DNA polymerase eta: Difference between revisions

POLH
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2I5O, 4RNM, 4J9O, 4YQW, 4YR0, 4ECX, 4ECS, 4ECT, 2LSK, 4DL5, 4ECR, 4DL3, 4J9K, 3MR5, 4J9N, 3SI8, 4YP3, 4O3N, 5EWE, 4ECU, 4DL6, 3MR6, 4RNN, 3MR3, 4ECY, 4O3P, 4RNO, 4ECQ, 4O3O, 4O3S, 4ECV, 4J9P, 4Q8F, 4ED3, 4ECZ, 4DL2, 4ECW, 3WUP, 5EWF, 4ED7, 4YR2, 4EEY, 4ED8, 4J9S, 3JAA, 4J9M, 4J9Q, 3MR2, 3TQ1, 4ED6, 4DL7, 4J9R, 4ED0, 4YR3, 4O3Q, 4ED1, 4J9L, 4DL4, 4O3R, 4RU9, 5EWG, 4ED2, 4Q8E, 5KG6, 5DGB, 5KFT, 5DG8, 5KFV, 5KFH, 5KG7, 5KG0, 5KFN, 5KFZ, 5KG1, 5KFX, 5KFC, 5KFU, 5KFA, 5KFK, 5KFI, 5KG4, 5KFQ, 5KFO, 5KFE, 5KFD, 5KFG, 5KG2, 5KFR, 5KFP, 5KG3, 5KFM, 5KFW, 5DGA, 5KFB, 5DG7, 5KFF, 5KFJ, 5DG9, 5L9X, 5KG5, 5KFS, 5KFL, 5KFY
Identifiers
Aliases	POLH, RAD30, RAD30A, XP-V, XPV, DNA polymerase eta, polymerase (DNA) eta
External IDs	OMIM: 603968; MGI: 1891457; HomoloGene: 38189; GeneCards: POLH; OMA:POLH - orthologs
Gene location (Human)
Chr.	Chromosome 6 (human)
End	43,620,523 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	46,513,571 bp
RNA expression pattern
	Top expressed in
	buccal mucosa cell; ; Skeletal muscle tissue of rectus abdominis; ; stromal cell of endometrium; ; trabecular bone; ; lower lobe of lung; ; epithelium of colon; ; nipple; ; tonsil; ; tail of epididymis; ; ventricular zone;
	Top expressed in
	endothelial cell of lymphatic vessel; ; spermatocyte; ; Paneth cell; ; cumulus cell; ; body of femur; ; lumbar spinal ganglion; ; fossa; ; mesenteric lymph nodes; ; human fetus; ; seminal vesicula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; DNA binding; nucleotidyltransferase activity; metal ion binding; damaged DNA binding; protein binding; DNA-directed DNA polymerase activity;
Cellular component	nucleoplasm; nucleus; cytosol; replication fork; site of double-strand break;
Biological process	DNA synthesis involved in DNA repair; pyrimidine dimer repair; DNA biosynthetic process; postreplication repair; error-free translesion synthesis; regulation of DNA repair; cellular response to DNA damage stimulus; DNA replication; cellular response to UV-C; translesion synthesis; response to UV-C; DNA repair; response to radiation; error-prone translesion synthesis;
	Sources:Amigo / QuickGO
Orthologs
	5429
	80905
	ENSG00000170734
	ENSMUSG00000023953
	Q9Y253
	Q9JJN0
	NM_001291969; NM_001291970; NM_006502
	NM_030715; NM_001364947
	NP_001278898; NP_001278899; NP_006493
	NP_109640; NP_001351876
	Wikidata
View/Edit Human	View/Edit Mouse

Browse history interactively

← Previous edit Next edit →

Content deleted Content added

VisualWikitext

Inline

Revision as of 18:51, 11 October 2020

DNA polymerase eta (Pol η), is a protein that in humans is encoded by the POLH gene.^[5]^[6]^[7]

DNA polymerase eta is a eukaryotic DNA polymerase involved in the DNA repair by translesion synthesis. The gene encoding DNA polymerase eta is POLH, also known as XPV, because loss of this gene results in the disease xeroderma pigmentosum. Polymerase eta is particularly important for allowing accurate translesion synthesis of DNA damage resulting from ultraviolet radiation or UV.

Function

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination.^[5]

Bypass of 8-oxoguanine

During DNA replication of the Saccharomyces cerevisiae chromosome, the oxidative DNA damage 8-oxoguanine triggers a switch to translesion synthesis by DNA polymerase eta.^[8] This polymerase replicates 8-oxoguanine with an accuracy (insertion of a cytosine opposite the 8-oxoguanine) of approximately 94%. Replication of 8-oxoguanine in the absence of DNA polymerase eta is less than 40%.

Clinical significance

Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum, characterized by sun sensitivity, elevated incidence of skin cancer, and at the cellular level, by delayed replication and hypermutability after UV-irradiation^[9]^[10]

Interactions

POLH has been shown to interact with PCNA.^[11]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000170734 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000023953 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: POLH polymerase (DNA directed), eta".
^ Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F (June 1999). "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta". Nature. 399 (6737): 700–4. Bibcode:1999Natur.399..700M. doi:10.1038/21447. PMID 10385124. S2CID 4429698.
^ Johnson RE, Kondratick CM, Prakash S, Prakash L (July 1999). "hRAD30 mutations in the variant form of xeroderma pigmentosum". Science. 285 (5425): 263–5. doi:10.1126/science.285.5425.263. PMID 10398605.
^ Rodriguez GP, Song JB, Crouse GF (2013). "In vivo bypass of 8-oxodG". PLOS Genet. 9 (8): e1003682. doi:10.1371/journal.pgen.1003682. PMC 3731214. PMID 23935538.{{cite journal}}: CS1 maint: unflagged free DOI (link)
^ Stary A, Sarasin A (September 2002). "Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells". Res. Microbiol. 153 (7): 441–5. doi:10.1016/S0923-2508(02)01343-8. PMID 12405351.
^ Cruet-Hennequart S, Gallagher K, Sokòl AM, Villalan S, Prendergast AM, Carty MP (2010). "DNA Polymerase η, a Key Protein in Translesion Synthesis in Human Cells". DNA polymerase eta, a key protein in translesion synthesis in human cells. Subcellular Biochemistry. Vol. 50. pp. 189–209. doi:10.1007/978-90-481-3471-7_10. ISBN 978-90-481-3470-0. PMID 20012583.
^ Haracska L, Johnson RE, Unk I, Phillips B, Hurwitz J, Prakash L, Prakash S (November 2001). "Physical and functional interactions of human DNA polymerase eta with PCNA". Mol. Cell. Biol. 21 (21): 7199–206. doi:10.1128/MCB.21.21.7199-7206.2001. PMC 99895. PMID 11585903.

External links

GeneReviews/NIH/NCBI/UW entry on Xeroderma Pigmentosum

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000170734 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000023953 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: POLH polymerase (DNA directed), eta".

[pmid10385124-6] Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F (June 1999). "The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta". Nature. 399 (6737): 700–4. Bibcode:1999Natur.399..700M. doi:10.1038/21447. PMID 10385124. S2CID 4429698.

[pmid10398605-7] Johnson RE, Kondratick CM, Prakash S, Prakash L (July 1999). "hRAD30 mutations in the variant form of xeroderma pigmentosum". Science. 285 (5425): 263–5. doi:10.1126/science.285.5425.263. PMID 10398605.

[pmid23935538-8] Rodriguez GP, Song JB, Crouse GF (2013). "In vivo bypass of 8-oxodG". PLOS Genet. 9 (8): e1003682. doi:10.1371/journal.pgen.1003682. PMC 3731214. PMID 23935538.{{cite journal}}: CS1 maint: unflagged free DOI (link)

[pmid12405351-9] Stary A, Sarasin A (September 2002). "Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells". Res. Microbiol. 153 (7): 441–5. doi:10.1016/S0923-2508(02)01343-8. PMID 12405351.

[pmid20012583-10] Cruet-Hennequart S, Gallagher K, Sokòl AM, Villalan S, Prendergast AM, Carty MP (2010). "DNA Polymerase η, a Key Protein in Translesion Synthesis in Human Cells". DNA polymerase eta, a key protein in translesion synthesis in human cells. Subcellular Biochemistry. Vol. 50. pp. 189–209. doi:10.1007/978-90-481-3471-7_10. ISBN 978-90-481-3470-0. PMID 20012583.

[pmid11585903-11] Haracska L, Johnson RE, Unk I, Phillips B, Hurwitz J, Prakash L, Prakash S (November 2001). "Physical and functional interactions of human DNA polymerase eta with PCNA". Mol. Cell. Biol. 21 (21): 7199–206. doi:10.1128/MCB.21.21.7199-7206.2001. PMC 99895. PMID 11585903.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]

[9]

[10]

[11]

@@ Line 1: / Line 1: @@
 {{Infobox_gene}}
-'''DNA polymerase eta''' ('''Pol η'''), is a [[protein]] that in humans is encoded by the ''POLH'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POLH polymerase (DNA directed), eta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5429| accessdate = }}</ref><ref name="pmid10385124">{{cite journal | vauthors = Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F | title = The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta | journal = Nature | volume = 399 | issue = 6737 | pages = 700–4  | date = June 1999 | pmid = 10385124 | doi = 10.1038/21447 }}</ref><ref name="pmid10398605">{{cite journal | vauthors = Johnson RE, Kondratick CM, Prakash S, Prakash L | title = hRAD30 mutations in the variant form of xeroderma pigmentosum | journal = Science | volume = 285 | issue = 5425 | pages = 263–5  | date = July 1999 | pmid = 10398605 | doi = 10.1126/science.285.5425.263 }}</ref>
+'''DNA polymerase eta''' ('''Pol η'''), is a [[protein]] that in humans is encoded by the ''POLH'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: POLH polymerase (DNA directed), eta| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5429| accessdate = }}</ref><ref name="pmid10385124">{{cite journal | vauthors = Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F | title = The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta | journal = Nature | volume = 399 | issue = 6737 | pages = 700–4  | date = June 1999 | pmid = 10385124 | doi = 10.1038/21447 | bibcode = 1999Natur.399..700M | s2cid = 4429698 }}</ref><ref name="pmid10398605">{{cite journal | vauthors = Johnson RE, Kondratick CM, Prakash S, Prakash L | title = hRAD30 mutations in the variant form of xeroderma pigmentosum | journal = Science | volume = 285 | issue = 5425 | pages = 263–5  | date = July 1999 | pmid = 10398605 | doi = 10.1126/science.285.5425.263 }}</ref>
 DNA polymerase eta is a eukaryotic [[DNA polymerase]] involved in the [[DNA repair#Translesion synthesis|DNA repair by translesion synthesis]]. The gene encoding DNA polymerase eta is [[POLH]], also known as XPV, because loss of this gene results in the disease [[xeroderma pigmentosum]].  Polymerase eta is particularly important for allowing accurate translesion synthesis of DNA damage resulting from ultraviolet radiation or UV.
@@ Line 13: / Line 13: @@
 == Clinical significance ==
-Mutations in this gene result in XPV, a variant type of [[xeroderma pigmentosum]], characterized by sun sensitivity, elevated incidence of skin cancer, and at the cellular level, by delayed replication and hypermutability after UV-irradiation<ref name="pmid12405351">{{cite journal | vauthors = Stary A, Sarasin A | title = Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells | journal = Res. Microbiol. | volume = 153 | issue = 7 | pages = 441–5  | date = September 2002 | pmid = 12405351 | doi = 10.1016/S0923-2508(02)01343-8 }}</ref><ref name="pmid20012583">{{cite journal | vauthors = Cruet-Hennequart S, Gallagher K, Sokòl AM, Villalan S, Prendergast AM, Carty MP | title = DNA polymerase eta, a key protein in translesion synthesis in human cells | volume = 50 | issue = | pages = 189–209 | year = 2010 | pmid = 20012583 | doi = 10.1007/978-90-481-3471-7_10 | series = Subcellular Biochemistry | isbn = 978-90-481-3470-0 }}</ref>
+Mutations in this gene result in XPV, a variant type of [[xeroderma pigmentosum]], characterized by sun sensitivity, elevated incidence of skin cancer, and at the cellular level, by delayed replication and hypermutability after UV-irradiation<ref name="pmid12405351">{{cite journal | vauthors = Stary A, Sarasin A | title = Molecular mechanisms of UV-induced mutations as revealed by the study of DNA polymerase eta in human cells | journal = Res. Microbiol. | volume = 153 | issue = 7 | pages = 441–5  | date = September 2002 | pmid = 12405351 | doi = 10.1016/S0923-2508(02)01343-8 }}</ref><ref name="pmid20012583">{{cite book | vauthors = Cruet-Hennequart S, Gallagher K, Sokòl AM, Villalan S, Prendergast AM, Carty MP | title = DNA polymerase eta, a key protein in translesion synthesis in human cells | chapter = DNA Polymerase η, a Key Protein in Translesion Synthesis in Human Cells | volume = 50 | pages = 189–209 | year = 2010 | pmid = 20012583 | doi = 10.1007/978-90-481-3471-7_10 | series = Subcellular Biochemistry | isbn = 978-90-481-3470-0 }}</ref>
 == Interactions ==
@@ Line 26: / Line 26: @@
 * {{cite journal | vauthors =  Plachta M, Halas, McIntyre J, Sledziewska-Gojska E | title = The steady-state level and stability of TLS polymerase eta are cellcycle dependent in the yeast S. cerevisiae | journal = DNA Repair | volume = 29 | pages = 147–153 | year = 2015 | doi = 10.1016/j.dnarep.2015.02.015 |pmid = 25766643 | url = http://eprints.ibb.waw.pl/954/1/Pol%20eta%20revision%20final.doc }}
 * {{cite journal | vauthors = Skoneczna A, McIn Atyre J, Skoneczny M, Policinska Z, Sledziewska-Gojska E | title = Polymerase eta is a short-lived, proteasomally degraded protein that is temporarily stabilized following UV irradiation in Saccharomyces cerevisiae | journal = J. Mol. Biol. | volume = 366 | issue = 4 | pages = 1074–86 | year = 2007 | pmid = 17198712 | doi = 10.1016/j.jmb.2006.11.093 }}
-* {{cite journal | vauthors = Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F | title = The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta | journal = Nature | volume = 399 | issue = 6737 | pages = 700–4 | year = 1999 | pmid = 10385124 | doi = 10.1038/21447 }}
+* {{cite journal | vauthors = Masutani C, Kusumoto R, Yamada A, Dohmae N, Yokoi M, Yuasa M, Araki M, Iwai S, Takio K, Hanaoka F | title = The XPV (xeroderma pigmentosum variant) gene encodes human DNA polymerase eta | journal = Nature | volume = 399 | issue = 6737 | pages = 700–4 | year = 1999 | pmid = 10385124 | doi = 10.1038/21447 | bibcode = 1999Natur.399..700M | s2cid = 4429698 }}
 * {{cite journal | vauthors = Johnson RE, Kondratick CM, Prakash S, Prakash L | title = hRAD30 mutations in the variant form of xeroderma pigmentosum | journal = Science | volume = 285 | issue = 5425 | pages = 263–5 | year = 1999 | pmid = 10398605 | doi = 10.1126/science.285.5425.263 }}
 * {{cite journal | vauthors = Masutani C, Kusumoto R, Iwai S, Hanaoka F | title = Mechanisms of accurate translesion synthesis by human DNA polymerase eta | journal = EMBO J. | volume = 19 | issue = 12 | pages = 3100–9 | year = 2000 | pmid = 10856253 | pmc = 203367 | doi = 10.1093/emboj/19.12.3100 }}
@@ Line 32: / Line 32: @@
 * {{cite journal | vauthors = Yuasa M, Masutani C, Eki T, Hanaoka F | title = Genomic structure, chromosomal localization and identification of mutations in the xeroderma pigmentosum variant (XPV) gene | journal = Oncogene | volume = 19 | issue = 41 | pages = 4721–8 | year = 2000 | pmid = 11032022 | doi = 10.1038/sj.onc.1203842 | doi-access = free }}
 * {{cite journal | vauthors = Itoh T, Linn S, Kamide R, Tokushige H, Katori N, Hosaka Y, Yamaizumi M | title = Xeroderma pigmentosum variant heterozygotes show reduced levels of recovery of replicative DNA synthesis in the presence of caffeine after ultraviolet irradiation | journal = J. Invest. Dermatol. | volume = 115 | issue = 6 | pages = 981–5 | year = 2000 | pmid = 11121129 | doi = 10.1046/j.1523-1747.2000.00154.x }}
-* {{cite journal | vauthors = Zeng X, Winter DB, Kasmer C, Kraemer KH, Lehmann AR, Gearhart PJ | title = DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes | journal = Nat. Immunol. | volume = 2 | issue = 6 | pages = 537–41 | year = 2001 | pmid = 11376341 | doi = 10.1038/88740 }}
+* {{cite journal | vauthors = Zeng X, Winter DB, Kasmer C, Kraemer KH, Lehmann AR, Gearhart PJ | title = DNA polymerase eta is an A-T mutator in somatic hypermutation of immunoglobulin variable genes | journal = Nat. Immunol. | volume = 2 | issue = 6 | pages = 537–41 | year = 2001 | pmid = 11376341 | doi = 10.1038/88740 | s2cid = 6213513 }}
 * {{cite journal | vauthors = Matsuda T, Bebenek K, Masutani C, Rogozin IB, Hanaoka F, Kunkel TA | title = Error rate and specificity of human and murine DNA polymerase eta | journal = J. Mol. Biol. | volume = 312 | issue = 2 | pages = 335–46 | year = 2001 | pmid = 11554790 | doi = 10.1006/jmbi.2001.4937 | url = https://zenodo.org/record/1229894 }}
 * {{cite journal | vauthors = Haracska L, Johnson RE, Unk I, Phillips B, Hurwitz J, Prakash L, Prakash S | title = Physical and functional interactions of human DNA polymerase eta with PCNA | journal = Mol. Cell. Biol. | volume = 21 | issue = 21 | pages = 7199–206 | year = 2001 | pmid = 11585903 | pmc = 99895 | doi = 10.1128/MCB.21.21.7199-7206.2001 }}
 * {{cite journal | vauthors = Glick E, Vigna KL, Loeb LA | title = Mutations in human DNA polymerase eta motif II alter bypass of DNA lesions | journal = EMBO J. | volume = 20 | issue = 24 | pages = 7303–12 | year = 2001 | pmid = 11743006 | pmc = 125802 | doi = 10.1093/emboj/20.24.7303 }}
-* {{cite journal | vauthors = Limoli CL, Giedzinski E, Bonner WM, Cleaver JE | title = UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 1 | pages = 233–8 | year = 2002 | pmid = 11756691 | pmc = 117544 | doi = 10.1073/pnas.231611798 }}
+* {{cite journal | vauthors = Limoli CL, Giedzinski E, Bonner WM, Cleaver JE | title = UV-induced replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gamma -H2AX formation, and Mre11 relocalization | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 1 | pages = 233–8 | year = 2002 | pmid = 11756691 | pmc = 117544 | doi = 10.1073/pnas.231611798 | bibcode = 2002PNAS...99..233L }}
-* {{cite journal | vauthors = Broughton BC, Cordonnier A, Kleijer WJ, Jaspers NG, Fawcett H, Raams A, Garritsen VH, Stary A, Avril MF, Boudsocq F, Masutani C, Hanaoka F, Fuchs RP, Sarasin A, Lehmann AR | title = Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 2 | pages = 815–20 | year = 2002 | pmid = 11773631 | pmc = 117388 | doi = 10.1073/pnas.022473899 }}
+* {{cite journal | vauthors = Broughton BC, Cordonnier A, Kleijer WJ, Jaspers NG, Fawcett H, Raams A, Garritsen VH, Stary A, Avril MF, Boudsocq F, Masutani C, Hanaoka F, Fuchs RP, Sarasin A, Lehmann AR | title = Molecular analysis of mutations in DNA polymerase eta in xeroderma pigmentosum-variant patients | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 99 | issue = 2 | pages = 815–20 | year = 2002 | pmid = 11773631 | pmc = 117388 | doi = 10.1073/pnas.022473899 | bibcode = 2002PNAS...99..815B }}
 * {{cite journal | vauthors = Chiapperino D, Kroth H, Kramarczuk IH, Sayer JM, Masutani C, Hanaoka F, Jerina DM, Cheh AM | title = Preferential misincorporation of purine nucleotides by human DNA polymerase eta opposite benzo[a]pyrene 7,8-diol 9,10-epoxide deoxyguanosine adducts | journal = J. Biol. Chem. | volume = 277 | issue = 14 | pages = 11765–71 | year = 2002 | pmid = 11821420 | doi = 10.1074/jbc.M112139200 | doi-access = free }}
 * {{cite journal | vauthors = Kusumoto R, Masutani C, Iwai S, Hanaoka F | title = Translesion synthesis by human DNA polymerase eta across thymine glycol lesions | journal = Biochemistry | volume = 41 | issue = 19 | pages = 6090–9 | year = 2002 | pmid = 11994004 | doi = 10.1021/bi025549k }}