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MAD2L1

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Template:PBB Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.[1][2][3]

Template:PBB Summary

Interactions

MAD2L1 has been shown to interact with MAD2L2,[4] CDC20,[5][6][7][8][9][10][11][12][13][14][15][16] BUB1B,[17] Estrogen receptor beta,[18] ADAM17,[19][20] UBD,[21] CDC27[11][12] and Mad1.[4][8][22]

References

  1. ^ Li Y, Benezra R (October 1996). "Identification of a human mitotic checkpoint gene: hsMAD2". Science. 274 (5285): 246–8. doi:10.1126/science.274.5285.246. PMID 8824189.
  2. ^ Xu L, Deng HX, Yang Y, Xia JH, Hung WY, Siddque T (November 1997). "Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization". Cytogenet Cell Genet. 78 (1): 63–4. doi:10.1159/000134631. PMID 9345911.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)".
  4. ^ a b Murakumo, Y (February 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6). UNITED STATES: 4391–7. doi:10.1074/jbc.275.6.4391. ISSN 0021-9258. PMID 10660610. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  5. ^ Zhang, Y (August 2001). "Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation". Mol. Cell. Biol. 21 (15). United States: 5190–9. doi:10.1128/MCB.21.15.5190-5199.2001. ISSN 0270-7306. PMC 87243. PMID 11438673. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  6. ^ Sihn, Choong-Ryoul (November 2003). "p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells". Cancer Lett. 201 (2). Ireland: 203–10. doi:10.1016/S0304-3835(03)00465-8. ISSN 0304-3835. PMID 14607335. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  7. ^ Luo, X (March 2000). "Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20". Nat. Struct. Biol. 7 (3). UNITED STATES: 224–9. doi:10.1038/73338. ISSN 1072-8368. PMID 10700282. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  8. ^ a b Sironi, L (November 2001). "Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". EMBO J. 20 (22). England: 6371–82. doi:10.1093/emboj/20.22.6371. ISSN 0261-4189. PMC 125308. PMID 11707408. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  9. ^ D'Angiolella, Vincenzo (October 2003). "The spindle checkpoint requires cyclin-dependent kinase activity". Genes Dev. 17 (20). United States: 2520–5. doi:10.1101/gad.267603. ISSN 0890-9369. PMC 218146. PMID 14561775. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  10. ^ Kallio, Marko J (September 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. 158 (5). United States: 841–7. doi:10.1083/jcb.200201135. ISSN 0021-9525. PMC 2173153. PMID 12196507. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  11. ^ a b Wassmann, K (September 1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis". Proc. Natl. Acad. Sci. U.S.A. 95 (19). UNITED STATES: 11193–8. doi:10.1073/pnas.95.19.11193. ISSN 0027-8424. PMC 21618. PMID 9736712. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  12. ^ a b Kallio, M (June 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". J. Cell Biol. 141 (6). UNITED STATES: 1393–406. doi:10.1083/jcb.141.6.1393. ISSN 0021-9525. PMC 2132789. PMID 9628895. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  13. ^ Fang, G (June 1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation". Genes Dev. 12 (12). UNITED STATES: 1871–83. doi:10.1101/gad.12.12.1871. ISSN 0890-9369. PMC 316912. PMID 9637688. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  14. ^ Skoufias, D A (April 2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints". Proc. Natl. Acad. Sci. U.S.A. 98 (8). United States: 4492–7. doi:10.1073/pnas.081076898. ISSN 0027-8424. PMC 31862. PMID 11274370. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  15. ^ Nilsson, Jakob (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12). England: 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  16. ^ Privette, Lisa M (July 2008). "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint". Neoplasia. 10 (7). Canada: 643–52. PMC 2435002. PMID 18592005. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  17. ^ Sudakin, V (September 2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. 154 (5). United States: 925–36. doi:10.1083/jcb.200102093. ISSN 0021-9525. PMC 2196190. PMID 11535616. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  18. ^ Poelzl, G (March 2000). "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad. Sci. U.S.A. 97 (6). UNITED STATES: 2836–9. doi:10.1073/pnas.050580997. ISSN 0027-8424. PMC 16016. PMID 10706629. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  19. ^ Nelson, K K (November 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 Pt 3. ENGLAND: 673–80. doi:10.1042/0264-6021:3430673. ISSN 0264-6021. PMC 1220601. PMID 10527948. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  20. ^ Poghosyan, Zaruhi (February 2002). "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases". J. Biol. Chem. 277 (7). United States: 4999–5007. doi:10.1074/jbc.M107430200. ISSN 0021-9258. PMID 11741929. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)CS1 maint: unflagged free DOI (link)
  21. ^ Liu, Y C (April 1999). "A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2". Proc. Natl. Acad. Sci. U.S.A. 96 (8). UNITED STATES: 4313–8. doi:10.1073/pnas.96.8.4313. ISSN 0027-8424. PMC 16329. PMID 10200259. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  22. ^ Rual, Jean-François (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

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