| |  Online-Ressource |
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| Verfasst von: | Bénard, Alan [VerfasserIn]  |
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| | Jacobsen, Anne [VerfasserIn] |
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| | Brunner, Maximilian [VerfasserIn] |
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| | Krautz, Christian [VerfasserIn] |
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| | Klösch, Bettina [VerfasserIn] |
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| | Swierzy, Izabela [VerfasserIn] |
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| | Naschberger, Elisabeth [VerfasserIn] |
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| | Podolska, Malgorzata J. [VerfasserIn] |
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| | Kouhestani, Dina [VerfasserIn] |
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| | David, Paul [VerfasserIn] |
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| | Birkholz, Torsten [VerfasserIn] |
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| | Castellanos, Ixchel [VerfasserIn] |
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| | Trufa, Denis [VerfasserIn] |
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| | Sirbu, Horia [VerfasserIn] |
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| | Vetter, Marcel [VerfasserIn] |
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| | Kremer, Andreas E. [VerfasserIn] |
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| | Hildner, Kai [VerfasserIn] |
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| | Hecker, Andreas [VerfasserIn] |
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| | Edinger, Fabian [VerfasserIn] |
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| | Tenbusch, Matthias [VerfasserIn] |
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| | Mühl-Zürbes, Petra [VerfasserIn] |
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| | Steinkasserer, Alexander [VerfasserIn] |
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| | Richter, Enrico [VerfasserIn] |
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| | Streeck, Hendrik [VerfasserIn] |
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| | Berger, Marc M. [VerfasserIn] |
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| | Brenner, Thorsten [VerfasserIn] |
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| | Weigand, Markus A. [VerfasserIn] |
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| | Swirski, Filip K. [VerfasserIn] |
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| | Schett, Georg [VerfasserIn] |
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| | Grützmann, Robert [VerfasserIn] |
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| | Weber, Georg Ferdinand [VerfasserIn] |
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| Titel: | Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections |
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| Verf.angabe: | Alan Bénard, Anne Jacobsen, Maximilian Brunner, Christian Krautz, Bettina Klösch, Izabela Swierzy, Elisabeth Naschberger, Malgorzata J. Podolska, Dina Kouhestani, Paul David, Torsten Birkholz, Ixchel Castellanos, Denis Trufa, Horia Sirbu, Marcel Vetter, Andreas E. Kremer, Kai Hildner, Andreas Hecker, Fabian Edinger, Matthias Tenbusch, Petra Mühl-Zürbes, Alexander Steinkasserer, Enrico Richter, Hendrik Streeck, Marc M. Berger, Thorsten Brenner, Markus A. Weigand, Filip K. Swirski, Georg Schett, Robert Grützmann & Georg F. Weber |
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| E-Jahr: | 2021 |
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| Jahr: | 18 February 2021 |
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| Umfang: | 8 S. |
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| Teil: | volume:12 |
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| | year:2021 |
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| | elocationid:1112 |
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| | pages:1-8 |
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| | extent:8 |
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| Fussnoten: | Gesehen am 02.09.2021 |
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| Titel Quelle: | Enthalten in: Nature Communications |
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| Ort Quelle: | [London] : Nature Publishing Group UK, 2010 |
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| Jahr Quelle: | 2021 |
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| Band/Heft Quelle: | 12(2021), Artikel-ID 1112, Seite 1-8 |
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| ISSN Quelle: | 2041-1723 |
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| Abstract: | Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a worldwide health threat. In a prospective multicentric study, we identify IL-3 as an independent prognostic marker for the outcome during SARS-CoV-2 infections. Specifically, low plasma IL-3 levels is associated with increased severity, viral load, and mortality during SARS-CoV-2 infections. Patients with severe COVID-19 exhibit also reduced circulating plasmacytoid dendritic cells (pDCs) and low plasma IFNα and IFNλ levels when compared to non-severe COVID-19 patients. In a mouse model of pulmonary HSV-1 infection, treatment with recombinant IL-3 reduces viral load and mortality. Mechanistically, IL-3 increases innate antiviral immunity by promoting the recruitment of circulating pDCs into the airways by stimulating CXCL12 secretion from pulmonary CD123+ epithelial cells, both, in mice and in COVID-19 negative patients exhibiting pulmonary diseases. This study identifies IL-3 as a predictive disease marker for SARS-CoV-2 infections and as a potential therapeutic target for pulmunory viral infections. |
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| DOI: | doi:10.1038/s41467-021-21310-4 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1038/s41467-021-21310-4 |
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| | Volltext: https://www.nature.com/articles/s41467-021-21310-4 |
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| | DOI: https://doi.org/10.1038/s41467-021-21310-4 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| K10plus-PPN: | 175353416X |
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| Verknüpfungen: | → Zeitschrift |
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Interleukin-3 is a predictive marker for severity and outcome during SARS-CoV-2 infections / Bénard, Alan [VerfasserIn]; 18 February 2021 (Online-Ressource)
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