Ethynerone: Difference between revisions
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[[File:Progestin-induced tumors in beagle dogs.png|thumb|left|350px|[[Mammary tumor]]s in [[beagle]] [[dog]]s treated by (left) MK-665 ([[ethynerone]] with [[mestranol]]) and (right) [[chloroethynyl norgestrel]] with mestranol for 4 years at a dosage of 1.05 mg/kg/day cyclically.]]{{Clear}} |
[[File:Progestin-induced tumors in beagle dogs.png|thumb|left|350px|[[Mammary tumor]]s in [[beagle]] [[dog]]s treated by (left) MK-665 ([[ethynerone]] with [[mestranol]]) and (right) [[chloroethynyl norgestrel]] with mestranol for 4 years at a dosage of 1.05 mg/kg/day cyclically.]]{{Clear}} |
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==Synthesis== |
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[[File:Ethynerone synthesis.svg|thumb|left|600px|Ethynerone synthesis.<ref>p165 Lednicer Mitscher book 1 and p146 (2)</ref> J. Fried and T. S. Bry {{US Patent|3096353}} (1963, [[Merck & Co.]] Inc).]]{{Clear}} |
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==See also== |
==See also== |
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Revision as of 19:18, 10 September 2016
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| Clinical data | |
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| Routes of administration | Oral |
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| Chemical and physical data | |
| Formula | C20H23ClO2 |
| Molar mass | 330.84842 g/mol g·mol−1 |
| 3D model (JSmol) | |
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Ethynerone (INN, USAN) is a steroidal progestin of the 19-nortestosterone group that was first reported in 1961 but was never marketed.[1] Under the developmental code name MK-665, it was studied in combination with mestranol as an oral contraceptive.[2] Development of the drug was discontinued due to concerns surrounding toxicity findings in dogs.[2] It is a chloro-ethynyl derivative of norethisterone.[3]
In 1966, during its clinical development, ethynerone was found to produce mammary gland tumors in dogs treated with it at very high doses for prolonged periods of time.[4][5][6] Subsequent investigation found that 17α-hydroxyprogesterone derivatves included anagestone acetate, chlormadinone acetate, medroxyprogesterone acetate, and megestrol acetate produced similar mammary gland tumors, and that their ability to do so correlated directly with their progestogenic actions.[6][7] In contrast, the non-halogenated 19-nortestosterone derivatives norgestrel, norethisterone, noretynodrel, and etynodiol diacetate, which are much less potent as progestogens, did not produce such effects at the dosages tested.[6] Clinical development of ethynerone was discontinued, and many of the 17α-hydroxyprogesterone derivatives were withdrawn for the indication of hormonal contraception.[6][7] Research later on revealed species differences between dogs and humans and established that there is no similar risk in humans.[2]
Synthesis
See also
References
- ^ J. Elks (14 November 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. pp. 521–. ISBN 978-1-4757-2085-3.
- ^ a b c Benno Clemens Runnebaum; Thomas Rabe; Ludwig Kiesel (6 December 2012). Female Contraception: Update and Trends. Springer Science & Business Media. pp. 134–135. ISBN 978-3-642-73790-9.
- ^ Egon Diczfalusy; World Health Organization. Acta Endocrinologica: Supplementum. Ejnar Munksgaard. p. 261.
- ^ Geil, R. G.; Lamar, J. K. (2009). "FDA studies of estrogen, progestogens, and estrogen/progestogen combinations in the dog and monkey". Journal of Toxicology and Environmental Health. 3 (1–2): 179–193. doi:10.1080/15287397709529557. ISSN 0098-4108.
- ^ Jacobs, A. C.; Hatfield, K. P. (2012). "History of Chronic Toxicity and Animal Carcinogenicity Studies for Pharmaceuticals". Veterinary Pathology. 50 (2): 324–333. doi:10.1177/0300985812450727. ISSN 0300-9858.
- ^ a b c d C.H. Lingeman (6 December 2012). Carcinogenic Hormones. Springer Science & Business Media. pp. 149–. ISBN 978-3-642-81267-5.
- ^ a b V. H. T. James; J. R. Pasqualini (22 October 2013). Hormonal Steroids: Proceedings of the Fifth International Congress on Hormonal Steroids. Elsevier Science. pp. 7–8. ISBN 978-1-4831-5895-2.
- ^ p165 Lednicer Mitscher book 1 and p146 (2)
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