |
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| | Uhlig, Stefanie [VerfasserIn] |
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| | Domínguez Azorín, Daniel [VerfasserIn] |
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| | Jung, Erik [VerfasserIn] |
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| | Osswald, Matthias [VerfasserIn] |
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| | Solecki, Gergely [VerfasserIn] |
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| | Maros, Máté E. [VerfasserIn] |
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| | Venkataramani, Varun [VerfasserIn] |
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| | Glas, Martin [VerfasserIn] |
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| | Etminan, Nima [VerfasserIn] |
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| | Scheffler, Björn [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Winkler, Frank [VerfasserIn] |
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| Titel: | Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression |
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| Titelzusatz: | journal article |
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| Verf.angabe: | Miriam Ratliff, Kianush Karimian-Jazi, Dirk C. Hoffmann, Laurèl Rauschenbach, Matthias Simon, Ling Hai, Henriette Mandelbaum, Marc C. Schubert, Tobias Kessler, Stefanie Uhlig, Daniel Dominguez Azorin, Erik Jung, Matthias Osswald, Gergely Solecki, Máté E. Maros, Varun Venkataramani, Martin Glas, Nima Etminan, Björn Scheffler, Wolfgang Wick and, Frank Winkler |
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| E-Jahr: | 2023 |
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| Jahr: | December 2023 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Online veröffentlicht: 19. Juni 2023 ; Gesehen am 26.02.2024 |
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| Titel Quelle: | Enthalten in: Neuro-Oncology |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1999 |
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| Jahr Quelle: | 2023 |
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| Band/Heft Quelle: | 25(2023), 12 vom: Dez., Seite 2150-2162 |
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| ISSN Quelle: | 1523-5866 |
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| Abstract: | Glioblastomas are characterized by aggressive and infiltrative growth, and by striking heterogeneity. The aim of this study was to investigate whether tumor cell proliferation and invasion are interrelated, or rather distinct features of different cell populations.Tumor cell invasion and proliferation were longitudinally determined in real-time using 3D in vivo 2-photon laser scanning microscopy over weeks. Glioblastoma cells expressed fluorescent markers that permitted the identification of their mitotic history or their cycling versus non-cycling cell state.Live reporter systems were established that allowed us to dynamically determine the invasive behavior, and previous or actual proliferation of distinct glioblastoma cells, in different tumor regions and disease stages over time. Particularly invasive tumor cells that migrated far away from the main tumor mass, when followed over weeks, had a history of marked proliferation and maintained their proliferative capacity during brain colonization. Infiltrating cells showed fewer connections to the multicellular tumor cell network, a typical feature of gliomas. Once tumor cells colonized a new brain region, their phenotype progressively transitioned into tumor microtube-rich, interconnected, slower-cycling glioblastoma cells. Analysis of resected human glioblastomas confirmed a higher proliferative potential of tumor cells from the invasion zone.The detection of glioblastoma cells that harbor both particularly high proliferative and invasive capabilities during brain tumor progression provides valuable insights into the interrelatedness of proliferation and migration—2 central traits of malignancy in glioma. This contributes to our understanding of how the brain is efficiently colonized in this disease. |
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| DOI: | doi:10.1093/neuonc/noad109 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/neuonc/noad109 |
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| | Volltext: https://academic.oup.com/neuro-oncology/article/25/12/2150/7202146 |
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| | DOI: https://doi.org/10.1093/neuonc/noad109 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 1881586170 |
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| Verknüpfungen: | → Zeitschrift |
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Individual glioblastoma cells harbor both proliferative and invasive capabilities during tumor progression / Ratliff, Miriam [VerfasserIn]; December 2023 (Online-Ressource)
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