KCNU1
| potassium channel, subfamily U, member 1 | |
|---|---|
| Identifiers | |
| Symbol | KCNU1 |
| Alt. symbols | KCa5.1, Slo3, KCNMC1, Kcnma3 |
| NCBI gene | 157855 |
| HGNC | 18867 |
| RefSeq | NM_001031836 |
| Other data | |
| Locus | Chr. 8 p11.2 |
Potassium channel, subfamily U, member 1, also known as KCNU1, is a gene encoding the KCa5.1 protein.[1].
Although this channel is structurally related to the calcium-activated potassium channels, it cannot be classified as such since it is activated by high intracellular pH and relatively insensitive to changes in calcium concentrations.[2][3][4]
External links
- "Calcium-Activated Potassium Channels: KCa5.1". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology.
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References
- ^ Schreiber M, Wei A, Yuan A, Gaut J, Saito M, Salkoff L (1998). "Slo3, a novel pH-sensitive K+ channel from mammalian spermatocytes". J. Biol. Chem. 273 (6): 3509–16. doi:10.1074/jbc.273.6.3509. PMID 9452476.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link) - ^ Wei AD, Gutman GA, Aldrich R, Chandy KG, Grissmer S, Wulff H (2005). "International Union of Pharmacology. LII. Nomenclature and molecular relationships of calcium-activated potassium channels". Pharmacol Rev. 57 (4): 463–72. doi:10.1124/pr.57.4.9. PMID 16382103.
{{cite journal}}: CS1 maint: multiple names: authors list (link) - ^ Zhang X, Zeng X, Xia XM, Lingle CJ (2006). "pH-regulated Slo3 K+ channels: properties of unitary currents". J. Gen. Physiol. 128 (3): 301–15. doi:10.1085/jgp.200609551. PMC 2151565. PMID 16940554.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link) - ^ Zhang X, Zeng X, Lingle CJ (2006). "Slo3 K+ channels: voltage and pH dependence of macroscopic currents". J. Gen. Physiol. 128 (3): 317–36. doi:10.1085/jgp.200609552. PMC 2151566. PMID 16940555.
{{cite journal}}: Unknown parameter|month=ignored (help)CS1 maint: multiple names: authors list (link)
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