Matrix-M
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Matrix-M is a saponin-based adjuvant that stimulates humoral and cellular immune responses to vaccines.[1][2]It is composed of material extracted from Quillaja saponaria (soapbox) trees.[3]It is used in a number of vaccines, including the malaria vaccine R21/Matrix-M,[1]influenza vaccines and Novavax's COVID-19 vaccine.[3]
References
- ^ a b Datoo, Mehreen S.; Natama, Magloire H.; Somé, Athanase; Traoré, Ousmane; Rouamba, Toussaint; Bellamy, Duncan; Yameogo, Prisca; Valia, Daniel; Tegneri, Moubarak; Ouedraogo, Florence; Soma, Rachidatou (2021-05-15). "Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial". The Lancet. 397 (10287): 1809–1818. doi:10.1016/S0140-6736(21)00943-0. ISSN 0140-6736. PMID 33964223.
- ^ Magnusson, Sofia E.; Reimer, Jenny M.; Karlsson, Karin H.; Lilja, Lena; Bengtsson, Karin Lövgren; Stertman, Linda (2013-03-25). "Immune enhancing properties of the novel Matrix-M™ adjuvant leads to potentiated immune responses to an influenza vaccine in mice". Vaccine. 31 (13): 1725–1733. doi:10.1016/j.vaccine.2013.01.039. ISSN 0264-410X.
- ^ a b Borrell, Brendan (2020-10-21). "The Tree That Could Help Stop the Pandemic". The Atlantic. Retrieved 2021-10-26.