SARS-CoV-2: Difference between revisions
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{{Use dmy dates|date=January 2020}} |
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{{current}} |
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{{Medical citations needed|date=January 2020}} |
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{{Virusbox |
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| image = |
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| image_alt = |
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| image_caption = IVDC, China CDC: Wuhan coronavirus |
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| parent = Incertae sedis/Betacoronavirus |
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| virus = Novel coronavirus (2019-nCoV) |
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| subdivision_ranks = |
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| subdivision_ref = |
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| subdivision = |
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| synonyms = |
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* Wuhan seafood market pneumonia virus |
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* Wuhan pneumonia |
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* Wuhan coronavirus |
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| synonyms_ref = |
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| range_map = File:Wuhan China.png |
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| range_map_caption = Wuhan, China; primary location of the only recorded outbreak |
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}} |
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{{Infobox genome |
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| image = <!-- Karyotype, for instance --> |
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| caption = |
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| type = nucleotide |
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| taxId = MN908947 |
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| ploidy = <!-- haploid, diploid or polypoloid --> |
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| chromosomes = <!-- number (unit is pairs) --> |
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| size = 30473 bp |
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| year = 2020 |
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}} |
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'''Novel coronavirus''', denoted '''2019-nCoV''' by the [[World Health Organization|WHO]]<ref>{{Cite web|url=https://www.who.int/publications-detail/surveillance-case-definitions-for-human-infection-with-novel-coronavirus-(ncov)|title=Surveillance case definitions for human infection with novel coronavirus (nCoV)|website=www.who.int|language=en|access-date=2020-01-21}}</ref><ref>{{cite web|url=https://www.cdc.gov/coronavirus/novel-coronavirus-2019.html|title=Novel coronavirus (2019-nCoV), Wuhan, China|last=|first=|date=10 January 2020|website=|publisher=cdc.gov|url-status=live|archive-url=|archive-date=|accessdate=16 January 2020}}</ref> and also known as '''Wuhan coronavirus''', '''Wuhan seafood market pneumonia virus''' and '''Wuhan pneumonia''',<ref name="MN908947">{{cite journal |last1=Zhang |first1=Y.-Z. |display-authors=etal |title=Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome |url=https://www.ncbi.nlm.nih.gov/nuccore/MN908947 |website=GenBank |accessdate=13 January 2020 |location=Bethesda MD |language=en |date=12 January 2020}}</ref> is a [[Positive-sense single-stranded RNA virus|positive-sense, single-stranded RNA]] [[coronavirus]] first reported in 2019. The virus was [[genomically sequenced]] after [[nucleic acid test]]ing on a positive patient sample in a patient with [[pneumonia]] during the [[2019-20 outbreak of novel coronavirus (2019-nCoV)|2019–2020 Wuhan pneumonia outbreak]].<ref>{{cite web|url=http://www.chinacdc.cn/dfdt/201912/t20191226_209404.html|title=中国疾病预防控制中心|website=www.chinacdc.cn|access-date=9 January 2020}}</ref><ref name=":0">{{cite web|url=http://www.xinhuanet.com/english/2020-01/09/c_138690570.htm|title=New-type coronavirus causes pneumonia in Wuhan: expert – Xinhua {{!}} English.news.cn|website=www.xinhuanet.com|access-date=9 January 2020}}</ref><ref name=":1">{{cite web|url=https://platform.gisaid.org/epi3/start/CoV2020|title=CoV2020|last=|first=|date=|website=platform.gisaid.org|url-status=live|archive-url=|archive-date=|access-date=12 January 2020}}</ref> |
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On 20 January 2020, human-to-human transmission was confirmed in [[Guangdong|Guangdong province]], [[China]], according to [[Zhong Nanshan]], head of the health commission team investigating the outbreak.<ref>{{Cite news|url=https://www.cbc.ca/news/health/coronavirus-human-to-human-1.5433187|title=China confirms human-to-human transmission of new coronavirus|last=|first=|date=Jan 20, 2020|work=CBC News|access-date=2020-01-21|url-status=live}}</ref> No specific treatment for the new virus is currently available, but existing [[antiviral drug|anti-virals]] could be [[drug repositioning|repurposed]].<ref>{{Cite news|url=https://www.reuters.com/article/us-china-health-pneumonia-who-idUSKBN1ZD16J|title=WHO says new China coronavirus could spread, warns hospitals worldwide|date=2020-01-14|work=Reuters|access-date=2020-01-21|language=en}}</ref> |
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The virus has spread to [[Bangkok]], [[Tokyo]], [[South Korea]], [[Beijing]], [[Shanghai]], [[Guangdong Province]], [[Taiwan]], and [[Washington state|Washington State]]<ref>{{cite web |title=China Virus Spreads to U.S. With Health Officials on High Alert|url=https://www.bloomberg.com/news/articles/2020-01-21/china-virus-s-spread-puts-global-health-officials-on-high-alert |website=Bloomberg |accessdate=21 January 2020}}</ref> in the United States. There have been 6 fatalities and 317 known cases.<ref>{{cite web |title=Wuhan virus: China reports fourth death in pneumonia outbreak; 15 medical workers infected |url=https://www.straitstimes.com/asia/east-asia/china-says-fourth-person-dies-in-wuhan-pneumonia-outbreak |website=straitstimes |accessdate=20 January 2020}}</ref> A suspected case has been reported from Brisbane, Australia, but has not yet been confirmed.<ref>{{cite web |title=Wuhan virus: Australia testing first suspected case, to start screening passengers from Wuhan|url=https://www.straitstimes.com/asia/australianz/wuhan-virus-australia-to-screen-some-flights-from-china-warns-coronavirus-difficult |website=The Straits Times |accessdate=21 January 2020}}</ref> |
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==Phylogenetics== |
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Sequences of Wuhan betacoronavirus show similarities to [[betacoronavirus]]es found in [[bat]]s; however, the virus is genetically distinct from other [[coronavirus]]es such as ''[[Severe acute respiratory syndrome-related coronavirus]]'' (SARS) and ''[[Middle East respiratory syndrome-related coronavirus]]'' (MERS).<ref name=":1" /> Like SARS-CoV, it is a member of Beta-CoV lineage B.<ref>{{cite web |title=Phylogeny of SARS-like betacoronaviruses |url=https://nextstrain.org/groups/blab/sars-like-cov |website=nextstrain |accessdate=18 January 2020}}</ref> |
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Five genomes of the novel coronavirus have been isolated and reported including BetaCoV/Wuhan/IVDC-HB-01/2019, BetaCoV/Wuhan/IVDC-HB-04/2020, BetaCoV/Wuhan/IVDC-HB-05/2019, BetaCoV/Wuhan/WIV04/2019, and BetaCoV/Wuhan/IPBCAMS-WH-01/2019 from the [[Chinese Center for Disease Control and Prevention|China CDC]] [[National Institute for Viral Disease Control and Prevention]], [[Institute of Pathogen Biology]], and [[Wuhan Jinyintan Hospital]].<ref name=":1" /><ref>{{cite web|url=http://virological.org/t/initial-genome-release-of-novel-coronavirus/319|title=Initial genome release of novel coronavirus|date=11 January 2020|website=Virological|language=en-US|access-date=12 January 2020}}</ref><ref>{{Cite journal|date=2020-01-17|title=Wuhan seafood market pneumonia virus isolate Wuhan-Hu-1, complete genome|url=http://www.ncbi.nlm.nih.gov/nuccore/MN908947.3|language=en-US}}</ref> Its [[RNA]] sequence is approximately 30 [[Base pair#Length measurements|kbp]] in length.<ref name=":1" /> |
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==See also== |
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Diseases caused by genetically similar viruses: |
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* [[Severe acute respiratory syndrome|Severe acute respiratory syndrome (SARS)]] |
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* [[Middle East respiratory syndrome|Middle East respiratory syndrome (MERS)]] |
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==References== |
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{{Reflist|2}} |
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==External links== |
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{{Portal|Viruses}} |
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* {{Commons category-inline}} |
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* {{Wiktionary-inline|Wuhan pneumonia}} |
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{{Viral systemic diseases|state=collapsed}} |
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{{Taxonbar|from=Q82069695}} |
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[[Category:Betacoronaviruses]] |
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[[Category:Unaccepted virus taxa]] |
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