| Online-Ressource |
Verfasst von: | Cheng, Chao [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Hong, Wei [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Li, Yafang [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Xiao, Xiangjun [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| McKay, James [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Han, Younghun [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Byun, Jinyoung [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Peng, Bo [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Albanes, Demetrios [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Lam, Stephen [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Tardon, Adonina [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Chen, Chu [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Bojesen, Stig E. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Landi, Maria T. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Johansson, Mattias [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Risch, Angela [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Bickeböller, Heike [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Wichmann, H-Erich [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Christiani, David C. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Rennert, Gad [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Arnold, Susanne [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Goodman, Gary [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Field, John K. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Davies, Michael P. A. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Shete, Sanjay S. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Le Marchand, Loic [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Liu, Geoffrey [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Hung, Rayjean J. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Andrew, Angeline S. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Kiemeney, Lambertus A. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Zhu, Meng [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Shen, Hongbing [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Zienolddiny, Shan [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Grankvist, Kjell [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Johansson, Mikael [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Cox, Angela [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Hong, Yun-Chul [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Yuan, Jian-Min [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Lazarus, Philip [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Schabath, Matthew B. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Aldrich, Melinda C. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Brennan, Paul [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Li, Yong [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Gorlova, Olga [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Gorlov, Ivan [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
| Amos, Christopher I. [VerfasserIn] ![i](/https/katalog.ub.uni-heidelberg.de/opacicon/information2.png) |
Titel: | Mosaic chromosomal alterations are associated with increased lung cancer risk |
Titelzusatz: | insight from the INTEGRAL-ILCCO cohort analysis |
Verf.angabe: | Chao Cheng, Wei Hong, Yafang Li, Xiangjun Xiao, James McKay, Younghun Han, Jinyoung Byun, Bo Peng, Demetrios Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Stig E. Bojesen, Maria T. Landi, Mattias Johansson, Angela Risch, Heike Bickeböller, H-Erich Wichmann, David C. Christiani, Gad Rennert, Susanne Arnold, Gary Goodman, John K. Field, Michael P. A. Davies, Sanjay S. Shete, Loic Le Marchand, Geoffrey Liu, Rayjean J. Hung, Angeline S. Andrew, Lambertus A. Kiemeney, Meng Zhu, Hongbing Shen, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Angela Cox, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Paul Brennan, Yong Li, Olga Gorlova, Ivan Gorlov, Christopher I. Amos |
E-Jahr: | 2023 |
Jahr: | August 2023 |
Umfang: | 14 S. |
Fussnoten: | Online verfügbar: 5. Mai 2023, Artikelversion: 19. Juli 2023 ; Gesehen am 13.10.2023 |
Titel Quelle: | Enthalten in: Journal of thoracic oncology |
Ort Quelle: | Amsterdam : Elsevier, 2006 |
Jahr Quelle: | 2023 |
Band/Heft Quelle: | 18(2023), 8 vom: Aug., Seite 1003-1016 |
ISSN Quelle: | 1556-1380 |
Abstract: | Introduction - Mosaic chromosomal alterations (mCAs) detected in white blood cells represent a type of clonal hematopoiesis (CH) that is understudied compared with CH-related somatic mutations. A few recent studies indicated their potential link with nonhematological cancers, especially lung cancer. - Methods - In this study, we investigated the association between mCAs and lung cancer using the high-density genotyping data from the OncoArray study of INTEGRAL-ILCCO, the largest single genetic study of lung cancer with 18,221 lung cancer cases and 14,825 cancer-free controls. - Results - We identified a comprehensive list of autosomal mCAs, ChrX mCAs, and mosaic ChrY (mChrY) losses from these samples. Autosomal mCAs were detected in 4.3% of subjects, in addition to ChrX mCAs in 3.6% of females and mChrY losses in 9.6% of males. Multivariable logistic regression analysis indicated that the presence of autosomal mCAs in white blood cells was associated with an increased lung cancer risk after adjusting for key confounding factors, including age, sex, smoking status, and race. This association was mainly driven by a specific type of mCAs: copy-neutral loss of heterozygosity on autosomal chromosomes. The association between autosome copy-neutral loss of heterozygosity and increased risk of lung cancer was further confirmed in two major histologic subtypes, lung adenocarcinoma and squamous cell carcinoma. In addition, we observed a significant increase of ChrX mCAs and mChrY losses in smokers compared with nonsmokers and racial differences in certain types of mCA events. - Conclusions - Our study established a link between mCAs in white blood cells and increased risk of lung cancer. |
DOI: | doi:10.1016/j.jtho.2023.05.001 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jtho.2023.05.001 |
| Volltext: https://www.sciencedirect.com/science/article/pii/S1556086423005270 |
| DOI: https://doi.org/10.1016/j.jtho.2023.05.001 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Clonal hematopoiesis |
| Loss of heterozygosity |
| Lung cancer risk |
| Mosaic chromosomal alterations |
K10plus-PPN: | 1863806156 |
Verknüpfungen: | → Zeitschrift |
Mosaic chromosomal alterations are associated with increased lung cancer risk / Cheng, Chao [VerfasserIn]; August 2023 (Online-Ressource)