Talastine
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| Formula | C19H21N3O |
| Molar mass | 307.397 g·mol−1 |
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Talastine (trade name Ahanon) is an antihistamine.[1]
Synthesis
[edit]The amide proton from 4-Benzylphalazone is abstracted with KOH, which is then alkylated with dimethylaminoethyl chloride.[2][3]
References
[edit]- ^ Richter G, Kühn E (1990). "[Talastine (Ahanon) as a cause of allergic drug exanthema]". Dermatologische Monatschrift (in German). 176 (2–3): 111–3. PMID 1973126.
- ^ DE 1046625, Engelbrecht, et al., issued 1958, assigned to VEB Deutsches Hydrierwerk Rodleben
- ^ US 3017411, Engelbrecht, et al., issued 1962, assigned to VEB Deutsches Hydrierwerk Rodleben
External links
[edit]- "Talastine". Comparative Toxicogenomics Database.
- Talastine at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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