Journal of Endocrinology and Metabolism, ISSN 1923-2861 print, 1923-287X online, Open Access |
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Original Article
Volume 14, Number 1, February 2024, pages 40-47
Increased Prevalence of Advanced Metabolic Dysfunction-Associated Steatotic Liver Disease Fibrosis in Type 2 Diabetics Despite Low-Risk Fibrosis-4 Index Scores
Figures
Table
Entire cohort (n = 1,115) | Age < 65 and low risk FIB-4 (n = 609) | Age 65+ and low risk FIB-4 (n = 195) | P value | |
---|---|---|---|---|
Avg: average; BMI: body mass index; CAP: controlled attenuation parameter; LSM: liver stiffness measurement; SD: standard deviation. | ||||
Sex (%) female | 68 | 66 | 61 | NS |
Age (years), Avg (SD) (range) | 53.7 (14.0) (18 - 89) | 45.6 (11.2) (18 - 64) | 70.2 (4.1) (65 - 86) | < 0.0001 |
BMI (kg/m2), Avg (SD) (range) | 35.2 (7.2) (10.6 - 72) | 36.2 (7.4) (10.6 - 72) | 32.5 (6.4) (16.7 - 60.4) | < 0.0001 |
Type 2 diabetes (%) | 39 | 35 | 43 | 0.04 |
HTN (%) | 57 | 54 | 67 | 0.001 |
Dyslipidemia (%) | 57 | 44 | 57 | 0.002 |
AST (IU/L), Avg (SD) (range) | 36.9 (26.7) (7 - 302) | 30.9 (19.1) (7 - 173) | 26.9 (11.8) (8 - 102) | 0.006 |
ALT (IU/L), Avg (SD) (range) | 47.8 (36.5) (6 - 335) | 47.4 (37.8) (6 - 335) | 32.7 (19.6) (7 - 122) | < 0.0001 |
FIB-4, Avg (SD) (range) | 1.32 (0.97) (0.18 - 9.65) | 0.77 (0.26) (0.18 - 1.29) | 1.36 (0.36) (0.3 - 1.99) | < 0.0001 |
LSM (kPa), Avg (SD) (range) | 9.7 (8.4) (2.5 - 75) | 7.9 (4.7) (2.5 - 33.1) | 8.6 (6.9) (2.6 - 75) | < 0.0001 |
CAP (dB/m), Avg (SD) (range) | 333.8 (42.8) (250 - 400) | 336.9 (42.0) (250 - 400) | 321.3 (43.6) (250 - 400) | < 0.0001 |