| |  Online-Ressource |
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| Verfasst von: | Busch, Elena [VerfasserIn]  |
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| | Ahadova, Aysel [VerfasserIn] |
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| | Jäger, Dirk [VerfasserIn] |
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| | Knebel Doeberitz, Magnus von [VerfasserIn] |
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| | Haag, Georg Martin [VerfasserIn] |
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| | Kloor, Matthias [VerfasserIn] |
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| Titel: | Beta-2-microglobulin mutations are linked to a distinct metastatic pattern and a favorable outcome in microsatellite-unstable stage IV gastrointestinal cancers |
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| Verf.angabe: | Elena Busch, Aysel Ahadova, Kosima Kosmalla, Lena Bohaumilitzky, Pauline L. Pfuderer, Alexej Ballhausen, Johannes Witt, Jan-Niklas Wittemann, Hendrik Bläker, Elke Holinski-Feder, Dirk Jäger, Magnus von Knebel Doeberitz, Georg Martin Haag and Matthias Kloor |
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| E-Jahr: | 2021 |
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| Jahr: | 08 June 2021 |
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| Umfang: | 7 S. |
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| Teil: | volume:11 |
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| | year:2021 |
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| | day:8 |
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| | month:06 |
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| | elocationid:669774 |
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| | extent:7 |
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| Fussnoten: | Gesehen am 06.07.2021 |
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| Titel Quelle: | Enthalten in: Frontiers in oncology |
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| Ort Quelle: | Lausanne : Frontiers Media, 2011 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 11(2021) vom: 8. Juni, Artikel-ID 669774 |
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| ISSN Quelle: | 2234-943X |
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| Abstract: | Immune checkpoint blockade (ICB) shows remarkable clinical effects in patients with metastatic microsatellite-unstable (MSI) cancer. However, markers identifying potential non-responders are missing. We examined the prevalence of Beta-2-microglobulin (B2M) mutations, a common immune evasion mechanism, in stage IV MSI gastrointestinal cancer and its influence on metastatic pattern and patients’ survival under ICB. Twenty-five patients with metastatic, MSI gastrointestinal adenocarcinoma were included. Eighteen patients underwent ICB with pembrolizumab and one patient with nivolumab/ipilimumab. Sequencing was performed to determine B2M mutation status. B2M mutations and loss of B2M expression were detected in 6 out of 25 stage IV MSI cancers. B2M mutations were strongly associated with exclusively peritoneal metastasis (p=0.0312). However, no significant differences in therapy response (25% vs. 46.6%, p>0.99) and survival (median PFS: 19.5 vs 33.0 months, p=0.74; median OS 39 months vs. not reached, p>0.99) were observed between B2M-mutant and B2M-wild type tumor patients. Among metastatic MSI GI cancers, B2M-mutant tumors represent a biologically distinct disease with distinct metastatic patterns. To assess ICB response in B2M-mutant MSI cancer patients, future studies need to account for the fact that baseline survival of patients with B2M-mutant MSI cancer may be longer than of patients with B2M-wild type MSI cancer. |
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| DOI: | doi:10.3389/fonc.2021.669774 |
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| URL: | Kostenfrei: Volltext ; Verlag: https://doi.org/10.3389/fonc.2021.669774 |
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| | Kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fonc.2021.669774/full |
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| | DOI: https://doi.org/10.3389/fonc.2021.669774 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | B2M mutation |
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| | Immune checkpoint blockade |
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| | Metastatic pattern |
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| | MSI cancer |
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| | prognosis |
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| K10plus-PPN: | 1761982885 |
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| Verknüpfungen: | → Zeitschrift |
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| Lokale URL UB: |  Zum Volltext |
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Beta-2-microglobulin mutations are linked to a distinct metastatic pattern and a favorable outcome in microsatellite-unstable stage IV gastrointestinal cancers / Busch, Elena [VerfasserIn]; 08 June 2021 (Online-Ressource)
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