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MBOAT7

From Wikipedia, the free encyclopedia

MBOAT7
Identifiers
AliasesMBOAT7, BB1, LENG4, LPIAT, LRC4, MBOA7, OACT7, hMBOA-7, membrane bound O-acyltransferase domain containing 7, MRT57, LPLAT
External IDsOMIM: 606048; MGI: 1924832; HomoloGene: 11510; GeneCards: MBOAT7; OMA:MBOAT7 - orthologs
EC number2.3.1.n4
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146056
NM_001146082
NM_001146083
NM_024298

NM_029934

RefSeq (protein)

NP_001139528
NP_001139554
NP_001139555
NP_077274

NP_084210

Location (UCSC)Chr 19: 54.17 – 54.19 MbChr 7: 3.68 – 3.7 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Lysophospholipid acyltransferase 7 also known as membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is an enzyme that in humans is encoded by the MBOAT7 gene.[5] It is homologous to other membrane-bound O-acyltransferases.[6][7]

Function

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This gene encodes a member of the membrane-bound O-acyltransferase family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the re-acylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle.[5][6]

References

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  1. ^ a b c ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322 GRCh38: Ensembl release 89: ENSG00000273592, ENSG00000278519, ENSG00000274194, ENSG00000125505, ENSG00000277025, ENSG00000275118, ENSG00000276935, ENSG00000277733, ENSG00000277923, ENSG00000278322Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035596Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ a b "Entrez Gene: Membrane bound O-acyltransferase domain containing 7".
  6. ^ a b Shindou H, Shimizu T (2009). "Acyl-CoA:Lysophospholipid Acyltransferases". Journal of Biological Chemistry. 284 (1): 1–5. doi:10.1074/jbc.R800046200. PMID 18718904.
  7. ^ Wang K, Lee CW, Sui X, Kim S, Wang S, Higgs AB, Baublis AJ, Voth GA, Lao M, Walther TC, Farese Jr RV (2023). "The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification". Nature Communications. 14 (1): 3533. Bibcode:2023NatCo..14.3533W. doi:10.1038/s41467-023-38932-5. PMC 10267149. PMID 37316513. Art. No. 3533.

Further reading

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.