Wikipedia

RAC1

Rac1 (RAS-related C3 botulinus toxin substrate 1) は、ヒト細胞に存在するタンパク質であり、RAC1遺伝子によりコードされている[5][6]。RAC1は選択的スプライシングにより異なる機能を持ったいくつかのタンパク質を生成しており、このうちの1つがRac1である[7]。

RAC1
PDBに登録されている構造
PDBオルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧

1E96, 1FOE, 1G4U, 1HE1, 1HH4, 1I4D, 1I4L, 1I4T, 1MH1, 1RYF, 1RYH, 2FJU, 2H7V, 2NZ8, 2P2L, 2RMK, 2VRW, 2WKP, 2WKQ, 2WKR, 2YIN, 3B13, 3BJI, 3RYT, 3SBD, 3SBE, 3SU8, 3SUA, 3TH5, 4GZL, 4GZM, 4YON, 5FI0

識別子
記号RAC1, MIG5, Rac-1, TC-25, p21-Rac1, ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1), Rac family small GTPase 1, MRD48
外部IDOMIM: 602048 MGI: 97845 HomoloGene: 69035 GeneCards: RAC1
遺伝子の位置 (ヒト)
7番染色体 (ヒト)
染色体7番染色体 (ヒト)[1]
7番染色体 (ヒト)
RAC1遺伝子の位置
RAC1遺伝子の位置
バンドデータ無し開始点6,374,527 bp[1]
終点6,403,967 bp[1]
遺伝子の位置 (マウス)
5番染色体 (マウス)
染色体5番染色体 (マウス)[2]
5番染色体 (マウス)
RAC1遺伝子の位置
RAC1遺伝子の位置
バンドデータ無し開始点143,489,389 bp[2]
終点143,513,791 bp[2]
RNA発現パターン


さらなる参照発現データ
遺伝子オントロジー
分子機能• ヒストンデアセチラーゼ結合
• Rho GDP-dissociation inhibitor binding
• GTP-dependent protein binding
• GTPase activity
• 酵素結合
• 血漿タンパク結合
• thioesterase binding
• プロテインキナーゼ結合
• ヌクレオチド結合
• GTP binding
• protein serine/threonine kinase activity
• protein-containing complex binding
• phosphatidylinositol-4,5-bisphosphate 3-kinase activity
• ATPase binding
細胞の構成要素• 細胞質
• 細胞質基質
• 膜
• 焦点接着
• メラノソーム
• ruffle membrane
• trans-Golgi network
• 細胞核
• cell projection
• extrinsic component of plasma membrane
• エキソソーム
• 膜状仮足
• early endosome membrane
• 細胞膜
• マイクロフィラメント
• cytoplasmic ribonucleoprotein granule
• endoplasmic reticulum membrane
• ゴルジ膜
• phagocytic cup
• cytoplasmic vesicle
• 細胞外マトリックス
• secretory granule membrane
• 樹状突起スパイン
• recycling endosome membrane
• postsynapse
• glutamatergic synapse
• ficolin-1-rich granule membrane
生物学的プロセス• positive regulation of Rho protein signal transduction
• regulation of respiratory burst
• non-canonical Wnt signaling pathway
• positive regulation of protein phosphorylation
• positive regulation of actin filament polymerization
• regulation of neuron maturation
• negative regulation of receptor-mediated endocytosis
• platelet activation
• Fc-epsilon receptor signaling pathway
• cellular response to mechanical stimulus
• phagocytosis, engulfment
• vascular endothelial growth factor receptor signaling pathway
• substrate adhesion-dependent cell spreading
• 細胞増殖
• ruffle assembly
• lamellipodium assembly
• dopaminergic neuron differentiation
• cell-cell junction organization
• Fc-gamma receptor signaling pathway involved in phagocytosis
• ruffle organization
• actin filament organization
• cell motility
• 解剖学的構造の形態形成
• 骨吸収
• response to wounding
• protein localization to plasma membrane
• 炎症反応
• regulation of small GTPase mediated signal transduction
• positive regulation of cell-substrate adhesion
• Gタンパク質共役受容体シグナル伝達経路
• neuron projection morphogenesis
• epithelial cell morphogenesis
• dendrite morphogenesis
• regulation of hydrogen peroxide metabolic process
• engulfment of apoptotic cell
• 樹状突起発生
• auditory receptor cell morphogenesis
• hyperosmotic response
• cerebral cortex GABAergic interneuron development
• 走化性
• positive regulation of DNA replication
• actin filament polymerization
• 細胞接着
• negative regulation of interleukin-23 production
• homeostasis of number of cells within a tissue
• cell-matrix adhesion
• localization within membrane
• actin cytoskeleton organization
• regulation of cell size
• anatomical structure arrangement
• intracellular signal transduction
• regulation of cell migration
• エンドサイトーシス
• ephrin receptor signaling pathway
• T cell costimulation
• 凝固・線溶系
• mitigation of host defenses by virus
• synaptic transmission, GABAergic
• mast cell chemotaxis
• positive regulation of phosphatidylinositol 3-kinase activity
• positive regulation of substrate adhesion-dependent cell spreading
• embryonic olfactory bulb interneuron precursor migration
• cytoskeleton organization
• cochlea morphogenesis
• positive regulation of neutrophil chemotaxis
• positive regulation of apoptotic process
• regulation of cell morphogenesis
• positive regulation of focal adhesion assembly
• regulation of fibroblast migration
• positive regulation of lamellipodium assembly
• cerebral cortex radially oriented cell migration
• 遊走
• semaphorin-plexin signaling pathway
• positive regulation of stress fiber assembly
• 軸索誘導
• small GTPase mediated signal transduction
• positive regulation of GTPase activity
• Wnt signaling pathway, planar cell polarity pathway
• midbrain dopaminergic neuron differentiation
• neuron migration
• タンパク質リン酸化
• Rho protein signal transduction
• regulation of lamellipodium assembly
• Rac protein signal transduction
• cell projection assembly
• positive regulation of microtubule polymerization
• 好中球脱顆粒
• regulation of nitric oxide biosynthetic process
• phosphatidylinositol phosphate biosynthetic process
• hepatocyte growth factor receptor signaling pathway
• regulation of stress fiber assembly
• positive regulation of protein kinase B signaling
• motor neuron axon guidance
• regulation of neutrophil migration
• positive regulation of insulin secretion involved in cellular response to glucose stimulus
出典:Amigo / QuickGO
オルソログ
種ヒトマウス
Entrez

5879

19353

Ensembl

ENSG00000136238

ENSMUSG00000001847

UniProt

P63000

P63001

RefSeq
(mRNA)

NM_198829
NM_006908
NM_018890

NM_009007
NM_001347530

RefSeq
(タンパク質)

NP_008839
NP_061485

NP_001334459
NP_033033

場所
(UCSC)		Chr 7: 6.37 – 6.4 MbChr 7: 143.49 – 143.51 Mb
PubMed検索[3][4]
ウィキデータ
閲覧/編集 ヒト閲覧/編集 マウス

Rac1は、悪性黒色腫[8][9][10]や肺非小細胞癌[11] を含むさまざまな癌の発生において、重要な役割を果たしていると考えられている。そのため、現在これらの疾患に対する治療標的と考えられている[12]。

機能

編集

低分子量GTPアーゼの1つであるうえ、RhoファミリーGタンパク質であるRacサブファミリーのメンバーでもある。このスーパーファミリーのメンバーは、細胞の増殖や細胞骨格の再構築、プロテインキナーゼの活性化などさまざまな細胞における事象を制御している[13]。

Rac1は、細胞周期や細胞接着、（アクチンネットワークを介した）細胞運動、上皮細胞における悪性形質転換（上皮幹細胞維持における必要物質であると考えられている）などを含む多くの細胞プロセスにおける、多方面的な制御因子である。

相互作用

編集

ARFIP2[14][15][16]、Myotonic dystrophy protein kinase[17]、T-cell lymphoma invasion and metastasis-inducing protein 1[18][19]、PARD6B[20]、PAK1[21][22][23]、PAK3[14]、ARHGDIA[24][25][26][27][28][29]、Myd88[30]、PARD6A,[20][31]、STAT3[32]、IQGAP2[33]、NCKAP1[34]、IQGAP1[23][35][36][37]、FHOD1[38]、BAIAP2[39]、RICS[40][41]、FMNL1[42]などのタンパク質と相互作用することが明らかにされている。

脚注

編集
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000136238 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000001847 - Ensembl, May 2017
  3. ^ Human PubMed Reference:
  4. ^ Mouse PubMed Reference:
  5. ^ Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R (October 1989). “rac, a novel ras-related family of proteins that are botulinum toxin substrates”. J. Biol. Chem. 264 (28): 16378–82. PMID 2674130. 
  6. ^ Jordan P, Brazåo R, Boavida MG, Gespach C, Chastre E (November 1999). “Cloning of a novel human Rac1b splice variant with increased expression in colorectal tumors”. Oncogene 18 (48): 6835–9. doi:10.1038/sj.onc.1203233. PMID 10597294. 
  7. ^ Zhou, C; Licciulli, S; Avila, J L; Cho, M; Troutman, S; Jiang, P; Kossenkov, A V; Showe, L C et al. (2012). “The Rac1 splice form Rac1b promotes K-ras-induced lung tumorigenesis”. Oncogene. doi:10.1038/onc.2012.99. ISSN 0950-9232. 
  8. ^ Hodis, E; Watson, IR; Kryukov, GV; Arold, ST; Imielinski, M; Theurillat, JP; Nickerson, E; Auclair, D; Li, L; Place, C; Dicara, D; Ramos, AH; Lawrence, MS; Cibulskis, K; Sivachenko, A; Voet, D; Saksena, G; Stransky, N; Onofrio, RC; Winckler, W; Ardlie, K; Wagle, N; Wargo, J; Chong, K; Morton, DL; Stemke-Hale, K; Chen, G; Noble, M; Meyerson, M; Ladbury, JE; Davies, MA; Gershenwald, JE; Wagner, SN; Hoon, DS; Schadendorf, D; Lander, ES; Gabriel, SB; Getz, G; Garraway, LA; Chin, L (2012 Jul 18). “A landscape of driver mutations in melanoma.”. Cell. PMID 22817889. 
  9. ^ Krauthammer, M; Kong, Y; Ha, BH; Evans, P; Bacchiocchi, A; McCusker, JP; Cheng, E; Davis, MJ; Goh, G; Choi, M; Ariyan, S; Narayan, D; Dutton-Regester, K; Capatana, A; Holman, EC; Bosenberg, M; Sznol, M; Kluger, HM; Brash, DE; Stern, DF; Materin, MA; Lo, RS; Mane, S; Ma, S; Kidd, KK; Hayward, NK; Lifton, RP; Schlessinger, J; Boggon, TJ; Halaban, R (2012 Jul 29). “Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma.”. Nature genetics. PMID 22842228. 
  10. ^ Bauer, Natalie N.; Chen, Yih-Wen; Samant, Rajeev S.; Shevde, Lalita A.; Fodstad, Oystein (2007). “Rac1 activity regulates proliferation of aggressive metastatic melanoma”. Experimental Cell Research 313 (18): 3832–3839. doi:10.1016/j.yexcr.2007.08.017. ISSN 00144827. 
  11. ^ Stallings-Mann, M. L.; Waldmann, J.; Zhang, Y.; Miller, E.; Gauthier, M. L.; Visscher, D. W.; Downey, G. P.; Radisky, E. S. et al. (2012). “Matrix Metalloproteinase Induction of Rac1b, a Key Effector of Lung Cancer Progression”. Science Translational Medicine 4 (142): 142ra95–142ra95. doi:10.1126/scitranslmed.3004062. ISSN 1946-6234. 
  12. ^ McAllister, S. S. (2012). “Got a Light? Illuminating Lung Cancer”. Science Translational Medicine 4 (142): 142fs22–142fs22. doi:10.1126/scitranslmed.3004446. ISSN 1946-6234. 
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  20. ^ a b Noda, Y; Takeya R, Ohno S, Naito S, Ito T, Sumimoto H (February 2001). “Human homologues of the Caenorhabditis elegans cell polarity protein PAR6 as an adaptor that links the small GTPases Rac and Cdc42 to atypical protein kinase C”. Genes Cells (England) 6 (2): 107–19. doi:10.1046/j.1365-2443.2001.00404.x. ISSN 1356-9597. PMID 11260256. 
  21. ^ Katoh, Hironori; Negishi Manabu (July 2003). “RhoG activates Rac1 by direct interaction with the Dock180-binding protein Elmo”. Nature (England) 424 (6947): 461–4. doi:10.1038/nature01817. PMID 12879077. 
  22. ^ Seoh, Mui Leng; Ng Chong Han, Yong Jeffery, Lim Louis, Leung Thomas (March 2003). “ArhGAP15, a novel human RacGAP protein with GTPase binding property”. FEBS Lett. (Netherlands) 539 (1–3): 131–7. doi:10.1016/S0014-5793(03)00213-8. ISSN 0014-5793. PMID 12650940. 
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  25. ^ Grizot, S; Fauré J, Fieschi F, Vignais P V, Dagher M C, Pebay-Peyroula E (August 2001). “Crystal structure of the Rac1-RhoGDI complex involved in nadph oxidase activation”. Biochemistry (United States) 40 (34): 10007–13. doi:10.1021/bi010288k. ISSN 0006-2960. PMID 11513578. 
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  27. ^ Gorvel, J P; Chang T C, Boretto J, Azuma T, Chavrier P (January 1998). “Differential properties of D4/LyGDI versus RhoGDI: phosphorylation and rho GTPase selectivity”. FEBS Lett. (NETHERLANDS) 422 (2): 269–73. doi:10.1016/S0014-5793(98)00020-9. ISSN 0014-5793. PMID 9490022. 
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推薦文献

編集
  • Benitah SA, Frye M, Glogauer M, Watt FM (2005). “Stem cell depletion through epidermal deletion of Rac1”. Science 309 (5736): 933–5. doi:10.1126/science.1113579. PMID 16081735. 
  • Dorseuil O, Gacon G (1997). “[Signal transduction by Rac small G proteins in phagocytes] [Signal transduction by Rac small G proteins in phagocytes]” (French). C. R. Seances Soc. Biol. Fil. 191 (2): 237–46. PMID 9255350. 
  • Ramakers GJ (2002). “Rho proteins, mental retardation and the cellular basis of cognition”. Trends Neurosci. 25 (4): 191–9. doi:10.1016/S0166-2236(00)02118-4. PMID 11998687. 
  • Esufali S, Charames S, Bapat B (2007). “Suppression of Wnt signalling leads to stabilization of Rac1 isoforms”. FEBS letters. 581 (25): 4850–4856. doi:10.1016/j.febslet.2007.09.013. PMID 17888911. 

外部リンク

編集
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