Table of Contents

April 1, 2019; 33 (7-8)

PERSPECTIVE

  • Phasing in heterochromatin during development

    • Robin L. Armstrong and
    • Robert J. Duronio
    Genes Dev. April 1, 2019 33: 379-381; doi:10.1101/gad.324731.119

    In this Perspective, Armstrong and Duronio discuss the findings in this issue of Genes & Developmnet by Seller et al., who developed a new technology for inhibiting maternal gene function to identify the H3K9 methyltransferase necessary for initiating constitutive heterochromatin formation during early Drosophila embryogenesis.

RESEARCH COMMUNICATION

  • Maternal-biased H3K27me3 correlates with paternal-specific gene expression in the human morula

    • Wenhao Zhang,
    • Zhiyuan Chen,
    • Qiangzong Yin,
    • Dan Zhang,
    • Catherine Racowsky,
    • and Yi Zhang
    Genes Dev. April 1, 2019 33: 382-387; Published in Advance February 26, 2019, doi:10.1101/gad.323105.118

    In this study from Zhang et al., the authors found that H3K27me3 is strongly biased toward the maternal allele with some associated with DNA methylation–independent paternally expressed genes (PEGs) in human morulae. Their findings uncover the H3K27me3 landscape and establish a correlation between maternal-biased H3K27me3 and PEGs in human morulae.

RESEARCH PAPERS

  • TGIF transcription factors repress acetyl CoA metabolic gene expression and promote intestinal tumor growth

    • Anant Shah,
    • Tiffany A. Melhuish,
    • Todd E. Fox,
    • Henry F. Frierson, Jr,
    • and David Wotton
    Genes Dev. April 1, 2019 33: 388-402; Published in Advance February 26, 2019, doi:10.1101/gad.320127.118

    In this study, Shah et al. show that Tgifs, which repress gene expression by binding directly to DNA or interacting with transforming growth factor β (TGFβ)-responsive SMADs, promote adenoma growth in the context of mutant Apc (adenomatous polyposis coli). Their findings suggest that Tgifs play an important role in regulating basic energy metabolism in normal cells and that this function of Tgifs is amplified in some cancers.

  • Rapid embryonic cell cycles defer the establishment of heterochromatin by Eggless/SetDB1 in Drosophila

    • Charles A. Seller,
    • Chun-Yi Cho,
    • and Patrick H. O'Farrell
    Genes Dev. April 1, 2019 33: 403-417; Published in Advance February 26, 2019, doi:10.1101/gad.321646.118

    Seller et al. show that developmental slowing of the cell cycle times embryonic heterochromatin formation.

  • CDK12 phosphorylates 4E-BP1 to enable mTORC1-dependent translation and mitotic genome stability

    • Seung H. Choi,
    • Thomas F. Martinez,
    • Seongjae Kim,
    • Cynthia Donaldson,
    • Maxim N. Shokhirev,
    • Alan Saghatelian,
    • and Katherine A. Jones
    Genes Dev. April 1, 2019 33: 418-435; Published in Advance February 28, 2019, doi:10.1101/gad.322339.118

    Here, Choi et al. show that CDK12, the RNA polymerase II C-terminal domain kinase, which regulates genome stability, expression of DNA repair genes, and cancer cell drug resistance, also phosphorylates the mRNA 5′ cap-binding repressor 4E-BP1 to promote translation of mTORC1-dependent mRNAs. Using RIP-seq and Ribo-seq, the authors found that CDK12 regulates binding of eIF4G to many mTORC1 target mRNAs, and identified specific CDK12 “translation-only” target mRNAs.

  • Synergistic lethality between BRCA1 and H3K9me2 loss reflects satellite derepression

    • Jan Padeken,
    • Peter Zeller,
    • Benjamin Towbin,
    • Iskra Katic,
    • Veronique Kalck,
    • Stephen P. Methot,
    • and Susan M. Gasser
    Genes Dev. April 1, 2019 33: 436-451; Published in Advance February 25, 2019, doi:10.1101/gad.322495.118
    OPEN ACCESS ARTICLE

    Padeken et al. performed a genome-wide synthetic lethality screen and show that the BRCA1/BARD1 complex is necessary for germline viability in worms lacking MET-2 but not SET-25. The synthetic sterility upon BRCA1/BARD1 and H3K9me2 loss is directly linked to the DNA damage provoked by unscheduled satellite repeat transcription.

  • The NSL complex-mediated nucleosome landscape is required to maintain transcription fidelity and suppression of transcription noise

    • Kin Chung Lam,
    • Ho-Ryun Chung,
    • Giuseppe Semplicio,
    • Shantanu S. Iyer,
    • Aline Gaub,
    • Vivek Bhardwaj,
    • Herbert Holz,
    • Plamen Georgiev,
    • and Asifa Akhtar
    Genes Dev. April 1, 2019 33: 452-465; Published in Advance February 28, 2019, doi:10.1101/gad.321489.118
    OPEN ACCESS ARTICLE

    In this study, Lam et al. report that the Drosophila nonspecific lethal (NSL) complex is necessary to maintain positioning of nucleosomal organization at gene promoters. Their findings show that the NSL complex establishes a canonical nucleosomal organization that enables transcription and determines TSS fidelity.

  • Auxin regulates endosperm cellularization in Arabidopsis

    • Rita A. Batista,
    • Duarte D. Figueiredo,
    • Juan Santos-González,
    • and Claudia Köhler
    Genes Dev. April 1, 2019 33: 466-476; Published in Advance February 28, 2019, doi:10.1101/gad.316554.118

    Batista et al. show that increased auxin biosynthesis in the endosperm prevents its cellularization, leading to seed arrest.

CORRIGENDUM

  • Corrigendum: Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome

    • Michael N. Corradetti,
    • Ken Inoki,
    • Nabeel Bardeesy,
    • Ronald A. DePinho,
    • and Kun-Liang Guan
    Genes Dev. April 1, 2019 33: 477; doi:10.1101/gad.324970.119
    OPEN ACCESS ARTICLE
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This Issue

April 1, 2019; 33 (7-8)
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  1. PERSPECTIVE
  2. RESEARCH COMMUNICATION
  3. RESEARCH PAPERS
  4. CORRIGENDUM

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