Jump to content

ASK1: Difference between revisions

From Wikipedia, the free encyclopedia
Browse history interactively
← Previous editNext edit →
Content deleted Content added
VisualWikitext
Line 6: Line 6:
== Mechanism of activation ==
== Mechanism of activation ==


Under nonstress conditions ASK1 is oligomerized (a requirement for its activation) through its C-terminal [[Coiled coil|coiled-coil]] domain (CCC), but remains in an inactive form by the suppressive effect of reduced thioredoxin (Trx) and calcium and integrin binding protein 1 (CIB1).<ref name="pmid19805025">{{cite journal |author=Yoon KW, Cho JH, Lee JK, ''et al.'' |title=CIB1 functions as a Ca2+-sensitive modulator of stress-induced signaling by targeting ASK1 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=106 |issue=41 |pages=17389–94 |year=2009 |month=October |pmid=19805025 |pmc=2762684 |doi=10.1073/pnas.0812259106 |url=}}</ref> Trx inhibits ASK1 kinase activity by direct binding to its N-terminal coiled-coil domain (NCC). Trx and CIB1 regulate ASK1 activation in a redox- or calcium- sensitive manner, respectively. Both appear to compete with TNF-α receptor-associated factor 2 (TRAF2), an ASK1 activator. TRAF2 and TRAF6 are then recruited to ASK1 to form a larger molecular mass complex.<ref name="pmid16129676">{{cite journal |author=Noguchi T, Takeda K, Matsuzawa A, ''et al.'' |title=Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death |journal=J. Biol. Chem. |volume=280 |issue=44 |pages=37033–40 |year=2005 |month=November |pmid=16129676 |doi=10.1074/jbc.M506771200 |url=}}</ref> Subsequently, ASK1 forms homo-oligomeric interactions not only through the CCC, but also the NCC, which leads to full activation of ASK1 through autophosphorylation at threonine 845.<ref name="pmid17724081">{{cite journal |author=Fujino G, Noguchi T, Matsuzawa A, ''et al.'' |title=Thioredoxin and TRAF Family Proteins Regulate Reactive Oxygen Species-Dependent Activation of ASK1 through Reciprocal Modulation of the N-Terminal Homophilic Interaction of ASK1 |journal=Mol. Cell. Biol. |volume=27 |issue=23 |pages=8152–63 |year=2007 |month=December |pmid=17724081 |pmc=2169188 |doi=10.1128/MCB.00227-07 |url=}}</ref>
Under nonstress conditions ASK1 is oligomerized (a requirement for its activation) through its C-terminal [[Coiled coil|coiled-coil]] domain (CCC), but remains in an inactive form by the suppressive effect of reduced thioredoxin ([[Thioredoxin|Trx]]) and calcium and integrin binding protein 1 ([[CIB1|CIB1]]).<ref name="pmid19805025">{{cite journal |author=Yoon KW, Cho JH, Lee JK, ''et al.'' |title=CIB1 functions as a Ca2+-sensitive modulator of stress-induced signaling by targeting ASK1 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=106 |issue=41 |pages=17389–94 |year=2009 |month=October |pmid=19805025 |pmc=2762684 |doi=10.1073/pnas.0812259106 |url=}}</ref> Trx inhibits ASK1 kinase activity by direct binding to its N-terminal coiled-coil domain (NCC). Trx and CIB1 regulate ASK1 activation in a redox- or calcium- sensitive manner, respectively. Both appear to compete with TNF-α receptor-associated factor 2 (TRAF2), an ASK1 activator. TRAF2 and TRAF6 are then recruited to ASK1 to form a larger molecular mass complex.<ref name="pmid16129676">{{cite journal |author=Noguchi T, Takeda K, Matsuzawa A, ''et al.'' |title=Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death |journal=J. Biol. Chem. |volume=280 |issue=44 |pages=37033–40 |year=2005 |month=November |pmid=16129676 |doi=10.1074/jbc.M506771200 |url=}}</ref> Subsequently, ASK1 forms homo-oligomeric interactions not only through the CCC, but also the NCC, which leads to full activation of ASK1 through autophosphorylation at threonine 845.<ref name="pmid17724081">{{cite journal |author=Fujino G, Noguchi T, Matsuzawa A, ''et al.'' |title=Thioredoxin and TRAF Family Proteins Regulate Reactive Oxygen Species-Dependent Activation of ASK1 through Reciprocal Modulation of the N-Terminal Homophilic Interaction of ASK1 |journal=Mol. Cell. Biol. |volume=27 |issue=23 |pages=8152–63 |year=2007 |month=December |pmid=17724081 |pmc=2169188 |doi=10.1128/MCB.00227-07 |url=}}</ref>


==Interactions==
==Interactions==

Revision as of 12:57, 2 November 2011

Template:PBB Apoptosis signal-regulating kinase 1 (ASK1) also known as mitogen-activated protein kinase kinase kinase 5 (MAP3K5) is a member of MAP kinase kinase kinase family and as such a part of mitogen-activated protein kinase pathway. It activates c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinases in a Raf-independent fashion in response to an array of stresses such as oxidative stress, endoplasmic reticulum stress and calcium influx. ASK1 has been found to be involved in cancer, diabetes, cardiovascular and neurodegenerative diseases.[1]

MAP3K5 gene coding for the protein is located on chromosome 6 at locus 6q22.33.[2] and the transcribed protein contains 1,374 amino acids with 11 kinase subdomains.[citation needed] Northern blot analysis shows that MAP3K5 transcript is abundant in human heart and pancreas.[3]

Mechanism of activation

Under nonstress conditions ASK1 is oligomerized (a requirement for its activation) through its C-terminal coiled-coil domain (CCC), but remains in an inactive form by the suppressive effect of reduced thioredoxin (Trx) and calcium and integrin binding protein 1 (CIB1).[4] Trx inhibits ASK1 kinase activity by direct binding to its N-terminal coiled-coil domain (NCC). Trx and CIB1 regulate ASK1 activation in a redox- or calcium- sensitive manner, respectively. Both appear to compete with TNF-α receptor-associated factor 2 (TRAF2), an ASK1 activator. TRAF2 and TRAF6 are then recruited to ASK1 to form a larger molecular mass complex.[5] Subsequently, ASK1 forms homo-oligomeric interactions not only through the CCC, but also the NCC, which leads to full activation of ASK1 through autophosphorylation at threonine 845.[6]

Interactions

ASK1 has been shown to interact with PP5[7] GADD45B,[8] Protein kinase R,[9] CDC25A,[10] Death associated protein 6,[11] RB1CC1,[12] HSPA1A,[13] C-Raf,[14] PDCD6,[15] TRAF2,[16][12] PPP5C,[7] MAPK8IP3,[17] TRAF6,[16][18][19] MAP2K6,[20][7] TRAF5,[16][18] MAP3K7[19] and DUSP19.[21]

References

  1. ^ Hattori K, Naguro I, Runchel C, Ichijo H (2009). "The roles of ASK family proteins in stress responses and diseases". Cell Commun. Signal. 7: 9. doi:10.1186/1478-811X-7-9. PMC 2685135. PMID 19389260.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  2. ^ Rampoldi L, Zimbello R, Bortoluzzi S, Tiso N, Valle G, Lanfranchi G, Danieli GA (1997). "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5". Cytogenet. Cell Genet. 78 (3–4): 301–3. doi:10.1159/000134677. PMID 9465908.{{cite journal}}: CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: MAP3K5 mitogen-activated protein kinase kinase kinase 5".
  4. ^ Yoon KW, Cho JH, Lee JK; et al. (2009). "CIB1 functions as a Ca2+-sensitive modulator of stress-induced signaling by targeting ASK1". Proc. Natl. Acad. Sci. U.S.A. 106 (41): 17389–94. doi:10.1073/pnas.0812259106. PMC 2762684. PMID 19805025. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  5. ^ Noguchi T, Takeda K, Matsuzawa A; et al. (2005). "Recruitment of tumor necrosis factor receptor-associated factor family proteins to apoptosis signal-regulating kinase 1 signalosome is essential for oxidative stress-induced cell death". J. Biol. Chem. 280 (44): 37033–40. doi:10.1074/jbc.M506771200. PMID 16129676. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  6. ^ Fujino G, Noguchi T, Matsuzawa A; et al. (2007). "Thioredoxin and TRAF Family Proteins Regulate Reactive Oxygen Species-Dependent Activation of ASK1 through Reciprocal Modulation of the N-Terminal Homophilic Interaction of ASK1". Mol. Cell. Biol. 27 (23): 8152–63. doi:10.1128/MCB.00227-07. PMC 2169188. PMID 17724081. {{cite journal}}: Explicit use of et al. in: |author= (help); Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  7. ^ a b c Morita, K (2001). "Negative feedback regulation of ASK1 by protein phosphatase 5 (PP5) in response to oxidative stress". EMBO J. 20 (21). England: 6028–36. doi:10.1093/emboj/20.21.6028. ISSN 0261-4189. PMC 125685. PMID 11689443. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); no-break space character in |title= at position 37 (help)CS1 maint: year (link)
  8. ^ Papa, Salvatore (2004). "Gadd45 beta mediates the NF-kappa B suppression of JNK signalling by targeting MKK7/JNKK2". Nat. Cell Biol. 6 (2). England: 146–53. doi:10.1038/ncb1093. ISSN 1465-7392. PMID 14743220. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  9. ^ Takizawa, Takenori (2002). "Double-stranded RNA-activated protein kinase interacts with apoptosis signal-regulating kinase 1. Implications for apoptosis signaling pathways". Eur. J. Biochem. 269 (24). Germany: 6126–32. doi:10.1046/j.1432-1033.2002.03325.x. ISSN 0014-2956. PMID 12473108. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  10. ^ Zou, X (2001). "The Cell Cycle-Regulatory CDC25A Phosphatase Inhibits Apoptosis Signal-Regulating Kinase 1". Mol. Cell. Biol. 21 (14). United States: 4818–28. doi:10.1128/MCB.21.14.4818-4828.2001. ISSN 0270-7306. PMC 87174. PMID 11416155. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  11. ^ Chang, H Y (1998). "Activation of apoptosis signal-regulating kinase 1 (ASK1) by the adapter protein Daxx". Science. 281 (5384). UNITED STATES: 1860–3. doi:10.1126/science.281.5384.1860. ISSN 0036-8075. PMID 9743501. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  12. ^ a b Gan, Boyi (2006). "Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC–mTOR signaling pathways". J. Cell Biol. 175 (1). United States: 121–33. doi:10.1083/jcb.200604129. ISSN 0021-9525. PMC 2064504. PMID 17015619. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  13. ^ Park, Hee-Sae (2002). "Heat Shock Protein Hsp72 Is a Negative Regulator of Apoptosis Signal-Regulating Kinase 1". Mol. Cell. Biol. 22 (22). United States: 7721–30. doi:10.1128/MCB.22.22.7721-7730.2002. ISSN 0270-7306. PMC 134722. PMID 12391142. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  14. ^ Chen, J (2001). "Raf-1 promotes cell survival by antagonizing apoptosis signal-regulating kinase 1 through a MEK–ERK independent mechanism". Proc. Natl. Acad. Sci. U.S.A. 98 (14). United States: 7783–8. doi:10.1073/pnas.141224398. ISSN 0027-8424. PMC 35419. PMID 11427728. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  15. ^ Hwang, In-Sik (2002). "Interaction of ALG-2 with ASK1 influences ASK1 localization and subsequent JNK activation". FEBS Lett. 529 (2–3). Netherlands: 183–7. doi:10.1016/S0014-5793(02)03329-X. ISSN 0014-5793. PMID 12372597. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  16. ^ a b c Nishitoh, H (1998). "ASK1 is essential for JNK/SAPK activation by TRAF2". Mol. Cell. 2 (3). UNITED STATES: 389–95. doi:10.1016/S1097-2765(00)80283-X. ISSN 1097-2765. PMID 9774977. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  17. ^ Matsuura, Hiroshi (2002). "Phosphorylation-dependent scaffolding role of JSAP1/JIP3 in the ASK1-JNK signaling pathway. A new mode of regulation of the MAP kinase cascade". J. Biol. Chem. 277 (43). United States: 40703–9. doi:10.1074/jbc.M202004200. ISSN 0021-9258. PMID 12189133. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  18. ^ a b Hoeflich, K P (1999). "Mediation of TNF receptor-associated factor effector functions by apoptosis signal-regulating kinase-1 (ASK1)". Oncogene. 18 (42). ENGLAND: 5814–20. doi:10.1038/sj.onc.1202975. ISSN 0950-9232. PMID 10523862. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  19. ^ a b Mochida, Y (2000). "ASK1 inhibits interleukin-1-induced NF-kappa B activity through disruption of TRAF6-TAK1 interaction". J. Biol. Chem. 275 (42). UNITED STATES: 32747–52. doi:10.1074/jbc.M003042200. ISSN 0021-9258. PMID 10921914. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  20. ^ Huang, Shile (2003). "Sustained activation of the JNK cascade and rapamycin-induced apoptosis are suppressed by p53/p21(Cip1)". Mol. Cell. 11 (6). United States: 1491–501. doi:10.1016/S1097-2765(03)00180-1. ISSN 1097-2765. PMID 12820963. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  21. ^ Zama, Takeru (2002). "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway". J. Biol. Chem. 277 (26). United States: 23919–26. doi:10.1074/jbc.M200838200. ISSN 0021-9258. PMID 11959862. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)

Further reading

Template:PBB Further reading

Template:PBB Controls

Retrieved from "https://en.wikipedia.org/w/index.php?title=ASK1&oldid=458629354"