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HIV-Infected Spleens Present Altered Follicular Helper T Cell (Tfh) Subsets and Skewed B Cell Maturation

  • Lucie Colineau ,

    Contributed equally to this work with: Lucie Colineau, Angeline Rouers

    Current address: Department of Medicine, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia, Canada

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, CNRS, ERL 8255, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France

  • Angeline Rouers ,

    Contributed equally to this work with: Lucie Colineau, Angeline Rouers

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, CNRS, ERL 8255, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France

  • Takuya Yamamoto,

    Affiliation Immunology Laboratory, Vaccine research center, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, United States of America

  • Yin Xu,

    Affiliation The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia

  • Alejandra Urrutia,

    Current address: Institut Pasteur, Centre d’Immunologie Humaine, F-75015, Paris, France

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, CNRS, ERL 8255, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France

  • Hang-Phuong Pham,

    Affiliations Sorbonne Universités UPMC Université Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France, INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France, CNRS, FRE3632, Immunology-Immunopathology-Immunotherapy (I3), Paris, France

  • Sylvain Cardinaud,

    Current address: INSERM, U955, IMRB, Vaccine Research Institute, F-94010, Creteil, France

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, CNRS, ERL 8255, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France

  • Assia Samri,

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, AP-HP, Hôpital Pitié-Salpêtière, Department of Immunology, Paris, France

  • Karim Dorgham,

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, AP-HP, Hôpital Pitié-Salpêtière, Department of Immunology, Paris, France

  • Pierre-Grégoire Coulon,

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, CNRS, ERL 8255, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France

  • Rémi Cheynier,

    Affiliations INSERM, U1016, Institut Cochin, Paris, France, CNRS, UMR8104, Paris, France, Université Paris Descartes, Sorbonne Paris Cité, Paris, France

  • Anne Hosmalin,

    Affiliations INSERM, U1016, Institut Cochin, Paris, France, CNRS, UMR8104, Paris, France, Université Paris Descartes, Sorbonne Paris Cité, Paris, France, AP-HP, Hôpital Cochin, Paris, France

  • Eric Oksenhendler,

    Affiliation Université Paris Diderot, Assistance Publique-Hôpitaux de Paris, Département d’Immunologie Clinique, Hôpital Saint-Louis, Paris, France

  • Adrien Six,

    Affiliations Sorbonne Universités UPMC Université Paris 06, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France, INSERM, UMRS 959, Immunology-Immunopathology-Immunotherapy (I3), Paris, France, CNRS, FRE3632, Immunology-Immunopathology-Immunotherapy (I3), Paris, France

  • Anthony D. Kelleher,

    Affiliation The Kirby Institute for Infection and Immunity in Society, University of New South Wales, Sydney, Australia

  • John Zaunders,

    Affiliation St. Vincent's Centre for Applied Medical Research, St. Vincent's Hospital, Sydney, Australia

  • Richard A. Koup,

    Affiliation Immunology Laboratory, Vaccine research center, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, United States of America

  • Brigitte Autran,

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, AP-HP, Hôpital Pitié-Salpêtière, Department of Immunology, Paris, France

  • Arnaud Moris,

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, CNRS, ERL 8255, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, AP-HP, Hôpital Pitié-Salpêtière, Department of Immunology, Paris, France

  •  [ ... ],
  • Stéphanie Graff-Dubois

    [email protected]

    Affiliations Sorbonne Universités, UPMC Université Paris 06, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, INSERM, U1135, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France, CNRS, ERL 8255, Center for Immunology and Microbial Infections—CIMI-Paris, Paris, France

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