DEFA6
Template:PBB Human alpha defensin 6 also known as HD-6 is a human protein that is encoded by the DEFA6 gene.[1][2] DEFA6 is expressed in the Paneth cells of the ileum.[3]
Function
The alpha defensins are a family of microbicidal and cytotoxic peptides that defend the host against bacteria and viruses. HD6 is notable because it lacks antibacterial potency while retaining antiviral activity.[4]
Several alpha defensin genes, including DEFA6, are clustered on chromosome 8.[1]
References
- ^ a b "Entrez Gene: DEFA6 defensin, alpha 6, Paneth cell-specific (Homo sapiens)".
- ^ Jones DE, Bevins CL (January 1993). "Defensin-6 mRNA in human Paneth cells: implications for antimicrobial peptides in host defense of the human bowel". FEBS Lett. 315 (2): 187–92. PMID 8417977.
- ^ Zhao C, Wang I, Lehrer RI (24 Nov 1996). "Widespread expression of beta-defensin hBD-1 in human secretory glands and epithelial cells". FEBS Lett. 396 (2–3): 319–22. doi:10.1016/0014-5793(96)01123-4. PMID 8915011.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Ericksen B, Wu Z, Lu W, Lehrer RI. (2005). "Antibacterial activity and specificity of the six human alpha defensins". Antimicrob Agents Chemother. 49 (1): 269–75. doi:10.1128/AAC.49.1.269-275.2005. PMC 538877. PMID 15616305.
{{cite journal}}: CS1 maint: PMC format (link) CS1 maint: multiple names: authors list (link)
Further reading
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