This is the current revision of this page, as edited by DeQuillsta(talk | contribs) at 10:42, 23 July 2024(The "function" section of this article is far too vague and non-specific, describing general qualities of PDZ-domain containing proteins more in-depth than the specific qualities of this protein. Additionally, the function section of this article only relies on a single source.). The present address (URL) is a permanent link to this version.
Revision as of 10:42, 23 July 2024 by DeQuillsta(talk | contribs)(The "function" section of this article is far too vague and non-specific, describing general qualities of PDZ-domain containing proteins more in-depth than the specific qualities of this protein. Additionally, the function section of this article only relies on a single source.)
Proteins containing PDZ domains have been shown frequently to bind the C-termini of transmembrane receptors or ion channels. They have also been shown to bind to other PDZ domain proteins and could possibly be involved in intracellular signalling.[ambiguous] The protein encoded by this gene contains six PDZ domains and shares sequence similarity with pro-interleukin-16 (pro-IL-16). Like pro-IL-16, the encoded protein localizes to the endoplasmic reticulum and is thought to be cleaved by a caspase to produce a secreted peptide containing two PDZ domains. In addition, this gene is upregulated in primary prostate tumors and may be involved in the early stages of prostate tumorigenesis.[6]
Chaib H, Rubin MA, Mucci NR, Li L, Day ML, Rhim JS, Macoska JA (2001). "Activated in prostate cancer: a PDZ domain-containing protein highly expressed in human primary prostate tumors". Cancer Res. 61 (6): 2390–4. PMID11289102.
Ma RY, Tam TS, Suen AP, Yeung PM, Tsang SW, Chung SK, Thomas MK, Leung PS, Yao KM (2006). "Secreted PDZD2 exerts concentration-dependent effects on the proliferation of INS-1E cells". Int. J. Biochem. Cell Biol. 38 (5–6): 1015–22. doi:10.1016/j.biocel.2005.11.012. PMID16413998.