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Status: 
| Verfasst von: | Alushaj, Erind |
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| | Hemachandra, Dimuthu |
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| | Ganjavi, Hooman |
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| | Seergobin, Ken N |
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| | Sharma, Manas |
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| | Kashgari, Alia |
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| | Barr, Jennifer |
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| | Reisman, William |
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| | Khan, Ali R |
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| | MacDonald, Penny A |
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| Titel: | Increased mean diffusivity of the caudal motor SNc identifies patients with REM sleep behaviour disorder and Parkinson’s disease |
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| Verlagsort: | London |
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| Verlag: | Nature Publishing Group |
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| | Nature Publishing Group UK |
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| Jahr: | 2024 |
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| Fussnoten: | ObjectType-Article-1 ; ObjectType-Feature-2 ; SourceType-Scholarly Journals-1 ; content type line 23 |
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| Inhalt: | Abstract Idiopathic rapid eye movement sleep behaviour disorder (iRBD)—a Parkinson’s disease (PD) prodrome—might exhibit neural changes similar to those in PD. Substantia nigra pars compacta (SNc) degeneration underlies motor symptoms of PD. In iRBD and early PD (ePD), we measured diffusion MRI (dMRI) in the caudal motor SNc, which overlaps the nigrosome-1—the earliest-degenerating dopaminergic neurons in PD—and in the striatum. Nineteen iRBD, 26 ePD (1.7 ± 0.03 years), and 46 age-matched healthy controls (HCs) were scanned at Western University, and 47 iRBD, 115 ePD (0.9 ± 0.01 years), and 56 HCs were scanned through the Parkinson’s Progression Markers Initiative, using 3T MRI. We segmented the SNc and striatum into subregions using automated probabilistic tractography to the cortex. We measured mean diffusivity (MD) and fractional anisotropy (FA) along white-matter bundles and subregional surfaces. We performed group-level and classification analyses. Increased caudal motor SNc surface MD was the only iRBD-HCs and ePD-HCs difference replicating across datasets ( p adj < 0.05). No iRBD-ePD differences emerged. Caudal motor SNc surface MD classified patient groups from HCs at the single-subject level with good-to-excellent balanced accuracy in an independent sample (0.91 iRBD and 0.86 iRBD and ePD combined), compared to fair performance for total SNc surface MD (0.72 iRBD and ePD). Caudal motor SNc surface MD correlated significantly with MDS-UPDRS-III scores in ePD patients. Using dMRI and automated segmentation, we detected changes suggesting altered microstructural integrity in iRBD and ePD in the nigrostriatal sub region known to degenerate first in PD. Surface MD of the caudal motor SNc presents a potential measure for inclusion in neuroimaging biomarkers of iRBD and PD. |
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| ISSN: | 2373-8057 |
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| Titel Quelle: | NPJ Parkinson's Disease |
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| Jahr Quelle: | 2024 |
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| Band/Heft Quelle: | 10, 1, S. 128 |
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| DOI: | doi:10.1038/s41531-024-00731-0 |
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| URL: | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fwww.proquest.com%2Fdocview%2F3074233336%2Fabstract%2F |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fwww.proquest.com%2Fdocview%2F3074725662%2Fabstract%2F |
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| | http://www.ub.uni-heidelberg.de/cgi-bin/edok?dok=https%3A%2F%2Ffanyv88.com%3A443%2Fhttps%2Fpubmed.ncbi.nlm.nih.gov%2FPMC11217278 |
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| | DOI: https://doi.org/10.1038/s41531-024-00731-0 |
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| Sprache: | English |
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| Sach-SW: | Automation |
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