| |
| Verfasst von: | Kovacs, Stephen B |
|---|---|
| Miao, Edward A | |
| Titel: | Gasdermins: Effectors of Pyroptosis |
| Verlagsort: | England |
| Verlag: | Elsevier Ltd |
| Elsevier BV | |
| Jahr: | 2017 |
| Fussnoten: | ObjectType-Article-2 ; ObjectType-Feature-3 ; ObjectType-Review-1 ; SourceType-Scholarly Journals-1 ; content type line 23 |
| Inhalt: | Pyroptosis is a form of lytic programmed cell death initiated by inflammasomes, which detect cytosolic contamination or perturbation. This drives activation of caspase-1 or caspase-11/4/5, which cleave gasdermin D, separating its N-terminal pore-forming domain (PFD) from the C-terminal repressor domain (RD). The PFD oligomerizes to form large pores in the membrane that drive swelling and membrane rupture. Gasdermin D is one of six (in humans) gasdermin family members; several other gasdermins have also been shown to form pores that cause pyroptosis after cleavage to activate their PFDs. One of these, gasdermin E, is activated by caspase-3 cleavage. We review our current understanding of pyroptosis as well as current knowledge of the gasdermin family. |
| ISSN: | 0962-8924 |
| Titel Quelle: | Trends in cell biology |
| Jahr Quelle: | 2017 |
| Band/Heft Quelle: | 27, 9, S. 673-684 |
| DOI: | doi:10.1016/j.tcb.2017.05.005 |
| URL: | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fwww.clinicalkey.es%2Fplaycontent%2F1-s2.0-S09628924173008 ... |
| http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fdx.doi.org%2F10.1016%2Fj.tcb.2017.05.005 | |
| http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fwww.ncbi.nlm.nih.gov%2Fpubmed%2F28619472 | |
| http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fsearch.proquest.com%2Fdocview%2F1953361227 | |
| http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fsearch.proquest.com%2Fdocview%2F1910792624 | |
| http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fpubmed.ncbi.nlm.nih.gov%2FPMC5565696 | |
| DOI: https://doi.org/10.1016/j.tcb.2017.05.005 | |
| Sprache: | English |
| Sach-SW: | Animals |
| Apoptosis | |
| Apoptosis - physiology | |
| Caspase | |
| Caspase-1 | |
| Caspase-11 | |
| Caspase-3 | |
| Caspases - metabolism | |
| Cell death | |
| Cell Membrane - metabolism | |
| Cells | |
| Cleavage | |
| Contamination | |
| gasdermin | |
| Humans | |
| inflammasome | |
| Inflammasomes | |
| Inflammasomes - metabolism | |
| Membranes | |
| Neoplasm Proteins - metabolism | |
| Oligomerization | |
| Pathology | |
| Pore formation | |
| Pores | |
| programmed cell death | |
| Pyroptosis | |
| Pyroptosis - physiology | |
| Studies | |
| Verknüpfungen: | → Sammelwerk |
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