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==Interactions==
==Interactions==
MAD2L1 has been shown to [[Protein-protein_interaction|interact]] with [[MAD2L2]],<ref name=pmid10660610>{{cite journal |last=Murakumo |first=Y |authorlink= |coauthors=Roth T, Ishii H, Rasio D, Numata S, Croce C M, Fishel R |year=[[2000]]|month=Feb. |title=A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 |journal=J. Biol. Chem. |volume=275 |issue=6 |pages=4391–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10660610 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.275.6.4391 }}</ref> [[CDC20]],<ref name=pmid11438673>{{cite journal |last=Zhang |first=Y |authorlink= |coauthors=Lees E |year=[[2001]]|month=Aug. |title=Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation |journal=Mol. Cell. Biol. |volume=21 |issue=15 |pages=5190–9 |publisher= |location = United States| issn = 0270-7306| pmid = 11438673 |doi = 10.1128/MCB.21.15.5190-5199.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=87243 }}</ref><ref name=pmid14607335>{{cite journal |last=Sihn |first=Choong-Ryoul |authorlink= |coauthors=Suh Eun-Jung, Lee Kee-Ho, Kim Tae-Yoon, Kim Sang Hoon |year=[[2003]]|month=Nov. |title=p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells |journal=Cancer Lett. |volume=201 |issue=2 |pages=203–10 |publisher= |location = Ireland| issn = 0304-3835| pmid = 14607335 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0304-3835(03)00465-8 }}</ref><ref name=pmid10700282>{{cite journal |last=Luo |first=X |authorlink= |coauthors=Fang G, Coldiron M, Lin Y, Yu H, Kirschner M W, Wagner G |year=[[2000]]|month=Mar. |title=Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 |journal=Nat. Struct. Biol. |volume=7 |issue=3 |pages=224–9 |publisher= |location = UNITED STATES| issn = 1072-8368| pmid = 10700282 |doi = 10.1038/73338 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11707408>{{cite journal |last=Sironi |first=L |authorlink= |coauthors=Melixetian M, Faretta M, Prosperini E, Helin K, Musacchio A |year=[[2001]]|month=Nov. |title=Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint |journal=EMBO J. |volume=20 |issue=22 |pages=6371–82 |publisher= |location = England| issn = 0261-4189| pmid = 11707408 |doi = 10.1093/emboj/20.22.6371 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125308 }}</ref><ref name=pmid14561775>{{cite journal |last=D'Angiolella |first=Vincenzo |authorlink= |coauthors=Mari Cecilia, Nocera Donatella, Rametti Linda, Grieco Domenico |year=[[2003]]|month=Oct. |title=The spindle checkpoint requires cyclin-dependent kinase activity |journal=Genes Dev. |volume=17 |issue=20 |pages=2520–5 |publisher= |location = United States| issn = 0890-9369| pmid = 14561775 |doi = 10.1101/gad.267603 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=218146 }}</ref><ref name=pmid12196507>{{cite journal |last=Kallio |first=Marko J |authorlink= |coauthors=Beardmore Victoria A, Weinstein Jasminder, Gorbsky Gary J |year=[[2002]]|month=Sep. |title=Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells |journal=J. Cell Biol. |volume=158 |issue=5 |pages=841–7 |publisher= |location = United States| issn = 0021-9525| pmid = 12196507 |doi = 10.1083/jcb.200201135 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2173153 }}</ref><ref name=pmid9736712>{{cite journal |last=Wassmann |first=K |authorlink= |coauthors=Benezra R |year=[[1998]]|month=Sep. |title=Mad2 transiently associates with an APC/p55Cdc complex during mitosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |issue=19 |pages=11193–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9736712 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.95.19.11193 |pmc=21618 }}</ref><ref name=pmid9628895>{{cite journal |last=Kallio |first=M |authorlink= |coauthors=Weinstein J, Daum J R, Burke D J, Gorbsky G J |year=[[1998]]|month=Jun. |title=Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events |journal=J. Cell Biol. |volume=141 |issue=6 |pages=1393–406 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 9628895 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1083/jcb.141.6.1393 |pmc=2132789 }}</ref><ref name=pmid9637688>{{cite journal |last=Fang |first=G |authorlink= |coauthors=Yu H, Kirschner M W |year=[[1998]]|month=Jun. |title=The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation |journal=Genes Dev. |volume=12 |issue=12 |pages=1871–83 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 9637688 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1101/gad.12.12.1871 |pmc=316912 }}</ref><ref name=pmid11274370>{{cite journal |last=Skoufias |first=D A |authorlink= |coauthors=Andreassen P R, Lacroix F B, Wilson L, Margolis R L |year=[[2001]]|month=Apr. |title=Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=8 |pages=4492–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11274370 |doi = 10.1073/pnas.081076898 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=31862 }}</ref><ref name=pmid18997788>{{cite journal |unused_data=DUPLICATE DATA: pmid = 19043431 |last=Nilsson |first=Jakob |authorlink= |coauthors=Yekezare Mona, Minshull Jeremy, Pines Jonathon |year=[[2008]]|month=Dec. |title=The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction |journal=Nat. Cell Biol. |volume=10 |issue=12 |pages=1411–20 |publisher= |location = England| issn = | pmid = 18997788 |doi = 10.1038/ncb1799 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2635557 }}</ref><ref name=pmid18592005>{{cite journal |last=Privette |first=Lisa M |authorlink= |coauthors=Weier Jingly Fung, Nguyen Ha Nam, Yu Xiaochun, Petty Elizabeth M |year=[[2008]]|month=Jul. |title=Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint |journal=Neoplasia |volume=10 |issue=7 |pages=643–52 |publisher= |location = Canada| issn = | pmid = 18592005 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2435002 }}</ref> [[BUB1B]],<ref name=pmid11535616>{{cite journal |unused_data=DUPLICATE DATA: pmid = 11535614 |last=Sudakin |first=V |authorlink= |coauthors=Chan G K, Yen T J |year=[[2001]]|month=Sep. |title=Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 |journal=J. Cell Biol. |volume=154 |issue=5 |pages=925–36 |publisher= |location = United States| issn = 0021-9525| pmid = 11535616 |doi = 10.1083/jcb.200102093 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2196190 }}</ref> [[Estrogen receptor beta]],<ref name=pmid10706629>{{cite journal |last=Poelzl |first=G |authorlink= |coauthors=Kasai Y, Mochizuki N, Shaul P W, Brown M, Mendelsohn M E |year=[[2000]]|month=Mar. |title=Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=6 |pages=2836–9 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10706629 |doi = 10.1073/pnas.050580997 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16016 }}</ref> [[ADAM17]],<ref name=pmid10527948>{{cite journal |last=Nelson |first=K K |authorlink= |coauthors=Schlöndorff J, Blobel C P |year=[[1999]]|month=Nov. |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages=673–80 |publisher= |location = ENGLAND| issn = 0264-6021| pmid = 10527948 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1220601 }}</ref><ref name=pmid11741929>{{cite journal |last=Poghosyan |first=Zaruhi |authorlink= |coauthors=Robbins Stephen M, Houslay Miles D, Webster Ailsa, Murphy Gillian, Edwards Dylan R |year=[[2002]]|month=Feb. |title=Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue=7 |pages=4999–5007 |publisher= |location = United States| issn = 0021-9258| pmid = 11741929 |doi = 10.1074/jbc.M107430200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[UBD (gene)|UBD]],<ref name=pmid10200259>{{cite journal |last=Liu |first=Y C |authorlink= |coauthors=Pan J, Zhang C, Fan W, Collinge M, Bender J R, Weissman S M |year=[[1999]]|month=Apr. |title=A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=96 |issue=8 |pages=4313–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10200259 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.96.8.4313 |pmc=16329 }}</ref> [[CDC27]]<ref name=pmid9736712/><ref name=pmid9628895/> and [[Mad1]].<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |year=[[2005]]|month=Oct. |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11707408/><ref name=pmid10660610/>
MAD2L1 has been shown to [[Protein-protein_interaction|interact]] with [[MAD2L2]],<ref name=pmid10660610>{{cite journal |last=Murakumo |first=Y |authorlink= |coauthors=Roth T, Ishii H, Rasio D, Numata S, Croce C M, Fishel R |year=[[2000]]|month=Feb. |title=A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2 |journal=J. Biol. Chem. |volume=275 |issue=6 |pages=4391–7 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 10660610 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.275.6.4391 }}</ref> [[CDC20]],<ref name=pmid11438673>{{cite journal |last=Zhang |first=Y |authorlink= |coauthors=Lees E |year=[[2001]]|month=Aug. |title=Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation |journal=Mol. Cell. Biol. |volume=21 |issue=15 |pages=5190–9 |publisher= |location = United States| issn = 0270-7306| pmid = 11438673 |doi = 10.1128/MCB.21.15.5190-5199.2001 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=87243 }}</ref><ref name=pmid14607335>{{cite journal |last=Sihn |first=Choong-Ryoul |authorlink= |coauthors=Suh Eun-Jung, Lee Kee-Ho, Kim Tae-Yoon, Kim Sang Hoon |year=[[2003]]|month=Nov. |title=p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells |journal=Cancer Lett. |volume=201 |issue=2 |pages=203–10 |publisher= |location = Ireland| issn = 0304-3835| pmid = 14607335 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0304-3835(03)00465-8 }}</ref><ref name=pmid10700282>{{cite journal |last=Luo |first=X |authorlink= |coauthors=Fang G, Coldiron M, Lin Y, Yu H, Kirschner M W, Wagner G |year=[[2000]]|month=Mar. |title=Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20 |journal=Nat. Struct. Biol. |volume=7 |issue=3 |pages=224–9 |publisher= |location = UNITED STATES| issn = 1072-8368| pmid = 10700282 |doi = 10.1038/73338 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11707408>{{cite journal |last=Sironi |first=L |authorlink= |coauthors=Melixetian M, Faretta M, Prosperini E, Helin K, Musacchio A |year=[[2001]]|month=Nov. |title=Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint |journal=EMBO J. |volume=20 |issue=22 |pages=6371–82 |publisher= |location = England| issn = 0261-4189| pmid = 11707408 |doi = 10.1093/emboj/20.22.6371 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125308 }}</ref><ref name=pmid14561775>{{cite journal |last=D'Angiolella |first=Vincenzo |authorlink= |coauthors=Mari Cecilia, Nocera Donatella, Rametti Linda, Grieco Domenico |year=[[2003]]|month=Oct. |title=The spindle checkpoint requires cyclin-dependent kinase activity |journal=Genes Dev. |volume=17 |issue=20 |pages=2520–5 |publisher= |location = United States| issn = 0890-9369| pmid = 14561775 |doi = 10.1101/gad.267603 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=218146 }}</ref><ref name=pmid12196507>{{cite journal |last=Kallio |first=Marko J |authorlink= |coauthors=Beardmore Victoria A, Weinstein Jasminder, Gorbsky Gary J |year=[[2002]]|month=Sep. |title=Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells |journal=J. Cell Biol. |volume=158 |issue=5 |pages=841–7 |publisher= |location = United States| issn = 0021-9525| pmid = 12196507 |doi = 10.1083/jcb.200201135 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2173153 }}</ref><ref name=pmid9736712>{{cite journal |last=Wassmann |first=K |authorlink= |coauthors=Benezra R |year=[[1998]]|month=Sep. |title=Mad2 transiently associates with an APC/p55Cdc complex during mitosis |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=95 |issue=19 |pages=11193–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 9736712 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.95.19.11193 |pmc=21618 }}</ref><ref name=pmid9628895>{{cite journal |last=Kallio |first=M |authorlink= |coauthors=Weinstein J, Daum J R, Burke D J, Gorbsky G J |year=[[1998]]|month=Jun. |title=Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events |journal=J. Cell Biol. |volume=141 |issue=6 |pages=1393–406 |publisher= |location = UNITED STATES| issn = 0021-9525| pmid = 9628895 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1083/jcb.141.6.1393 |pmc=2132789 }}</ref><ref name=pmid9637688>{{cite journal |last=Fang |first=G |authorlink= |coauthors=Yu H, Kirschner M W |year=[[1998]]|month=Jun. |title=The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation |journal=Genes Dev. |volume=12 |issue=12 |pages=1871–83 |publisher= |location = UNITED STATES| issn = 0890-9369| pmid = 9637688 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1101/gad.12.12.1871 |pmc=316912 }}</ref><ref name=pmid11274370>{{cite journal |last=Skoufias |first=D A |authorlink= |coauthors=Andreassen P R, Lacroix F B, Wilson L, Margolis R L |year=[[2001]]|month=Apr. |title=Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=98 |issue=8 |pages=4492–7 |publisher= |location = United States| issn = 0027-8424| pmid = 11274370 |doi = 10.1073/pnas.081076898 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=31862 }}</ref><ref name=pmid18997788>{{cite journal |unused_data=DUPLICATE DATA: pmid = 19043431 |last=Nilsson |first=Jakob |authorlink= |coauthors=Yekezare Mona, Minshull Jeremy, Pines Jonathon |year=[[2008]]|month=Dec. |title=The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction |journal=Nat. Cell Biol. |volume=10 |issue=12 |pages=1411–20 |publisher= |location = England| issn = | pmid = 18997788 |doi = 10.1038/ncb1799 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2635557 }}</ref><ref name=pmid18592005>{{cite journal |last=Privette |first=Lisa M |authorlink= |coauthors=Weier Jingly Fung, Nguyen Ha Nam, Yu Xiaochun, Petty Elizabeth M |year=[[2008]]|month=Jul. |title=Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint |journal=Neoplasia |volume=10 |issue=7 |pages=643–52 |publisher= |location = Canada| issn = | pmid = 18592005 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2435002 }}</ref> [[BUB1B]],<ref name=pmid11535616>{{cite journal |unused_data=DUPLICATE DATA: pmid = 11535614 |last=Sudakin |first=V |authorlink= |coauthors=Chan G K, Yen T J |year=[[2001]]|month=Sep. |title=Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2 |journal=J. Cell Biol. |volume=154 |issue=5 |pages=925–36 |publisher= |location = United States| issn = 0021-9525| pmid = 11535616 |doi = 10.1083/jcb.200102093 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=2196190 }}</ref> [[Estrogen receptor beta]],<ref name=pmid10706629>{{cite journal |last=Poelzl |first=G |authorlink= |coauthors=Kasai Y, Mochizuki N, Shaul P W, Brown M, Mendelsohn M E |year=[[2000]]|month=Mar. |title=Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2 |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=6 |pages=2836–9 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10706629 |doi = 10.1073/pnas.050580997 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16016 }}</ref> [[ADAM17]],<ref name=pmid10527948>{{cite journal |last=Nelson |first=K K |authorlink= |coauthors=Schlöndorff J, Blobel C P |year=[[1999]]|month=Nov. |title=Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta |journal=Biochem. J. |volume=343 Pt 3 |issue= |pages=673–80 |publisher= |location = ENGLAND| issn = 0264-6021| pmid = 10527948 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1220601 }}</ref><ref name=pmid11741929>{{cite journal |last=Poghosyan |first=Zaruhi |authorlink= |coauthors=Robbins Stephen M, Houslay Miles D, Webster Ailsa, Murphy Gillian, Edwards Dylan R |year=[[2002]]|month=Feb. |title=Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases |journal=J. Biol. Chem. |volume=277 |issue=7 |pages=4999–5007 |publisher= |location = United States| issn = 0021-9258| pmid = 11741929 |doi = 10.1074/jbc.M107430200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> [[Ubiquitin D|UBD]],<ref name=pmid10200259>{{cite journal |last=Liu |first=Y C |authorlink= |coauthors=Pan J, Zhang C, Fan W, Collinge M, Bender J R, Weissman S M |year=[[1999]]|month=Apr. |title=A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2 |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=96 |issue=8 |pages=4313–8 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10200259 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1073/pnas.96.8.4313 |pmc=16329 }}</ref> [[CDC27]]<ref name=pmid9736712/><ref name=pmid9628895/> and [[Mad1]].<ref name=pmid16189514>{{cite journal |last=Rual |first=Jean-François |authorlink= |coauthors=Venkatesan Kavitha, Hao Tong, Hirozane-Kishikawa Tomoko, Dricot Amélie, Li Ning, Berriz Gabriel F, Gibbons Francis D, Dreze Matija, Ayivi-Guedehoussou Nono, Klitgord Niels, Simon Christophe, Boxem Mike, Milstein Stuart, Rosenberg Jennifer, Goldberg Debra S, Zhang Lan V, Wong Sharyl L, Franklin Giovanni, Li Siming, Albala Joanna S, Lim Janghoo, Fraughton Carlene, Llamosas Estelle, Cevik Sebiha, Bex Camille, Lamesch Philippe, Sikorski Robert S, Vandenhaute Jean, Zoghbi Huda Y, Smolyar Alex, Bosak Stephanie, Sequerra Reynaldo, Doucette-Stamm Lynn, Cusick Michael E, Hill David E, Roth Frederick P, Vidal Marc |year=[[2005]]|month=Oct. |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=[[Nature (journal)|Nature]] |volume=437 |issue=7062 |pages=1173–8 |publisher= |location = England| issn = | pmid = 16189514 |doi = 10.1038/nature04209 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11707408/><ref name=pmid10660610/>


==References==
==References==

Revision as of 07:50, 2 October 2010

Template:PBB Mitotic spindle assembly checkpoint protein MAD2A is a protein that in humans is encoded by the MAD2L1 gene.[1][2][3]

Template:PBB Summary

Interactions

MAD2L1 has been shown to interact with MAD2L2,[4] CDC20,[5][6][7][8][9][10][11][12][13][14][15][16] BUB1B,[17] Estrogen receptor beta,[18] ADAM17,[19][20] UBD,[21] CDC27[11][12] and Mad1.[22][8][4]

References

  1. ^ Li Y, Benezra R (1996). "Identification of a human mitotic checkpoint gene: hsMAD2". Science. 274 (5285): 246–8. doi:10.1126/science.274.5285.246. PMID 8824189. {{cite journal}}: Unknown parameter |month= ignored (help)
  2. ^ Xu L, Deng HX, Yang Y, Xia JH, Hung WY, Siddque T (1997). "Assignment of mitotic arrest deficient protein 2 (MAD2L1) to human chromosome band 5q23.3 by in situ hybridization". Cytogenet Cell Genet. 78 (1): 63–4. doi:10.1159/000134631. PMID 9345911. {{cite journal}}: Unknown parameter |month= ignored (help)CS1 maint: multiple names: authors list (link)
  3. ^ "Entrez Gene: MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast)".
  4. ^ a b Murakumo, Y (2000). "A human REV7 homolog that interacts with the polymerase zeta catalytic subunit hREV3 and the spindle assembly checkpoint protein hMAD2". J. Biol. Chem. 275 (6). UNITED STATES: 4391–7. doi:10.1074/jbc.275.6.4391. ISSN 0021-9258. PMID 10660610. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  5. ^ Zhang, Y (2001). "Identification of an overlapping binding domain on Cdc20 for Mad2 and anaphase-promoting complex: model for spindle checkpoint regulation". Mol. Cell. Biol. 21 (15). United States: 5190–9. doi:10.1128/MCB.21.15.5190-5199.2001. ISSN 0270-7306. PMC 87243. PMID 11438673. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  6. ^ Sihn, Choong-Ryoul (2003). "p55CDC/hCDC20 mutant induces mitotic catastrophe by inhibiting the MAD2-dependent spindle checkpoint activity in tumor cells". Cancer Lett. 201 (2). Ireland: 203–10. doi:10.1016/S0304-3835(03)00465-8. ISSN 0304-3835. PMID 14607335. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  7. ^ Luo, X (2000). "Structure of the Mad2 spindle assembly checkpoint protein and its interaction with Cdc20". Nat. Struct. Biol. 7 (3). UNITED STATES: 224–9. doi:10.1038/73338. ISSN 1072-8368. PMID 10700282. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  8. ^ a b Sironi, L (2001). "Mad2 binding to Mad1 and Cdc20, rather than oligomerization, is required for the spindle checkpoint". EMBO J. 20 (22). England: 6371–82. doi:10.1093/emboj/20.22.6371. ISSN 0261-4189. PMC 125308. PMID 11707408. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  9. ^ D'Angiolella, Vincenzo (2003). "The spindle checkpoint requires cyclin-dependent kinase activity". Genes Dev. 17 (20). United States: 2520–5. doi:10.1101/gad.267603. ISSN 0890-9369. PMC 218146. PMID 14561775. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  10. ^ Kallio, Marko J (2002). "Rapid microtubule-independent dynamics of Cdc20 at kinetochores and centrosomes in mammalian cells". J. Cell Biol. 158 (5). United States: 841–7. doi:10.1083/jcb.200201135. ISSN 0021-9525. PMC 2173153. PMID 12196507. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  11. ^ a b Wassmann, K (1998). "Mad2 transiently associates with an APC/p55Cdc complex during mitosis". Proc. Natl. Acad. Sci. U.S.A. 95 (19). UNITED STATES: 11193–8. doi:10.1073/pnas.95.19.11193. ISSN 0027-8424. PMC 21618. PMID 9736712. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  12. ^ a b Kallio, M (1998). "Mammalian p55CDC mediates association of the spindle checkpoint protein Mad2 with the cyclosome/anaphase-promoting complex, and is involved in regulating anaphase onset and late mitotic events". J. Cell Biol. 141 (6). UNITED STATES: 1393–406. doi:10.1083/jcb.141.6.1393. ISSN 0021-9525. PMC 2132789. PMID 9628895. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  13. ^ Fang, G (1998). "The checkpoint protein MAD2 and the mitotic regulator CDC20 form a ternary complex with the anaphase-promoting complex to control anaphase initiation". Genes Dev. 12 (12). UNITED STATES: 1871–83. doi:10.1101/gad.12.12.1871. ISSN 0890-9369. PMC 316912. PMID 9637688. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  14. ^ Skoufias, D A (2001). "Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints". Proc. Natl. Acad. Sci. U.S.A. 98 (8). United States: 4492–7. doi:10.1073/pnas.081076898. ISSN 0027-8424. PMC 31862. PMID 11274370. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  15. ^ Nilsson, Jakob (2008). "The APC/C maintains the spindle assembly checkpoint by targeting Cdc20 for destruction". Nat. Cell Biol. 10 (12). England: 1411–20. doi:10.1038/ncb1799. PMC 2635557. PMID 18997788. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |unused_data= ignored (help)CS1 maint: year (link)
  16. ^ Privette, Lisa M (2008). "Loss of CHFR in human mammary epithelial cells causes genomic instability by disrupting the mitotic spindle assembly checkpoint". Neoplasia. 10 (7). Canada: 643–52. PMC 2435002. PMID 18592005. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  17. ^ Sudakin, V (2001). "Checkpoint inhibition of the APC/C in HeLa cells is mediated by a complex of BUBR1, BUB3, CDC20, and MAD2". J. Cell Biol. 154 (5). United States: 925–36. doi:10.1083/jcb.200102093. ISSN 0021-9525. PMC 2196190. PMID 11535616. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help); Unknown parameter |unused_data= ignored (help)CS1 maint: year (link)
  18. ^ Poelzl, G (2000). "Specific association of estrogen receptor beta with the cell cycle spindle assembly checkpoint protein, MAD2". Proc. Natl. Acad. Sci. U.S.A. 97 (6). UNITED STATES: 2836–9. doi:10.1073/pnas.050580997. ISSN 0027-8424. PMC 16016. PMID 10706629. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  19. ^ Nelson, K K (1999). "Evidence for an interaction of the metalloprotease-disintegrin tumour necrosis factor alpha convertase (TACE) with mitotic arrest deficient 2 (MAD2), and of the metalloprotease-disintegrin MDC9 with a novel MAD2-related protein, MAD2beta". Biochem. J. 343 Pt 3. ENGLAND: 673–80. ISSN 0264-6021. PMC 1220601. PMID 10527948. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  20. ^ Poghosyan, Zaruhi (2002). "Phosphorylation-dependent interactions between ADAM15 cytoplasmic domain and Src family protein-tyrosine kinases". J. Biol. Chem. 277 (7). United States: 4999–5007. doi:10.1074/jbc.M107430200. ISSN 0021-9258. PMID 11741929. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: unflagged free DOI (link) CS1 maint: year (link)
  21. ^ Liu, Y C (1999). "A MHC-encoded ubiquitin-like protein (FAT10) binds noncovalently to the spindle assembly checkpoint protein MAD2". Proc. Natl. Acad. Sci. U.S.A. 96 (8). UNITED STATES: 4313–8. doi:10.1073/pnas.96.8.4313. ISSN 0027-8424. PMC 16329. PMID 10200259. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)
  22. ^ Rual, Jean-François (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062). England: 1173–8. doi:10.1038/nature04209. PMID 16189514. {{cite journal}}: Check date values in: |year= (help); Cite has empty unknown parameters: |laydate=, |laysummary=, and |laysource= (help); Unknown parameter |coauthors= ignored (|author= suggested) (help); Unknown parameter |month= ignored (help)CS1 maint: year (link)

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