Matrix-M
Appearance
This article, Matrix-M, has recently been created via the Articles for creation process. Please check to see if the reviewer has accidentally left this template after accepting the draft and take appropriate action as necessary.
Reviewer tools: Inform author |
Matrix-M is a saponin-based adjuvant that stimulates humoral and cellular immune responses to vaccines.[1][2]It is composed of material extracted from Quillaja saponaria (soapbox) trees.[3]It is used in a number of vaccines, including the malaria vaccine R21/Matrix-M,[1]influenza vaccines and Novavax's COVID-19 vaccine.[3]
References
- ^ a b Datoo, Mehreen S.; Natama, Magloire H.; Somé, Athanase; Traoré, Ousmane; Rouamba, Toussaint; Bellamy, Duncan; Yameogo, Prisca; Valia, Daniel; Tegneri, Moubarak; Ouedraogo, Florence; Soma, Rachidatou (2021-05-15). "Efficacy of a low-dose candidate malaria vaccine, R21 in adjuvant Matrix-M, with seasonal administration to children in Burkina Faso: a randomised controlled trial". The Lancet. 397 (10287): 1809–1818. doi:10.1016/S0140-6736(21)00943-0. ISSN 0140-6736. PMID 33964223.
- ^ Magnusson, Sofia E.; Reimer, Jenny M.; Karlsson, Karin H.; Lilja, Lena; Bengtsson, Karin Lövgren; Stertman, Linda (2013-03-25). "Immune enhancing properties of the novel Matrix-M™ adjuvant leads to potentiated immune responses to an influenza vaccine in mice". Vaccine. 31 (13): 1725–1733. doi:10.1016/j.vaccine.2013.01.039. ISSN 0264-410X.
- ^ a b Borrell, Brendan (2020-10-21). "The Tree That Could Help Stop the Pandemic". The Atlantic. Retrieved 2021-10-26.