Table of Contents

August 1, 2019; 33 (15-16)

IN THIS ISSUE

  • Note from the Editor

    • Terri Grodzicker
    Genes Dev. August 1, 2019 33: 887; doi:10.1101/gad.330589.119
    OPEN ACCESS ARTICLE

    The special section of review articles below is in honor of the centenary of the Genetics Society.

SPECIAL SECTION: PERSPECTIVE

  • Epigenetics and transcription regulation during eukaryotic diversification: the saga of TFIID

    • Simona V. Antonova,
    • Jeffrey Boeren,
    • H.T. Marc Timmers,
    • and Berend Snel
    Genes Dev. August 1, 2019 33: 888-902; Published in Advance May 23, 2019, doi:10.1101/gad.300475.117

    In this perspective, Antonova et al. determine the evolutionary history of all TFIID subunits and place them in a functional context to understand their diversification. This analysis of TFIID evolution exemplifies how phylogenetic protein interrogation aids in uncovering existing structures, drawing parallels between related complexes and challenges offered by genome expansions that can be countered by exploiting chromatin modifications.

SPECIAL SECTION: REVIEWS

  • PRC2 is high maintenance

    • Jia-Ray Yu,
    • Chul-Hwan Lee,
    • Ozgur Oksuz,
    • James M. Stafford,
    • and Danny Reinberg
    Genes Dev. August 1, 2019 33: 903-935; Published in Advance May 23, 2019, doi:10.1101/gad.325050.119

    In this review, Yu et al. discuss the recent advances in our knowledge of the Polycomb-repressive complex 2 (PRC2) in mammalian systems. They also discuss important discoveries on Polycomb function derived from model organisms such as plants, worms, flies, and some yeast strains in the context of understanding mammalian PRC2 function.

  • Dangerous liaisons: interplay between SWI/SNF, NuRD, and Polycomb in chromatin regulation and cancer

    • Adrian P. Bracken,
    • Gerard L. Brien,
    • and C. Peter Verrijzer
    Genes Dev. August 1, 2019 33: 936-959; Published in Advance May 23, 2019, doi:10.1101/gad.326066.119
    OPEN ACCESS ARTICLE

    In this review, Bracken et al. discuss the functional organization and biochemical activities of remodelers and Polycomb and explore how they work together to control cell differentiation and the maintenance of cell identity. They also discuss how mutations in the genes encoding these various chromatin regulators contribute to oncogenesis by disrupting the chromatin equilibrium.

  • Promoter-proximal pausing of RNA polymerase II: a nexus of gene regulation

    • Leighton Core and
    • Karen Adelman
    Genes Dev. August 1, 2019 33: 960-982; Published in Advance May 23, 2019, doi:10.1101/gad.325142.119

    In this review, Core et al. discuss the recent advances in our understanding of the early steps in Pol II transcription, highlighting the events and factors involved in the establishment and release of paused Pol II. They also discuss a number of unanswered questions about the regulation and function of Pol II pausing.

  • MITF—the first 25 years

    • Colin R. Goding and
    • Heinz Arnheiter
    Genes Dev. August 1, 2019 33: 983-1007; Published in Advance May 23, 2019, doi:10.1101/gad.324657.119

    In this review, Goding and Arnheiter present the current understanding of MITF's role and regulation in development and disease and highlight key areas where our knowledge of MITF regulation and function is limited.

  • Transcription-mediated replication hindrance: a major driver of genome instability

    • Belén Gómez-González and
    • Andrés Aguilera
    Genes Dev. August 1, 2019 33: 1008-1026; Published in Advance May 23, 2019, doi:10.1101/gad.324517.119
    OPEN ACCESS ARTICLE

    In this review, Gómez-González et al. discuss the underlying causes of transcription–replication conflicts, which are major threats to genome integrity. They also discuss mechanisms by which cells resolve these conflicts to sustain genome integrity.

OUTLOOK

  • Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy

    • Rahul S. Samant,
    • Vincent B. Masto,
    • and Judith Frydman
    Genes Dev. August 1, 2019 33: 1027-1030; doi:10.1101/gad.329383.119

    This Outlook discusses the findings by Brennan et al. that degradation and aggregation of nonstoichiometric protein subunits into aggregates are alternative forms of dosage compensation in aneuploid budding yeast and human cell lines.

RESEARCH PAPERS

  • Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells

    • Christopher M. Brennan,
    • Laura Pontano Vaites,
    • Jonathan N. Wells,
    • Stefano Santaguida,
    • Joao A. Paulo,
    • Zuzana Storchova,
    • J. Wade Harper,
    • Joseph A. Marsh,
    • and Angelika Amon
    Genes Dev. August 1, 2019 33: 1031-1047; Published in Advance June 13, 2019, doi:10.1101/gad.327494.119

    In this study, Brennan et al. identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. They propose that proteotoxic stress is a universal feature of aneuploid cells and show that degradation and aggregation of excess polypeptides function as a form of dosage compensation.

  • Enhancement of LIN28B-induced hematopoietic reprogramming by IGF2BP3

    • Saifeng Wang,
    • Bryan Chim,
    • Yijun Su,
    • Pavel Khil,
    • Madeline Wong,
    • Xiantao Wang,
    • Amir Foroushani,
    • Patrick T. Smith,
    • Xiuhuai Liu,
    • Rui Li,
    • Sundar Ganesan,
    • Chrysi Kanellopoulou,
    • Markus Hafner,
    • and Stefan A. Muljo
    Genes Dev. August 1, 2019 33: 1048-1068; Published in Advance June 20, 2019, doi:10.1101/gad.325100.119

    In this study, Wang et al. address the differences between fetal and adult hematopoiesis. By single-cell RNA-seq analysis, the authors show that RNA-binding protein Lin28b alone is insufficient but together with the cytoplasmic RNA-binding protein Igf2bp3 reprograms adult blood cell progenitors to a fetal-like state. Taken together, these observations indicate that Lin28b–Igf2bp3 are developmental regulators that mediate the fetal–adult hematopoietic switch.

  • KLF4 protein stability regulated by interaction with pluripotency transcription factors overrides transcriptional control

    • Navroop K. Dhaliwal,
    • Luis E. Abatti,
    • and Jennifer A. Mitchell
    Genes Dev. August 1, 2019 33: 1069-1082; Published in Advance June 20, 2019, doi:10.1101/gad.324319.119

    In this study, Dhaliwal et al. investigated the transcriptional regulation of the pluripotency transcription factor Klf4 in ES cells and report that posttranslation regulation of KLF4 is tied to its interactions with other pluripotency factors, including NANOG, SOX2, and STAT3. This study implicates protein stabilization as a major factor in maintaining transcriptional control of the pluripotent state.

  • The orphan nuclear receptor SHP regulates ER stress response by inhibiting XBP1s degradation

    • Shengyi Sun,
    • Sherwin Kelekar,
    • Steven A. Kliewer,
    • and David J. Mangelsdorf
    Genes Dev. August 1, 2019 33: 1083-1094; Published in Advance July 11, 2019, doi:10.1101/gad.326868.119

    In this study, Sun et al. investigated the role of the orphan nuclear receptor SHP, a well-known transcriptional corepressor of bile acid and lipid metabolism in the liver, in other tissues. They report that SHP functions as a regulator of ER stress in the exocrine pancreas, specifically via the regulation of XBP1s stability.

|

This Issue

August 1, 2019; 33 (15-16)
Cover
  1. IN THIS ISSUE
  2. SPECIAL SECTION: PERSPECTIVE
  3. SPECIAL SECTION: REVIEWS
  4. OUTLOOK
  5. RESEARCH PAPERS

Find articles in this issue containing these words:

Current Issue

  1. July 1, 2024, 38 (13-14)
  1. Current Issue
  1. Alert me to new issues of G&D

Life Science Alliance