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[[Electroencephalography]] (EEG) studies of animals suggest that adapromine and related adamantanes including amantadine, [[bromantane]] (1-amino-2-bromophenyladamantane), and memantine have [[psychostimulant]]-like and possibly [[antidepressant]]-like effects, and that these effects may be mediated via [[catecholaminergic]] processes.<ref name="pmid1458170">{{cite journal | vauthors = Krapivin SV, Sergeeva SA, Morozov IS | title = [A spectral analysis of the effect of adapromine on brain bioelectrical activity] | language = Russian | journal = Eksp Klin Farmakol | volume = 55 | issue = 3 | pages = 6–8 | year = 1992 | pmid = 1458170 | doi = | url = }}</ref><ref name="KrapivinSergeeva1998">{{cite journal|last1=Krapivin|first1=S. V.|last2=Sergeeva|first2=S. A.|last3=Morozov|first3=I. S.|title=Comparative analysis of the effects of adapromine, midantane, and bromantane on bioelectrical activity of rat brain|journal=Bulletin of Experimental Biology and Medicine|volume=125|issue=2|year=1998|pages=151–155|issn=0007-4888|doi=10.1007/BF02496845}}</ref><ref name="pmid7627000">{{cite journal | vauthors = Krapivin SV, Voronina TA | title = [Comparative quantitative pharmacological-EEG analysis of the effects of psychostimulants] | language = Russian | journal = Vestn. Akad. Med. Nauk SSSR | volume = | issue = 6 | pages = 7–16 | year = 1995 | pmid = 7627000 | doi = | url = }}</ref><ref name="KrapivinSergeeva1991">{{cite journal|last1=Krapivin|first1=S. V.|last2=Sergeeva|first2=S. A.|last3=Morozov|first3=I. S.|last4=Dulpe|first4=I. U.|title=Spectral analysis of the effect of midantane on bioelectrical activity of the rat brain|journal=Bulletin of Experimental Biology and Medicine|volume=112|issue=1|year=1991|pages=975–978|issn=0007-4888|doi=10.1007/BF00841147}}</ref> These psychostimulant effects differ qualitatively from those of conventional psychostimulants like [[amphetamine]] however, and the adamantane derivatives have been described contrarily as "[[adaptogen]]s" and as "actoprotectors".<ref name="MorozovIvanova2001">{{cite journal|last1=Morozov|first1=I. S.|last2=Ivanova|first2=I. A.|last3=Lukicheva|first3=T. A.|journal=Pharmaceutical Chemistry Journal|volume=35|issue=5|year=2001|pages=235–238|issn=0091150X|doi=10.1023/A:1011905302667}}</ref>
[[Electroencephalography]] (EEG) studies of animals suggest that adapromine and related adamantanes including amantadine, [[bromantane]] (1-amino-2-bromophenyladamantane), and memantine have [[psychostimulant]]-like and possibly [[antidepressant]]-like effects, and that these effects may be mediated via [[catecholaminergic]] processes.<ref name="pmid1458170">{{cite journal | vauthors = Krapivin SV, Sergeeva SA, Morozov IS | title = [A spectral analysis of the effect of adapromine on brain bioelectrical activity] | language = Russian | journal = Eksp Klin Farmakol | volume = 55 | issue = 3 | pages = 6–8 | year = 1992 | pmid = 1458170 | doi = | url = }}</ref><ref name="KrapivinSergeeva1998">{{cite journal|last1=Krapivin|first1=S. V.|last2=Sergeeva|first2=S. A.|last3=Morozov|first3=I. S.|title=Comparative analysis of the effects of adapromine, midantane, and bromantane on bioelectrical activity of rat brain|journal=Bulletin of Experimental Biology and Medicine|volume=125|issue=2|year=1998|pages=151–155|issn=0007-4888|doi=10.1007/BF02496845}}</ref><ref name="pmid7627000">{{cite journal | vauthors = Krapivin SV, Voronina TA | title = [Comparative quantitative pharmacological-EEG analysis of the effects of psychostimulants] | language = Russian | journal = Vestn. Akad. Med. Nauk SSSR | volume = | issue = 6 | pages = 7–16 | year = 1995 | pmid = 7627000 | doi = | url = }}</ref><ref name="KrapivinSergeeva1991">{{cite journal|last1=Krapivin|first1=S. V.|last2=Sergeeva|first2=S. A.|last3=Morozov|first3=I. S.|last4=Dulpe|first4=I. U.|title=Spectral analysis of the effect of midantane on bioelectrical activity of the rat brain|journal=Bulletin of Experimental Biology and Medicine|volume=112|issue=1|year=1991|pages=975–978|issn=0007-4888|doi=10.1007/BF00841147}}</ref> These psychostimulant effects differ qualitatively from those of conventional psychostimulants like [[amphetamine]] however, and the adamantane derivatives have been described contrarily as "[[adaptogen]]s" and as "actoprotectors".<ref name="MorozovIvanova2001">{{cite journal|last1=Morozov|first1=I. S.|last2=Ivanova|first2=I. A.|last3=Lukicheva|first3=T. A.|journal=Pharmaceutical Chemistry Journal|volume=35|issue=5|year=2001|pages=235–238|issn=0091150X|doi=10.1023/A:1011905302667}}</ref>

==See also==
* [[Tromantadine]]


==References==
==References==

Revision as of 04:31, 13 January 2016

Adapromine
Clinical data
Other namesJP-62, MK-3
Routes of
administration		Oral
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
  • 1-(1-Adamantyl)propan-1-amine
CAS Number
PubChem CID
ChemSpider
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H23N
Molar mass193.32842 g/mol g·mol−1
3D model (JSmol)
  • CCC(C12CC3CC(C1)CC(C3)C2)N

Adapromine, also known as 1-(1-aminopropyl)adamantane, is an antiviral drug of the adamantane group related to amantadine (1-aminoadamantane), rimantadine (1-(1-aminoethyl)adamantane), and memantine (1-amino-3,5-dimethyladamantane) that is marketed in Russia for the treatment and prevention of influenza.[1][2][3][4] It is an alkyl analogue of rimantadine and is similar to rimantadine in its antiviral activity but possesses a broader spectrum of action, being effective against influenza viruses of both type A and B.[1][2][5] Strains of type A influenza virus with resistance to adapromine and rimantadine and the related drug deitiforine (a boron analogue of rimantadine) were encountered in Mongolia and the Soviet Union in the 1980s.[6][7]

Electroencephalography (EEG) studies of animals suggest that adapromine and related adamantanes including amantadine, bromantane (1-amino-2-bromophenyladamantane), and memantine have psychostimulant-like and possibly antidepressant-like effects, and that these effects may be mediated via catecholaminergic processes.[8][9][10][11] These psychostimulant effects differ qualitatively from those of conventional psychostimulants like amphetamine however, and the adamantane derivatives have been described contrarily as "adaptogens" and as "actoprotectors".[12]

See also

References

  1. ^ a b Spasov, A. A.; Khamidova, T. V.; Bugaeva, L. I.; Morozov, I. S. (2000). "Adamantane derivatives: Pharmacological and toxicological properties (review)". Pharmaceutical Chemistry Journal. 34 (1): 1–7. doi:10.1007/BF02524549. ISSN 0091-150X.
  2. ^ a b Lavrova, L. N.; Indulen, M. K.; Ryazantseva, G. M.; Korytnyi, V. S.; Yashunskii, V. G. (1990). "Synthesis and biological activity of some 1-hydroxy-3-aminoalkyladamantanes and their derivatives". Pharmaceutical Chemistry Journal. 24 (1): 35–39. doi:10.1007/BF00769383. ISSN 0091-150X.
  3. ^ Gavrilova, N. A.; Frolenko, T. A.; Semichenko, E. S.; Suboch, G. A. (2010). "Synthesis of naphtho[1,2-d]imidazoles containing an adamantyl fragment". Russian Journal of Organic Chemistry. 46 (5): 777–778. doi:10.1134/S1070428010050349. ISSN 1070-4280.
  4. ^ Rodionov, V. N.; Sklyarova, A. S.; Shamota, T. V.; Schreiner, P. R.; Fokin, A. A. (2011). "Selective reductive dimerization of homocubane series oximes". Russian Journal of Organic Chemistry. 47 (11): 1695–1702. doi:10.1134/S1070428011110078. ISSN 1070-4280.
  5. ^ Leneva, I. A.; Glushkov, R. G.; Gus’kova, T. A. (2004). "Drugs for chemotherapy and prophylaxis of influenza: Mechanisms, efficacy, and safety (a review)". Pharmaceutical Chemistry Journal. 38 (11): 590–596. doi:10.1007/s11094-005-0036-9. ISSN 0091-150X.
  6. ^ Kozeletskaia KN, Grinbaum EB, Zhamsrangiĭn M, Burmistrova VV, Kiselev OI (1990). "[The isolation and study of the properties of current influenza A viruses (H1N1) with a natural resistance to remantadine]". Vopr. Virusol. (in Russian). 35 (4): 289–93. PMID 1701588.
  7. ^ Kozeletskaia KN, Karginov VA, Kiseleva OI, Mishin VP, Grinbaum EB, Burmistrova VV (1995). "[The origin of resistance to chemicals of naturally occurring isolates of influenza A virus]". Vestn. Akad. Med. Nauk SSSR (in Russian) (9): 36–41. PMID 7580412.
  8. ^ Krapivin SV, Sergeeva SA, Morozov IS (1992). "[A spectral analysis of the effect of adapromine on brain bioelectrical activity]". Eksp Klin Farmakol (in Russian). 55 (3): 6–8. PMID 1458170.
  9. ^ Krapivin, S. V.; Sergeeva, S. A.; Morozov, I. S. (1998). "Comparative analysis of the effects of adapromine, midantane, and bromantane on bioelectrical activity of rat brain". Bulletin of Experimental Biology and Medicine. 125 (2): 151–155. doi:10.1007/BF02496845. ISSN 0007-4888.
  10. ^ Krapivin SV, Voronina TA (1995). "[Comparative quantitative pharmacological-EEG analysis of the effects of psychostimulants]". Vestn. Akad. Med. Nauk SSSR (in Russian) (6): 7–16. PMID 7627000.
  11. ^ Krapivin, S. V.; Sergeeva, S. A.; Morozov, I. S.; Dulpe, I. U. (1991). "Spectral analysis of the effect of midantane on bioelectrical activity of the rat brain". Bulletin of Experimental Biology and Medicine. 112 (1): 975–978. doi:10.1007/BF00841147. ISSN 0007-4888.
  12. ^ Morozov, I. S.; Ivanova, I. A.; Lukicheva, T. A. (2001). Pharmaceutical Chemistry Journal. 35 (5): 235–238. doi:10.1023/A:1011905302667. ISSN 0091-150X. {{cite journal}}: Missing or empty |title= (help)



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