Jump to content

NLRP4: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
m →‎top: Task 23: Replace Template:PBB Summary per TfD
Line 3: Line 3:
'''NACHT, LRR and PYD domains-containing protein 4''' is a [[protein]] that in humans is encoded by the ''NLRP4'' [[gene]].<ref name="pmid12563287">{{cite journal |vauthors=Tschopp J, Martinon F, Burns K | title = NALPs: a novel protein family involved in inflammation | journal = Nat Rev Mol Cell Biol | volume = 4 | issue = 2 | pages = 95–104 |date=Feb 2003 | pmid = 12563287 | pmc = | doi = 10.1038/nrm1019 }}</ref><ref name="pmid12019269">{{cite journal |vauthors=Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J | title = PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing | journal = J Biol Chem | volume = 277 | issue = 33 | pages = 29874–80 |date=Aug 2002 | pmid = 12019269 | pmc = | doi = 10.1074/jbc.M203915200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLRP4 NLR family, pyrin domain containing 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147945| accessdate = }}</ref>
'''NACHT, LRR and PYD domains-containing protein 4''' is a [[protein]] that in humans is encoded by the ''NLRP4'' [[gene]].<ref name="pmid12563287">{{cite journal |vauthors=Tschopp J, Martinon F, Burns K | title = NALPs: a novel protein family involved in inflammation | journal = Nat Rev Mol Cell Biol | volume = 4 | issue = 2 | pages = 95–104 |date=Feb 2003 | pmid = 12563287 | pmc = | doi = 10.1038/nrm1019 }}</ref><ref name="pmid12019269">{{cite journal |vauthors=Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J | title = PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing | journal = J Biol Chem | volume = 277 | issue = 33 | pages = 29874–80 |date=Aug 2002 | pmid = 12019269 | pmc = | doi = 10.1074/jbc.M203915200 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: NLRP4 NLR family, pyrin domain containing 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=147945| accessdate = }}</ref>


⚫
NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]<ref name="entrez" />
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
⚫
| summary_text = NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM]<ref name="entrez" />
}}


==References==
==References==

Revision as of 22:41, 7 April 2019

NLRP4
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesNLRP4, CLR19.5, CT58, NALP4, PAN2, PYPAF4, RNH2, NLR family, pyrin domain containing 4, NLR family pyrin domain containing 4
External IDsOMIM: 609645; MGI: 1890518; HomoloGene: 75315; GeneCards: NLRP4; OMA:NLRP4 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

147945

83564

Ensembl

ENSG00000160505

ENSMUSG00000034690

UniProt

Q96MN2

Q3TKR3

RefSeq (mRNA)

NM_134444

NM_031389

RefSeq (protein)

NP_604393

NP_113566

Location (UCSC)Chr 19: 55.84 – 55.88 MbChr 7: 6.05 – 6.11 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

NACHT, LRR and PYD domains-containing protein 4 is a protein that in humans is encoded by the NLRP4 gene.[5][6][7]

NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003).[supplied by OMIM][7]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000160505 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000034690 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Tschopp J, Martinon F, Burns K (Feb 2003). "NALPs: a novel protein family involved in inflammation". Nat Rev Mol Cell Biol. 4 (2): 95–104. doi:10.1038/nrm1019. PMID 12563287.
  6. ^ Wang L, Manji GA, Grenier JM, Al-Garawi A, Merriam S, Lora JM, Geddes BJ, Briskin M, DiStefano PS, Bertin J (Aug 2002). "PYPAF7, a novel PYRIN-containing Apaf1-like protein that regulates activation of NF-kappa B and caspase-1-dependent cytokine processing". J Biol Chem. 277 (33): 29874–80. doi:10.1074/jbc.M203915200. PMID 12019269.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  7. ^ a b "Entrez Gene: NLRP4 NLR family, pyrin domain containing 4".

Further reading


Stub icon

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by expanding it.

Retrieved from "https://en.wikipedia.org/w/index.php?title=NLRP4&oldid=891433337"