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==Interactions==
==Interactions==
MAD2L1 has been shown to [[Protein-protein interaction|interact]] with [[MAD2L2]],<ref name=pmid10660610>{{cite journal |last=Murakumo |first=Y |authorlink= |coauthors=Roth T, Ishii H, Rasio D, Numata S, Croce C M, Fishel R |date=February 2000 |title=A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 |journal=J. Biol. Chem. |volume=275 |issue=6 |pages=4391–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10660610 |doi=10.1074/jbc.275.6.4391 }}</ref> [[CDC20]],<ref name=pmid11438673>{{cite journal |last=Zhang |first=Y |authorlink= |coauthors=Lees E |date=August 2001 |title=Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation |journal=Mol. Cell. Biol. |volume=21 |issue=15 |pages=5190–9 |publisher= |location = United States| issn = 0270-7306| pmid = 11438673 |doi = 10.1128/MCB.21.15.5190-5199.2001 |pmc=87243 }}</ref><ref name=pmid14607335>{{cite journal |last=Sihn |first=Choong-Ryoul |authorlink= |coauthors=Suh Eun-Jung, Lee Kee-Ho, Kim Tae-Yoon, Kim Sang Hoon |date=November 2003 |title=p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells |journal=Cancer Lett. |volume=201 |issue=2 |pages=203–10 |publisher= |location = Ireland| issn = 0304-3835| pmid = 14607335 |doi=10.1016/S0304-3835(03)00465-8 }}</ref><ref name=pmid10700282>{{cite journal |last=Luo |first=X |authorlink= |coauthors=Fang G, Coldiron M, Lin Y, Yu H, Kirschner M W, Wagner G |date=March 2000 |title=Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 |journal=Nat. Struct. Biol. |volume=7 |issue=3 |pages=224–9 |publisher= |location = UNITED STATES| issn = 1072-8368| pmid = 10700282 |doi = 10.1038/73338 }}</ref><ref name=pmid11707408>{{cite journal |last=Sironi |first=L |authorlink= |coauthors=Melixetian M, Faretta M, Prosperini E, Helin K, Musacchio A |date=November 2001 |title=Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint |journal=EMBO J. |volume=20 |issue=22 |pages=6371–82 |publisher= |location = England| issn = 0261-4189| pmid = 11707408 |doi = 10.1093/emboj/20.22.6371 |pmc=125308 }}</ref><ref name=pmid14561775>{{cite journal |last=D'Angiolella |first=Vincenzo |authorlink= |coauthors=Mari Cecilia, Nocera Donatella, Rametti Linda, Grieco Domenico |date=October 2003 |title=The spindle checkpoint requires cyclin-dependent kinase activity |journal=Genes Dev. |volume=17 |issue=20 |pages=2520–5 |publisher= |location = United States| issn = 0890-9369| pmid = 14561775 |doi = 10.1101/gad.267603 |pmc=218146 }}</ref><ref name=pmid12196507>{{cite journal |last=Kallio |first=Marko J |authorlink= |coauthors=Beardmore Victoria A, Weinstein Jasminder, Gorbsky Gary J |date=September 2002 |title=Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells |journal=J. Cell Biol. |volume=158 |issue=5 |pages=841–7 |publisher= |location = United States| issn = 0021-9525| pmid = 12196507 |doi = 10.1083/jcb.200201135 |pmc=2173153 }}</ref><ref name=pmid9736712>{{cite journal |last=Wassmann |first=K |authorlink= |coauthors=Benezra R |date=September 1998 |title=Mad2 transiently associates with an APC/p55Cdc complex during mitosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |issue=19 |pages=11193–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9736712 |doi=10.1073/pnas.95.19.11193 |pmc=21618 }}</ref><ref name=pmid9628895>{{cite journal |last=Kallio |first=M |authorlink= |coauthors=Weinstein J, Daum J R, Burke D J, Gorbsky G J |date=June 1998 |title=Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events |journal=J. Cell Biol. |volume=141 |issue=6 |pages=1393–406 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 9628895 |doi=10.1083/jcb.141.6.1393 |pmc=2132789 }}</ref><ref name=pmid9637688>{{cite journal |last=Fang |first=G |authorlink= |coauthors=Yu H, Kirschner M W |date=June 1998 |title=The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation |journal=Genes Dev. |volume=12 |issue=12 |pages=1871–83 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 9637688 |doi=10.1101/gad.12.12.1871 |pmc=316912 }}</ref><ref name=pmid11274370>{{cite journal |last=Skoufias |first=D A |authorlink= |coauthors=Andreassen P R, Lacroix F B, Wilson L, Margolis R L |date=April 2001 |title=Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=8 |pages=4492–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11274370 |doi = 10.1073/pnas.081076898 |pmc=31862 }}</ref><ref name=pmid18997788>{{cite journal |last=Nilsson |first=Jakob |authorlink= |coauthors=Yekezare Mona, Minshull Jeremy, Pines Jonathon |date=December 2008 |title=The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction |journal=Nat. Cell Biol. |volume=10 |issue=12 |pages=1411–20 |publisher= |location = England| issn = | pmid = 18997788 |doi = 10.1038/ncb1799 |pmc=2635557 }}</ref><ref name=pmid18592005>{{cite journal |last=Privette |first=Lisa M |authorlink= |coauthors=Weier Jingly Fung, Nguyen Ha Nam, Yu Xiaochun, Petty Elizabeth M |date=July 2008 |title=Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint |journal=Neoplasia |volume=10 |issue=7 |pages=643–52 |publisher= |location = Canada| issn = | pmid = 18592005 |pmc=2435002 }}</ref> [[BUB1B]],<ref name=pmid11535616>{{cite journal |last=Sudakin |first=V |authorlink= |coauthors=Chan G K, Yen T J |date=September 2001 |title=Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 |journal=J. Cell Biol. |volume=154 |issue=5 |pages=925–36 |publisher= |location = United States| issn = 0021-9525| pmid = 11535616 |doi = 10.1083/jcb.200102093 |pmc=2196190 }}</ref> [[Estrogen receptor beta]],<ref name=pmid10706629>{{cite journal |last=Poelzl |first=G |authorlink= |coauthors=Kasai Y, Mochizuki N, Shaul P W, Brown M, Mendelsohn M E |date=March 2000 |title=Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=6 |pages=2836–9 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10706629 |doi = 10.1073/pnas.050580997 |pmc=16016 }}</ref> [[ADAM17]],<ref name=pmid10527948>{{cite journal |last=Nelson |first=K K |authorlink= |coauthors=Schlöndorff J, Blobel C P |date=November 1999 |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages=673–80 |publisher= |location = ENGLAND| issn = 0264-6021| pmid = 10527948 |pmc=1220601 |doi=10.1042/0264-6021:3430673}}</ref><ref name=pmid11741929>{{cite journal |last=Poghosyan |first=Zaruhi |authorlink= |coauthors=Robbins Stephen M, Houslay Miles D, Webster Ailsa, Murphy Gillian, Edwards Dylan R |date=February 2002 |title=Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue=7 |pages=4999–5007 |publisher= |location = United States| issn = 0021-9258| pmid = 11741929 |doi = 10.1074/jbc.M107430200 }}</ref> [[Ubiquitin D|UBD]],<ref name=pmid10200259>{{cite journal |last=Liu |first=Y C |authorlink= |coauthors=Pan J, Zhang C, Fan W, Collinge M, Bender J R, Weissman S M |date=April 1999 |title=A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=96 |issue=8 |pages=4313–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10200259 |doi=10.1073/pnas.96.8.4313 |pmc=16329 }}</ref> [[CDC27]]<ref name=pmid9736712/><ref name=pmid9628895/> and [[Mad1]].<ref name=pmid10660610/><ref name=pmid11707408/><ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |date=October 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 }}</ref>
MAD2L1 has been shown to [[Protein-protein interaction|interact]] with [[MAD2L2]],<ref name=pmid10660610>{{cite journal |last=Murakumo |first=Y |authorlink= |author2=Roth T |author3=Ishii H |author4=Rasio D |author5=Numata S |author6=Croce C M |author7=Fishel R |date=February 2000 |title=A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 |journal=J. Biol. Chem. |volume=275 |issue=6 |pages=4391–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10660610 |doi=10.1074/jbc.275.6.4391 }}</ref> [[CDC20]],<ref name=pmid11438673>{{cite journal |last=Zhang |first=Y |authorlink= |author2=Lees E |date=August 2001 |title=Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation |journal=Mol. Cell. Biol. |volume=21 |issue=15 |pages=5190–9 |publisher= |location = United States| issn = 0270-7306| pmid = 11438673 |doi = 10.1128/MCB.21.15.5190-5199.2001 |pmc=87243 }}</ref><ref name=pmid14607335>{{cite journal |last=Sihn |first=Choong-Ryoul |authorlink= |author2=Suh Eun-Jung |author3=Lee Kee-Ho |author4=Kim Tae-Yoon |author5=Kim Sang Hoon |date=November 2003 |title=p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells |journal=Cancer Lett. |volume=201 |issue=2 |pages=203–10 |publisher= |location = Ireland| issn = 0304-3835| pmid = 14607335 |doi=10.1016/S0304-3835(03)00465-8 }}</ref><ref name=pmid10700282>{{cite journal |last=Luo |first=X |authorlink= |author2=Fang G |author3=Coldiron M |author4=Lin Y |author5=Yu H |author6=Kirschner M W |author7=Wagner G |date=March 2000 |title=Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 |journal=Nat. Struct. Biol. |volume=7 |issue=3 |pages=224–9 |publisher= |location = UNITED STATES| issn = 1072-8368| pmid = 10700282 |doi = 10.1038/73338 }}</ref><ref name=pmid11707408>{{cite journal |last=Sironi |first=L |authorlink= |author2=Melixetian M |author3=Faretta M |author4=Prosperini E |author5=Helin K |author6=Musacchio A |date=November 2001 |title=Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint |journal=EMBO J. |volume=20 |issue=22 |pages=6371–82 |publisher= |location = England| issn = 0261-4189| pmid = 11707408 |doi = 10.1093/emboj/20.22.6371 |pmc=125308 }}</ref><ref name=pmid14561775>{{cite journal |last=D'Angiolella |first=Vincenzo |authorlink= |author2=Mari Cecilia |author3=Nocera Donatella |author4=Rametti Linda |author5=Grieco Domenico |date=October 2003 |title=The spindle checkpoint requires cyclin-dependent kinase activity |journal=Genes Dev. |volume=17 |issue=20 |pages=2520–5 |publisher= |location = United States| issn = 0890-9369| pmid = 14561775 |doi = 10.1101/gad.267603 |pmc=218146 }}</ref><ref name=pmid12196507>{{cite journal |last=Kallio |first=Marko J |authorlink= |author2=Beardmore Victoria A |author3=Weinstein Jasminder |author4=Gorbsky Gary J |date=September 2002 |title=Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells |journal=J. Cell Biol. |volume=158 |issue=5 |pages=841–7 |publisher= |location = United States| issn = 0021-9525| pmid = 12196507 |doi = 10.1083/jcb.200201135 |pmc=2173153 }}</ref><ref name=pmid9736712>{{cite journal |last=Wassmann |first=K |authorlink= |author2=Benezra R |date=September 1998 |title=Mad2 transiently associates with an APC/p55Cdc complex during mitosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |issue=19 |pages=11193–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9736712 |doi=10.1073/pnas.95.19.11193 |pmc=21618 }}</ref><ref name=pmid9628895>{{cite journal |last=Kallio |first=M |authorlink= |author2=Weinstein J |author3=Daum J R |author4=Burke D J |author5=Gorbsky G J |date=June 1998 |title=Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events |journal=J. Cell Biol. |volume=141 |issue=6 |pages=1393–406 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 9628895 |doi=10.1083/jcb.141.6.1393 |pmc=2132789 }}</ref><ref name=pmid9637688>{{cite journal |last=Fang |first=G |authorlink= |author2=Yu H |author3=Kirschner M W |date=June 1998 |title=The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation |journal=Genes Dev. |volume=12 |issue=12 |pages=1871–83 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 9637688 |doi=10.1101/gad.12.12.1871 |pmc=316912 }}</ref><ref name=pmid11274370>{{cite journal |last=Skoufias |first=D A |authorlink= |author2=Andreassen P R |author3=Lacroix F B |author4=Wilson L |author5=Margolis R L |date=April 2001 |title=Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=8 |pages=4492–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11274370 |doi = 10.1073/pnas.081076898 |pmc=31862 }}</ref><ref name=pmid18997788>{{cite journal |last=Nilsson |first=Jakob |authorlink= |author2=Yekezare Mona |author3=Minshull Jeremy |author4=Pines Jonathon |date=December 2008 |title=The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction |journal=Nat. Cell Biol. |volume=10 |issue=12 |pages=1411–20 |publisher= |location = England| issn = | pmid = 18997788 |doi = 10.1038/ncb1799 |pmc=2635557 }}</ref><ref name=pmid18592005>{{cite journal |last=Privette |first=Lisa M |authorlink= |author2=Weier Jingly Fung |author3=Nguyen Ha Nam |author4=Yu Xiaochun |author5=Petty Elizabeth M |date=July 2008 |title=Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint |journal=Neoplasia |volume=10 |issue=7 |pages=643–52 |publisher= |location = Canada| issn = | pmid = 18592005 |pmc=2435002 }}</ref> [[BUB1B]],<ref name=pmid11535616>{{cite journal |last=Sudakin |first=V |authorlink= |author2=Chan G K |author3=Yen T J |date=September 2001 |title=Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 |journal=J. Cell Biol. |volume=154 |issue=5 |pages=925–36 |publisher= |location = United States| issn = 0021-9525| pmid = 11535616 |doi = 10.1083/jcb.200102093 |pmc=2196190 }}</ref> [[Estrogen receptor beta]],<ref name=pmid10706629>{{cite journal |last=Poelzl |first=G |authorlink= |author2=Kasai Y |author3=Mochizuki N |author4=Shaul P W |author5=Brown M |author6=Mendelsohn M E |date=March 2000 |title=Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=6 |pages=2836–9 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10706629 |doi = 10.1073/pnas.050580997 |pmc=16016 }}</ref> [[ADAM17]],<ref name=pmid10527948>{{cite journal |last=Nelson |first=K K |authorlink= |author2=Schlöndorff J |author3=Blobel C P |date=November 1999 |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages=673–80 |publisher= |location = ENGLAND| issn = 0264-6021| pmid = 10527948 |pmc=1220601 |doi=10.1042/0264-6021:3430673}}</ref><ref name=pmid11741929>{{cite journal |last=Poghosyan |first=Zaruhi |authorlink= |author2=Robbins Stephen M |author3=Houslay Miles D |author4=Webster Ailsa |author5=Murphy Gillian |author6=Edwards Dylan R |date=February 2002 |title=Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue=7 |pages=4999–5007 |publisher= |location = United States| issn = 0021-9258| pmid = 11741929 |doi = 10.1074/jbc.M107430200 }}</ref> [[Ubiquitin D|UBD]],<ref name=pmid10200259>{{cite journal |last=Liu |first=Y C |authorlink= |author2=Pan J |author3=Zhang C |author4=Fan W |author5=Collinge M |author6=Bender J R |author7=Weissman S M |date=April 1999 |title=A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=96 |issue=8 |pages=4313–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10200259 |doi=10.1073/pnas.96.8.4313 |pmc=16329 }}</ref> [[CDC27]]<ref name=pmid9736712/><ref name=pmid9628895/> and [[Mad1]].<ref name=pmid10660610/><ref name=pmid11707408/><ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |date=October 2005 |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 }}</ref>


==References==
==References==
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*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=O'Neill TJ, Zhu Y, Gustafson TA |title=Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10035–40 |year= 1997 |pmid= 9092546 |doi=10.1074/jbc.272.15.10035 }}
*{{cite journal | author=O'Neill TJ, Zhu Y, Gustafson TA |title=Interaction of MAD2 with the carboxyl terminus of the insulin receptor but not with the IGFIR. Evidence for release from the insulin receptor after activation |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10035–40 |year= 1997 |pmid= 9092546 |doi=10.1074/jbc.272.15.10035 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Jin DY, Spencer F, Jeang KT |title=Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1 |journal=Cell |volume=93 |issue= 1 |pages= 81–91 |year= 1998 |pmid= 9546394 |doi=10.1016/S0092-8674(00)81148-4 }}
*{{cite journal | author=Jin DY, Spencer F, Jeang KT |title=Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1 |journal=Cell |volume=93 |issue= 1 |pages= 81–91 |year= 1998 |pmid= 9546394 |doi=10.1016/S0092-8674(00)81148-4 }}
*{{cite journal | author=Krishnan R, Goodman B, Jin DY, ''et al.'' |title=Map location and gene structure of the Homo sapiens mitotic arrest deficient 2 (MAD2L1) gene at 4q27 |journal=Genomics |volume=49 |issue= 3 |pages= 475–8 |year= 1998 |pmid= 9615237 |doi= 10.1006/geno.1998.5233 }}
*{{cite journal | author=Krishnan R, Goodman B, Jin DY, et al. |title=Map location and gene structure of the Homo sapiens mitotic arrest deficient 2 (MAD2L1) gene at 4q27 |journal=Genomics |volume=49 |issue= 3 |pages= 475–8 |year= 1998 |pmid= 9615237 |doi= 10.1006/geno.1998.5233 }}
*{{cite journal | author=Kallio M, Weinstein J, Daum JR, ''et al.'' |title=Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events |journal=J. Cell Biol. |volume=141 |issue= 6 |pages= 1393–406 |year= 1998 |pmid= 9628895 |doi=10.1083/jcb.141.6.1393 | pmc=2132789 }}
*{{cite journal | author=Kallio M, Weinstein J, Daum JR, et al. |title=Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events |journal=J. Cell Biol. |volume=141 |issue= 6 |pages= 1393–406 |year= 1998 |pmid= 9628895 |doi=10.1083/jcb.141.6.1393 | pmc=2132789 }}
*{{cite journal | author=Fang G, Yu H, Kirschner MW |title=The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation |journal=Genes Dev. |volume=12 |issue= 12 |pages= 1871–83 |year= 1998 |pmid= 9637688 |doi=10.1101/gad.12.12.1871 | pmc=316912 }}
*{{cite journal | author=Fang G, Yu H, Kirschner MW |title=The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation |journal=Genes Dev. |volume=12 |issue= 12 |pages= 1871–83 |year= 1998 |pmid= 9637688 |doi=10.1101/gad.12.12.1871 | pmc=316912 }}
*{{cite journal | author=Wassmann K, Benezra R |title=Mad2 transiently associates with an APC/p55Cdc complex during mitosis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11193–8 |year= 1998 |pmid= 9736712 |doi=10.1073/pnas.95.19.11193 | pmc=21618 }}
*{{cite journal | author=Wassmann K, Benezra R |title=Mad2 transiently associates with an APC/p55Cdc complex during mitosis |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 19 |pages= 11193–8 |year= 1998 |pmid= 9736712 |doi=10.1073/pnas.95.19.11193 | pmc=21618 }}
*{{cite journal | author=Liu YC, Pan J, Zhang C, ''et al.'' |title=A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 8 |pages= 4313–8 |year= 1999 |pmid= 10200259 |doi=10.1073/pnas.96.8.4313 | pmc=16329 }}
*{{cite journal | author=Liu YC, Pan J, Zhang C, et al. |title=A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 8 |pages= 4313–8 |year= 1999 |pmid= 10200259 |doi=10.1073/pnas.96.8.4313 | pmc=16329 }}
*{{cite journal | author=Cahill DP, da Costa LT, Carson-Walter EB, ''et al.'' |title=Characterization of MAD2B and other mitotic spindle checkpoint genes |journal=Genomics |volume=58 |issue= 2 |pages= 181–7 |year= 1999 |pmid= 10366450 |doi= 10.1006/geno.1999.5831 }}
*{{cite journal | author=Cahill DP, da Costa LT, Carson-Walter EB, et al. |title=Characterization of MAD2B and other mitotic spindle checkpoint genes |journal=Genomics |volume=58 |issue= 2 |pages= 181–7 |year= 1999 |pmid= 10366450 |doi= 10.1006/geno.1999.5831 }}
*{{cite journal | author=Nelson KK, Schlöndorff J, Blobel CP |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages= 673–80 |year= 2000 |pmid= 10527948 |doi= 10.1042/0264-6021:3430673| pmc=1220601 }}
*{{cite journal | author=Nelson KK, Schlöndorff J, Blobel CP |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages= 673–80 |year= 2000 |pmid= 10527948 |doi= 10.1042/0264-6021:3430673| pmc=1220601 }}
*{{cite journal | author=Murakumo Y, Roth T, Ishii H, ''et al.'' |title=A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4391–7 |year= 2000 |pmid= 10660610 |doi=10.1074/jbc.275.6.4391 }}
*{{cite journal | author=Murakumo Y, Roth T, Ishii H, et al. |title=A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4391–7 |year= 2000 |pmid= 10660610 |doi=10.1074/jbc.275.6.4391 }}
*{{cite journal | author=Luo X, Fang G, Coldiron M, ''et al.'' |title=Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 |journal=Nat. Struct. Biol. |volume=7 |issue= 3 |pages= 224–9 |year= 2000 |pmid= 10700282 |doi= 10.1038/73338 }}
*{{cite journal | author=Luo X, Fang G, Coldiron M, et al. |title=Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 |journal=Nat. Struct. Biol. |volume=7 |issue= 3 |pages= 224–9 |year= 2000 |pmid= 10700282 |doi= 10.1038/73338 }}
*{{cite journal | author=Poelzl G, Kasai Y, Mochizuki N, ''et al.'' |title=Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2836–9 |year= 2000 |pmid= 10706629 |doi= 10.1073/pnas.050580997 | pmc=16016 }}
*{{cite journal | author=Poelzl G, Kasai Y, Mochizuki N, et al. |title=Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2836–9 |year= 2000 |pmid= 10706629 |doi= 10.1073/pnas.050580997 | pmc=16016 }}
*{{cite journal | author=Steuerwald N, Cohen J, Herrera RJ, ''et al.'' |title=Association between spindle assembly checkpoint expression and maternal age in human oocytes |journal=Mol. Hum. Reprod. |volume=7 |issue= 1 |pages= 49–55 |year= 2001 |pmid= 11134360 |doi=10.1093/molehr/7.1.49 }}
*{{cite journal | author=Steuerwald N, Cohen J, Herrera RJ, et al. |title=Association between spindle assembly checkpoint expression and maternal age in human oocytes |journal=Mol. Hum. Reprod. |volume=7 |issue= 1 |pages= 49–55 |year= 2001 |pmid= 11134360 |doi=10.1093/molehr/7.1.49 }}
*{{cite journal | author=Campbell MS, Chan GK, Yen TJ |title=Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase |journal=J. Cell. Sci. |volume=114 |issue= Pt 5 |pages= 953–63 |year= 2001 |pmid= 11181178 |doi= }}
*{{cite journal | author=Campbell MS, Chan GK, Yen TJ |title=Mitotic checkpoint proteins HsMAD1 and HsMAD2 are associated with nuclear pore complexes in interphase |journal=J. Cell. Sci. |volume=114 |issue= Pt 5 |pages= 953–63 |year= 2001 |pmid= 11181178 |doi= }}
*{{cite journal | author=Zhang Y, Lees E |title=Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5190–9 |year= 2001 |pmid= 11438673 |doi= 10.1128/MCB.21.15.5190-5199.2001 | pmc=87243 }}
*{{cite journal | author=Zhang Y, Lees E |title=Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation |journal=Mol. Cell. Biol. |volume=21 |issue= 15 |pages= 5190–9 |year= 2001 |pmid= 11438673 |doi= 10.1128/MCB.21.15.5190-5199.2001 | pmc=87243 }}

Revision as of 19:57, 12 July 2014

Template:PBB Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.[1][2][3]

Template:PBB Summary

Interactions

MAD2L1 has been shown to interact with MAD2L2,[4] CDC20,[5][6][7][8][9][10][11][12][13][14][15][16] BUB1B,[17] Estrogen receptor beta,[18] ADAM17,[19][20] UBD,[21] CDC27[11][12] and Mad1.[4][8][22]

References

  1. ^ Li Y, Benezra R (October 1996). "Identification of a human mitotic checkpoint gene: hsMAD2". Science. 274 (5285): 246–8. doi:10.1126/science.274.5285.246. PMID 8824189.
  2. ^ Xu L, Deng HX, Yang Y, Xia JH, Hung WY, Siddque T (November 1997). "Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization". Cytogenet Cell Genet. 78 (1): 63–4. doi:10.1159/000134631. PMID 9345911.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)".
  4. ^ a b Murakumo, Y; Roth T; Ishii H; Rasio D; Numata S; Croce C M; Fishel R (February 2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6). UNITED STATES: 4391–7. doi:10.1074/jbc.275.6.4391. ISSN 0021-9258. PMID 10660610.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  5. ^ Zhang, Y; Lees E (August 2001). "Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation". Mol. Cell. Biol. 21 (15). United States: 5190–9. doi:10.1128/MCB.21.15.5190-5199.2001. ISSN 0270-7306. PMC 87243. PMID 11438673.
  6. ^ Sihn, Choong-Ryoul; Suh Eun-Jung; Lee Kee-Ho; Kim Tae-Yoon; Kim Sang Hoon (November 2003). "p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells". Cancer Lett. 201 (2). Ireland: 203–10. doi:10.1016/S0304-3835(03)00465-8. ISSN 0304-3835. PMID 14607335.
  7. ^ Luo, X; Fang G; Coldiron M; Lin Y; Yu H; Kirschner M W; Wagner G (March 2000). "Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20". Nat. Struct. Biol. 7 (3). UNITED STATES: 224–9. doi:10.1038/73338. ISSN 1072-8368. PMID 10700282.
  8. ^ a b Sironi, L; Melixetian M; Faretta M; Prosperini E; Helin K; Musacchio A (November 2001). "Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". EMBO J. 20 (22). England: 6371–82. doi:10.1093/emboj/20.22.6371. ISSN 0261-4189. PMC 125308. PMID 11707408.
  9. ^ D'Angiolella, Vincenzo; Mari Cecilia; Nocera Donatella; Rametti Linda; Grieco Domenico (October 2003). "The spindle checkpoint requires cyclin-dependent kinase activity". Genes Dev. 17 (20). United States: 2520–5. doi:10.1101/gad.267603. ISSN 0890-9369. PMC 218146. PMID 14561775.
  10. ^ Kallio, Marko J; Beardmore Victoria A; Weinstein Jasminder; Gorbsky Gary J (September 2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. 158 (5). United States: 841–7. doi:10.1083/jcb.200201135. ISSN 0021-9525. PMC 2173153. PMID 12196507.
  11. ^ a b Wassmann, K; Benezra R (September 1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis". Proc. Natl. Acad. Sci. U.S.A. 95 (19). UNITED STATES: 11193–8. doi:10.1073/pnas.95.19.11193. ISSN 0027-8424. PMC 21618. PMID 9736712.
  12. ^ a b Kallio, M; Weinstein J; Daum J R; Burke D J; Gorbsky G J (June 1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". J. Cell Biol. 141 (6). UNITED STATES: 1393–406. doi:10.1083/jcb.141.6.1393. ISSN 0021-9525. PMC 2132789. PMID 9628895.
  13. ^ Fang, G; Yu H; Kirschner M W (June 1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation". Genes Dev. 12 (12). UNITED STATES: 1871–83. doi:10.1101/gad.12.12.1871. ISSN 0890-9369. PMC 316912. PMID 9637688.
  14. ^ Skoufias, D A; Andreassen P R; Lacroix F B; Wilson L; Margolis R L (April 2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints". Proc. Natl. Acad. Sci. U.S.A. 98 (8). United States: 4492–7. doi:10.1073/pnas.081076898. ISSN 0027-8424. PMC 31862. PMID 11274370.
  15. ^ Nilsson, Jakob; Yekezare Mona; Minshull Jeremy; Pines Jonathon (December 2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12). England: 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788.
  16. ^ Privette, Lisa M; Weier Jingly Fung; Nguyen Ha Nam; Yu Xiaochun; Petty Elizabeth M (July 2008). "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint". Neoplasia. 10 (7). Canada: 643–52. PMC 2435002. PMID 18592005.
  17. ^ Sudakin, V; Chan G K; Yen T J (September 2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. 154 (5). United States: 925–36. doi:10.1083/jcb.200102093. ISSN 0021-9525. PMC 2196190. PMID 11535616.
  18. ^ Poelzl, G; Kasai Y; Mochizuki N; Shaul P W; Brown M; Mendelsohn M E (March 2000). "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad. Sci. U.S.A. 97 (6). UNITED STATES: 2836–9. doi:10.1073/pnas.050580997. ISSN 0027-8424. PMC 16016. PMID 10706629.
  19. ^ Nelson, K K; Schlöndorff J; Blobel C P (November 1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 Pt 3. ENGLAND: 673–80. doi:10.1042/0264-6021:3430673. ISSN 0264-6021. PMC 1220601. PMID 10527948.
  20. ^ Poghosyan, Zaruhi; Robbins Stephen M; Houslay Miles D; Webster Ailsa; Murphy Gillian; Edwards Dylan R (February 2002). "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases". J. Biol. Chem. 277 (7). United States: 4999–5007. doi:10.1074/jbc.M107430200. ISSN 0021-9258. PMID 11741929.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  21. ^ Liu, Y C; Pan J; Zhang C; Fan W; Collinge M; Bender J R; Weissman S M (April 1999). "A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2". Proc. Natl. Acad. Sci. U.S.A. 96 (8). UNITED STATES: 4313–8. doi:10.1073/pnas.96.8.4313. ISSN 0027-8424. PMC 16329. PMID 10200259.
  22. ^ Rual, Jean-François (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)

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