Hipocalcina

Estruturas dispoñibles
PDB	Buscar ortólogos: PDBe, RCSB
Identificadores
Identificadores; externos	OMIM: 142622 ; MGI: 1336200 ; HomoloGene: 55634 ; EBI: HPCA; GeneCards: Xene HPCA; UniProt: HPCA;
Locus	Cr. 1 p35.1
Ontoloxía Xénica	Referencias: AmiGO / QuickGO
	Referencias: AmiGO / QuickGO
Ortólogos
Especies
Humano	Rato
Entrez
3208	15444
Ensembl
Véxase HS	Véxase MM
UniProt
P84074	P84075
RefSeq; (ARNm)
NM_002143	NM_001130419
RefSeq; (proteína) NCBI
NP_002134	NP_001123891
Localización (UCSC)
Cr. 1:; 32.89 – 32.9 Mb	Cr. 4:; 129.11 – 129.12 Mb
PubMed (Busca)
3208 ;	15444

A hipocalcina é unha proteína que nos humanos está codificada no xene HPCA do cromosoma 1.^[1]^[2]

A hipocalcina é unha proteína que se une ao calcio que pertence á familia de proteínas do sensor de calcio neuronal (NCS).^[3]^[4] Exprésase en cerebros de mamíferos especialmente no hipocampo. Posúe un interruptor Ca²⁺/miristoílo.^[5]

Procesos

A hipocalcina toma parte nos seguintes procesos:

Activación da expresión da PLD1 e PLD2.
Inhibición da apoptose.
Sinalización pola quinase MAP.
Implicación na depresión a longo prazo das neuronas do hipocampo.
Necesaria para a aprendizaxe espacial normal.

Interaccións

A hipocalcina interacciona coas seguintes proteínas:

Proteína inhibidora da apoptose neuronal (NAIP)
Quinase de liñaxe miixta 2 (MLK2) – MLK2 é unha quinase da cadea lixeira da miosina 2
A adaptina b2 do complexo AP2
Proteína activadora dependente do calcio para a secreción (CADPS)

Notas

↑ Takamatsu K, Kobayashi M, Saitoh S, Fujishiro M, Noguchi T (April 1994). "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene". Biochem. Biophys. Res. Commun. 200 (1): 606–11. PMID 8166736. doi:10.1006/bbrc.1994.1491.
↑ Masaki T, Sakai E, Furuta Y, Kobayashi M, Takamatsu K (December 1998). "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes". Gene 225 (1–2): 117–24. PMID 9931466. doi:10.1016/S0378-1119(98)00526-5.
↑ Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. PMC 1887812. PMID 17311005. doi:10.1038/nrn2093.
↑ Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. PMID 15046879. doi:10.1016/j.tins.2004.01.010.
↑ O'Callaghan DW, Tepikin AV, Burgoyne RD (2003). "Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells". J. Cell Biol. 163 (4): 715–721. PMC 2173692. PMID 14638856. doi:10.1083/jcb.200306042.

Véxase twamén

Bibliografía

Hidaka H, Okazaki K (1993). "Neurocalcin family: a novel calcium-binding protein abundant in bovine central nervous system". Neurosci. Res. 16 (2): 73–7. PMID 8387172. doi:10.1016/0168-0102(93)90074-Z.
Nagao M, Hayashi H (2009). "Mixed lineage kinase 2 and hippocalcin are localized in Lewy bodies of Parkinson's disease". J. Neurol. Sci. 281 (1–2): 51–4. PMID 19332348. doi:10.1016/j.jns.2009.02.375.
Kobayashi M, Takamatsu K, Saitoh S, et al. (1992). "Molecular cloning of hippocalcin, a novel calcium-binding protein of the recoverin family exclusively expressed in hippocampus". Biochem. Biophys. Res. Commun. 189 (1): 511–7. PMID 1280427. doi:10.1016/0006-291X(92)91587-G.
Nagata K, Puls A, Futter C, et al. (1998). "The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3". EMBO J. 17 (1): 149–58. PMC 1170366. PMID 9427749. doi:10.1093/emboj/17.1.149.
Kobayashi M, Takamatsu K, Saitoh S, Noguchi T (1993). "Myristoylation of hippocalcin is linked to its calcium-dependent membrane association properties". J. Biol. Chem. 268 (25): 18898–904. PMID 8360179.
Rudinskiy N, Kaneko YA, Beesen AA, et al. (2009). "Diminished hippocalcin expression in Huntington's disease brain does not account for increased striatal neuron vulnerability as assessed in primary neurons". J. Neurochem. 111 (2): 460–72. PMID 19686238. doi:10.1111/j.1471-4159.2009.06344.x.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. PMC 528928. PMID 15489334. doi:10.1101/gr.2596504.
Strausberg RL, Feingold EA, Grouse LH, et al. (2002). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. PMC 139241. PMID 12477932. doi:10.1073/pnas.242603899.
Mercer EA, Korhonen L, Skoglösa Y, et al. (2000). "NAIP interacts with hippocalcin and protects neurons against calcium-induced cell death through caspase-3-dependent and -independent pathways". EMBO J. 19 (14): 3597–607. PMC 313967. PMID 10899114. doi:10.1093/emboj/19.14.3597.
Ivings L, Pennington SR, Jenkins R, et al. (2002). "Identification of Ca2+-dependent binding partners for the neuronal calcium sensor protein neurocalcin delta: interaction with actin, clathrin and tubulin". Biochem. J. 363 (Pt 3): 599–608. PMC 1222513. PMID 11964161. doi:10.1042/0264-6021:3630599.
O'Callaghan DW, Haynes LP, Burgoyne RD (2005). "High-affinity interaction of the N-terminal myristoylation motif of the neuronal calcium sensor protein hippocalcin with phosphatidylinositol 4,5-bisphosphate". Biochem. J. 391 (Pt 2): 231–8. PMC 1276920. PMID 16053445. doi:10.1042/BJ20051001.
O'Callaghan DW, Ivings L, Weiss JL, et al. (2002). "Differential use of myristoyl groups on neuronal calcium sensor proteins as a determinant of spatio-temporal aspects of Ca2+ signal transduction". J. Biol. Chem. 277 (16): 14227–37. PMID 11836243. doi:10.1074/jbc.M111750200.
Markova 0, Fitzgerald D, Stepanyuk A; et al. (2009). "Hippocalcin signaling via site-specific translocation in hippocampal neurons". Neurosci. Lett. 442 (2): 152–7. PMC 2572729. PMID 18634855. doi:10.1016/j.neulet.2008.06.089.

Ligazóns externas

Proteínas NCS

[pmid8166736-1] Takamatsu K, Kobayashi M, Saitoh S, Fujishiro M, Noguchi T (April 1994). "Molecular cloning of human hippocalcin cDNA and chromosomal mapping of its gene". Biochem. Biophys. Res. Commun. 200 (1): 606–11. PMID 8166736. doi:10.1006/bbrc.1994.1491.

[pmid9931466-2] Masaki T, Sakai E, Furuta Y, Kobayashi M, Takamatsu K (December 1998). "Genomic structure and chromosomal mapping of the human and mouse hippocalcin genes". Gene 225 (1–2): 117–24. PMID 9931466. doi:10.1016/S0378-1119(98)00526-5.

[pmid17311005-3] Burgoyne RD (2007). "Neuronal Calcium Sensor Proteins: Generating Diversity in Neuronal Ca2+ Signalling". Nat. Rev. Neurosci. 8 (3): 182–193. PMC 1887812. PMID 17311005. doi:10.1038/nrn2093.

[pmid15046879-4] Burgoyne RD, O'Callaghan DW, Hasdemir B, Haynes LP, Tepikin AV (2004). "Neuronal Ca2+-sensor proteins: multitalented regulators of neuronal function". Trends Neurosci. 27 (4): 203–9. PMID 15046879. doi:10.1016/j.tins.2004.01.010.

[pmid_14638856-5] O'Callaghan DW, Tepikin AV, Burgoyne RD (2003). "Dynamics and calcium sensitivity of the Ca2+/myristoyl switch protein hippocalcin in living cells". J. Cell Biol. 163 (4): 715–721. PMC 2173692. PMID 14638856. doi:10.1083/jcb.200306042.

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