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Santa Cruz Biotechnology, Inc. (SCBT) is a developer of biological products for medical research,[1][2] and is one of the world's largest suppliers of antibodies.[3] Santa Cruz Biotechnology headquarters are located in Dallas, Texas, with additional US facilities in Paso Robles, California,[4] and Sun Valley, Idaho. The company also has international locations in Germany, Shanghai, and Canada.[5] It is focused on the production of research tools and reagents, which also include biochemicals, labware, and CRISPR products.[6]

History

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SCBT was founded in 1991 by Dr. John Stephenson and his wife Brenda Stephenson in Santa Cruz, California.[7] The company was originally headquartered in Santa Cruz, California, where the Stephensons acquired vast tracks of land,[8] and began offering antibodies to the research community.[9] Other products lines were added over the years – siRNAs in 2007,[10] shRNAs in 2009,[11] and laboratory supplies in 2010.

In 2010, the offering of biochemical was expanded from just a few hundred to over 100,000 different products.[12] Products related to CRISPR were introduced in 2015[13] for over 37,000 mouse and human genes.

Santa Cruz Biotechnology has had issues with the USDA for a number of years due to allegations of Animal Welfare Act violations. Three animal-welfare complaints were lodged after inspectors found evidences of animal mistreatment at the company's facility in California.[14] In May 2016, the company settled with the USDA, paying a $3.5 million fine for its alleged violations and agreed to the revocation of its polyclonal antibody dealer license effective from December 31, 2016.[15][14] The fine is considered the largest in the USDA's history.[14]

Santa Cruz Biotechnology is currently the second largest vendor in the antibody market.[8]

References

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  1. ^ "Santa Cruz Biotechnology opens office in Idaho".
  2. ^ "Santa Cruz Biotechnology, Inc.: Private Company Information - Bloomberg". Bloomberg News.
  3. ^ "Economic growth pushes SLO County higher in national ranking".
  4. ^ "Paso Robles Press Santa Cruz Biotech breaks ground on new building".
  5. ^ "Santa Cruz Biotechnology Opens New Office in Canada".
  6. ^ Sterling, John (2023-08-14). "ERS Genomics Inks CRISPR Deal with Santa Cruz Biotechnology". GEN - Genetic Engineering and Biotechnology News. Retrieved 2024-05-08.
  7. ^ "Idaho Mountain Express: Biotechnology firm sets up shop in Ketchum - December 3, 2008".
  8. ^ a b Ferguson, Cat (2014-02-12). "Valuable Antibodies at a High Cost". The New Yorker. ISSN 0028-792X. Retrieved 2024-05-08.
  9. ^ Jeang, K. T.; Chun, R; Lin, N. H.; Gatignol, A; Glabe, C. G.; Fan, H (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". Journal of Virology. 67 (10): 6224–6233. doi:10.1128/JVI.67.10.6224-6233.1993. PMC 238044. PMID 7690421.
  10. ^ Takemura, Yukihiro; Ouchi, Noriyuki; Shibata, Rei; Aprahamian, Tamar; Kirber, Michael T.; Summer, Ross S.; Kihara, Shinji; Walsh, Kenneth (1 February 2007). "Adiponectin modulates inflammatory reactions via calreticulin receptor–dependent clearance of early apoptotic bodies". J Clin Invest. 117 (2): 375–386. doi:10.1172/JCI29709. PMC 1770947. PMID 17256056.
  11. ^ Xiao, Qingzhong; Luo, Zhenling; Pepe, Anna Elena; Margariti, Andriani; Zeng, Lingfang; Xu, Qingbo (1 April 2009). "Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2". American Journal of Physiology. Cell Physiology. 296 (4): C711–C723. doi:10.1152/ajpcell.00442.2008. PMID 19036941. S2CID 22623586 – via ajpcell.physiology.org.
  12. ^ Zucal, Chiara; D’Agostino, Vito G.; Casini, Antonio; Mantelli, Barbara; Thongon, Natthakan; Soncini, Debora; Caffa, Irene; Cea, Michele; Ballestrero, Alberto; Quattrone, Alessandro; Indraccolo, Stefano; Nencioni, Alessio; Provenzani, Alessandro (5 November 2015). "EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition". BMC Cancer. 15: 855. doi:10.1186/s12885-015-1845-1. PMC 4636066. PMID 26542945.
  13. ^ Faddaoui, Adnen; Bachvarova, Magdalena; Plante, Marie; Gregoire, Jean; Renaud, Marie-Claude; Sebastianelli, Alexandra; Gobeil, Stephane; Morin, Chantale; Macdonald, Elizabeth; Vanderhyden, Barbara; Bachvarov, Dimcho (9 February 2016). "The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells". Oncotarget. 7 (12): 14125–14142. doi:10.18632/oncotarget.7288. PMC 4924702. PMID 26871602.
  14. ^ a b c Reardon, Sara (2016). "US government issues historic $3.5-million fine over animal welfare". Nature. doi:10.1038/nature.2016.19958. S2CID 168547955.
  15. ^ "Santa Cruz Biotechnology and the USDA – Speaking of Research". 2023-06-13. Archived from the original on 2023-06-13. Retrieved 2024-01-14.
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