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Clobetasone: Difference between revisions

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Updating {{drugbox}} (changes to verified fields - updated 'DrugBank_Ref', 'ChEMBL_Ref', 'ChEBI_Ref', 'ChEBI_Ref') per Chem/Drugbox validation (report [[Wikipedia talk:WikiProject_Pharmacology|er
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{{drugbox
{{Drugbox
| Verifiedfields = changed
| Verifiedfields = changed
⚫
| verifiedrevid = 408085844
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| UNII_Ref = {{fdacite|changed|FDA}}
⚫
| UNII = LT69WY1J6D| verifiedrevid = 408085844
|
| IUPAC_name = (1''R'',2''S'',10''S'',11''S'',13''S'',14''R'',15''S'')-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.0<sup>2,7</sup>.0<sup>11,15</sup>]heptadeca-3,6-diene-5,17-dione
| IUPAC_name = (1''R'',2''S'',10''S'',11''S'',13''S'',14''R'',15''S'')-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.0<sup>2,7</sup>.0<sup>11,15</sup>]heptadeca-3,6-diene-5,17-dione
⚫
|synonyms = (8''S'',9''R'',10''S'',13''S'',14''S'',16''S'',17''R'')-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6''H''-cyclopenta[''a'']phenanthrene-3,11-dione
| image = clobetasone.png
| image = clobetasone.png

⚫
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
<!--Clinical data-->
⚫
| ChemSpiderID = 64482
| tradename =
⚫
| InChI = 1/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1
| Drugs.com = {{drugs.com|CONS|clobetasone}}
⚫
| smiles = ClCC(=O)[C@@]2(O)[C@@H](C)C[C@H]1[C@H]4[C@](F)(C(=O)C[C@@]12C)[C@@]/3(/C(=C\C(=O)\C=C\3)CC4)C
⚫
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫
| InChIKey = XXIFVOHLGBURIG-OZCCCYNHBL
⚫
| pregnancy_US = <!-- A / B / C / D / X -->
⚫
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
⚫
| pregnancy_category =
⚫
| StdInChI = 1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1
⚫
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 -->
⚫
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
⚫
| legal_UK = <!-- GSL / P / POM / CD -->
⚫
| StdInChIKey = XXIFVOHLGBURIG-OZCCCYNHSA-N
⚫
| legal_US = <!-- OTC / Rx-only -->
⚫
| legal_status =
⚫
| routes_of_administration = topical

<!--Pharmacokinetic data-->
⚫
| bioavailability =
⚫
| protein_bound =
⚫
| metabolism =
⚫
| elimination_half-life =
⚫
| excretion =

<!--Identifiers-->
| CAS_number = 54063-32-0
| CAS_number = 54063-32-0
| ATC_prefix = D07
| ATC_prefix = D07
| ATC_suffix = AB01
| ATC_suffix = AB01
| ATC_supplemental = {{ATC|S01|BA09}}
| ATC_supplemental = {{ATC|S01|BA09}}
| PubChem = 71387
| PubChem = 71387
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| DrugBank =
⚫
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
⚫
| ChemSpiderID = 64482
⚫
| UNII_Ref = {{fdacite|changed|FDA}}
| UNII = LT69WY1J6D
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D07717
| KEGG = D07717

<!--Chemical data-->
| C=22 | H=26 | Cl=1 | F=1 | O=4
| C=22 | H=26 | Cl=1 | F=1 | O=4
| molecular_weight = 408.891
| molecular_weight = 408.891
⚫
| smiles = ClCC(=O)[C@@]2(O)[C@@H](C)C[C@H]1[C@H]4[C@](F)(C(=O)C[C@@]12C)[C@@]/3(/C(=C\C(=O)\C=C\3)CC4)C
⚫
| bioavailability =
⚫
| InChI = 1/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1
⚫
| protein_bound =
⚫
| InChIKey = XXIFVOHLGBURIG-OZCCCYNHBL
⚫
| metabolism =
⚫
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
⚫
| elimination_half-life =
⚫
| StdInChI = 1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1
⚫
| excretion =
⚫
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
⚫
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
⚫
| StdInChIKey = XXIFVOHLGBURIG-OZCCCYNHSA-N
⚫
| pregnancy_US = <!-- A / B / C / D / X -->
⚫
| synonyms = (8''S'',9''R'',10''S'',13''S'',14''S'',16''S'',17''R'')-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6''H''-cyclopenta[''a'']phenanthrene-3,11-dione
⚫
| pregnancy_category =
⚫
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S8 -->
⚫
| legal_UK = <!-- GSL / P / POM / CD -->
⚫
| legal_US = <!-- OTC / Rx-only -->
⚫
| legal_status =
⚫
| routes_of_administration = topical
}}
}}
'''Clobetasone''' ([[International Nonproprietary Name|INN]]<ref>[http://unstats.un.org/unsd/cr/registry/regcia.asp?Cl=18&Lg=1&Co=C&p=310 United Nations Statistics Division - Classifications Registry - Alphabetical index for HS 2002 Entries starting with 'C' (page 310 of 422)]</ref>) is a [[corticosteroid]] used in [[dermatology]], for treating such skin inflammation as seen in [[eczema]] and other forms of [[dermatitis]], and [[ophthalmology]].
'''Clobetasone''' ([[International Nonproprietary Name|INN]]<ref>[http://unstats.un.org/unsd/cr/registry/regcia.asp?Cl=18&Lg=1&Co=C&p=310 United Nations Statistics Division - Classifications Registry - Alphabetical index for HS 2002 Entries starting with 'C' (page 310 of 422)]</ref>) is a [[corticosteroid]] used in [[dermatology]], for treating such skin inflammation as seen in [[eczema]] and other forms of [[dermatitis]], and [[ophthalmology]].

Revision as of 05:47, 31 August 2011

Clobetasone
Clinical data
Other names(8S,9R,10S,13S,14S,16S,17R)-17-(2-Chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration		topical
ATC code
Identifiers
  • (1R,2S,10S,11S,13S,14R,15S)-14-(2-chloroacetyl)-1-fluoro-14-hydroxy-2,13,15-trimethyltetracyclo[8.7.0.02,7.011,15]heptadeca-3,6-diene-5,17-dione
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.053.576 Edit this at Wikidata
Chemical and physical data
FormulaC22H26ClFO4
Molar mass408.891 g·mol−1
3D model (JSmol)
  • ClCC(=O)[C@@]2(O)[C@@H](C)C[C@H]1[C@H]4[C@](F)(C(=O)C[C@@]12C)[C@@]/3(/C(=C\C(=O)\C=C\3)CC4)C
  • InChI=1S/C22H26ClFO4/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,24)17(26)10-20(16,3)22(12,28)18(27)11-23/h6-7,9,12,15-16,28H,4-5,8,10-11H2,1-3H3/t12-,15-,16-,19-,20-,21-,22-/m0/s1 checkY
  • Key:XXIFVOHLGBURIG-OZCCCYNHSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Clobetasone (INN[1]) is a corticosteroid used in dermatology, for treating such skin inflammation as seen in eczema and other forms of dermatitis, and ophthalmology.

It is available as clobetasone butyrate under the brand name Eumovate[2] or Trimovate,[3] both manufactured by GlaxoSmithKline.

As Trimovate, it also contains Oxytetracycline, an antibiotic, and nystatin, an antifungal[4][5].

References

  1. ^ United Nations Statistics Division - Classifications Registry - Alphabetical index for HS 2002 Entries starting with 'C' (page 310 of 422)
  2. ^ Eumovate cream/ointment, NetDoctor.co.uk
  3. ^ Trimovate cream, NetDoctor.co.uk
  4. ^ 30g Trimovate Cream Box, GSK
  5. ^ Medicines.org.uk - Trimovate info


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