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Status: 
| Verfasst von: | Keown, Christopher Lee |
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| | Shih, Patricia |
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| | Nair, Aarti |
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| | Peterson, Nick |
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| | Mulvey, Mark Edward |
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| | Müller, Ralph-Axel |
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| Titel: | Local Functional Overconnectivity in Posterior Brain Regions Is Associated with Symptom Severity in Autism Spectrum Disorders |
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| Verlagsort: | United States |
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| Verlag: | Elsevier Inc |
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| | Elsevier |
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| Jahr: | 2013 |
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| Fussnoten: | ObjectType-Article-1 ; ObjectType-Feature-2 ; SourceType-Scholarly Journals-1 ; content type line 23 |
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| Inhalt: | Although growing evidence indicates atypical long-distance connectivity in autism spectrum disorder (ASD), much less is known about local connectivity, despite conjectures that local overconnectivity may be causally involved in the disorder. Using functional connectivity MRI and graph theory, we found that local functional connectivity was atypically increased in adolescents with ASD in temporo-occipital regions bilaterally. Posterior overconnectivity was found to be associated with higher ASD symptom severity, whereas an ASD subsample with low severity showed frontal underconnectivity. The findings suggest links between symptomatology and local connectivity, which vary within the autism spectrum.
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•Local brain connectivity is atypically increased in autism in the posterior brain•Some regions in frontal and parietal lobes show local underconnectivity•Connection density correlates with symptom severity in autism
Long-distance neural connectivity in autism spectrum disorders (ASD) is abnormal, but little is known about local connectivity. Using functional connectivity MRI and graph theory in adolescents with ASD, Müller and colleagues find that local connectivity is atypically increased in posterior brain regions bilaterally, associated with higher ASD symptom severity. Conversely, ASD participants with low severity show frontal underconnectivity. The findings suggest regionally abnormal local connectivity and links with symptom severity in ASD. |
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| ISSN: | 2211-1247 |
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| Titel Quelle: | Cell reports (Cambridge) |
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| Jahr Quelle: | 2013 |
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| Band/Heft Quelle: | 5, 3, S. 567-572 |
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| DOI: | doi:10.1016/j.celrep.2013.10.003 |
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| URL: | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fdx.doi.org%2F10.1016%2Fj.celrep.2013.10.003 |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F24210815 |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fsearch.proquest.com%2Fdocview%2F1459558371 |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fsearch.proquest.com%2Fdocview%2F1622613536 |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fpubmed.ncbi.nlm.nih.gov%2FPMC5708538 |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fdoaj.org%2Farticle%2F28dc5f2d50ce41ef94127a251224eff2 |
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| | DOI: https://doi.org/10.1016/j.celrep.2013.10.003 |
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| Sprache: | English |
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| Sach-SW: | Adolescent |
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| | Brain - physiopathology |
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| | Brain Mapping - methods |
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| | Child Development Disorders, Pervasive - etiology |
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| | Child Development Disorders, Pervasive - physiopathology |
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| | Disease Progression |
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| | Female |
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| | Humans |
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| | Male |
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| | Nerve Net - physiopathology |
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| Verknüpfungen: | → Sammelwerk |
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