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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=1060}}
{{Infobox_gene}}
'''Centromere protein C 1''' is a [[protein]] that in humans is encoded by the ''CENPC1'' [[gene]].<ref name="pmid7959789">{{cite journal | author = McKay S, Thomson E, Cooke H | title = Sequence homologies and linkage group conservation of the human and mouse Cenpc genes | journal = Genomics | volume = 22 | issue = 1 | pages = 36–40 | year = 1994 | month = Dec | pmid = 7959789 | pmc = | doi = 10.1006/geno.1994.1342 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CENPC1 centromere protein C 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1060| accessdate = }}</ref>
'''Centromere protein C 1''' is a [[protein]] that in humans is encoded by the ''CENPC1'' [[gene]].<ref name="pmid7959789">{{cite journal | vauthors = McKay S, Thomson E, Cooke H | title = Sequence homologies and linkage group conservation of the human and mouse Cenpc genes | journal = Genomics | volume = 22 | issue = 1 | pages = 36–40 |date=Dec 1994 | pmid = 7959789 | doi = 10.1006/geno.1994.1342 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CENPC1 centromere protein C 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1060}}</ref>


⚫
Centromere protein C 1 is a [[centromere]] [[autoantigen]] and a component of the inner [[kinetochore]] plate. The protein is required for maintaining proper [[kinetochore]] size and a timely transition to [[anaphase]]. A putative [[pseudogene]] exists on chromosome 12.<ref name="entrez" />
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
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| summary_text = Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.<ref name="entrez">{{cite web | title = Entrez Gene: CENPC1 centromere protein C 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1060| accessdate = }}</ref>
}}


==References==
==References==
{{reflist}}
{{reflist}}

==External links==
* {{UCSC gene info|CENPC}}

==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
*{{cite journal | vauthors=Saitoh H, Tomkiel J, Cooke CA |title=CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. |journal=Cell |volume=70 |issue= 1 |pages= 115–25 |year= 1992 |pmid= 1339310 |doi=10.1016/0092-8674(92)90538-N |s2cid=22014181 |display-authors=etal}}
{{PBB_Further_reading
*{{cite journal | vauthors=Pluta AF, Earnshaw WC |title=Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18767–74 |year= 1996 |pmid= 8702533 |doi=10.1074/jbc.271.31.18767 |doi-access=free }}
| citations =
*{{cite journal | author=Saitoh H, Tomkiel J, Cooke CA, ''et al.'' |title=CENP-C, an autoantigen in scleroderma, is a component of the human inner kinetochore plate. |journal=Cell |volume=70 |issue= 1 |pages= 115–25 |year= 1992 |pmid= 1339310 |doi=10.1016/0092-8674(92)90538-N }}
*{{cite journal | vauthors=Xie Y, Heng HH |title=FISH mapping of centromere protein C (CENPC) on human chromosome 4q31→q21. |journal=Cytogenet. Cell Genet. |volume=74 |issue= 3 |pages= 192–3 |year= 1996 |pmid= 8941372 |doi=10.1159/000134412 }}
*{{cite journal | author=Pluta AF, Earnshaw WC |title=Specific interaction between human kinetochore protein CENP-C and a nucleolar transcriptional regulator. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18767–74 |year= 1996 |pmid= 8702533 |doi=10.1074/jbc.271.31.18767 }}
*{{cite journal | vauthors=Xie Y, Ni ZM, Gu JR |title=Human chromosome pellicle antibody recognizing centromere protein-C (CENP-C), the main component of the kinetochore. |journal=Cell Res. |volume=7 |issue= 1 |pages= 13–9 |year= 1997 |pmid= 9261558 |doi= 10.1038/cr.1997.2|display-authors=etal|doi-access=free }}
*{{cite journal | author=Xie Y, Heng HH |title=FISH mapping of centromere protein C (CENPC) on human chromosome 4q31→q21. |journal=Cytogenet. Cell Genet. |volume=74 |issue= 3 |pages= 192–3 |year= 1996 |pmid= 8941372 |doi=10.1159/000134412 }}
*{{cite journal | vauthors=Pluta AF, Earnshaw WC, Goldberg IG |title=Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. | series=111 |journal=J. Cell Sci. |volume=( Pt 14) |pages= 2029–41 |year= 1998 |issue=14 |doi=10.1242/jcs.111.14.2029 |pmid= 9645950 }}
*{{cite journal | author=Xie Y, Ni ZM, Gu JR, ''et al.'' |title=Human chromosome pellicle antibody recognizing centromere protein-C (CENP-C), the main component of the kinetochore. |journal=Cell Res. |volume=7 |issue= 1 |pages= 13–9 |year= 1997 |pmid= 9261558 |doi= }}
*{{cite journal | vauthors=Song K, Gronemeyer B, Lu W |title=Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C). |journal=Exp. Cell Res. |volume=275 |issue= 1 |pages= 81–91 |year= 2002 |pmid= 11925107 |doi= 10.1006/excr.2002.5495 |display-authors=etal}}
*{{cite journal | author=Pluta AF, Earnshaw WC, Goldberg IG |title=Interphase-specific association of intrinsic centromere protein CENP-C with HDaxx, a death domain-binding protein implicated in Fas-mediated cell death. |journal=J. Cell. Sci. |volume=111 ( Pt 14) |issue= |pages= 2029–41 |year= 1998 |pmid= 9645950 |doi= }}
*{{cite journal | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |display-authors=etal|doi-access=free }}
*{{cite journal | author=Song K, Gronemeyer B, Lu W, ''et al.'' |title=Mutational analysis of the central centromere targeting domain of human centromere protein C, (CENP-C). |journal=Exp. Cell Res. |volume=275 |issue= 1 |pages= 81–91 |year= 2002 |pmid= 11925107 |doi= 10.1006/excr.2002.5495 }}
*{{cite journal | vauthors=Trazzi S, Bernardoni R, Diolaiti D |title=In vivo functional dissection of human inner kinetochore protein CENP-C. |journal=J. Struct. Biol. |volume=140 |issue= 1–3 |pages= 39–48 |year= 2003 |pmid= 12490152 |doi=10.1016/S1047-8477(02)00506-3 |display-authors=etal}}
*{{cite journal | author=Politi V, Perini G, Trazzi S, ''et al.'' |title=CENP-C binds the alpha-satellite DNA in vivo at specific centromere domains. |journal=J. Cell. Sci. |volume=115 |issue= Pt 11 |pages= 2317–27 |year= 2002 |pmid= 12006616 |doi= }}
*{{cite journal | vauthors=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914–8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200 |doi-access= free }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | vauthors=Suzuki N, Nakano M, Nozaki N |title=CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5934–46 |year= 2004 |pmid= 14612452 |doi= 10.1074/jbc.M306477200 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Trazzi S, Bernardoni R, Diolaiti D, ''et al.'' |title=In vivo functional dissection of human inner kinetochore protein CENP-C. |journal=J. Struct. Biol. |volume=140 |issue= 1-3 |pages= 39–48 |year= 2003 |pmid= 12490152 |doi=10.1016/S1047-8477(02)00506-3 }}
*{{cite journal | vauthors=Obuse C, Yang H, Nozaki N |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=10.1111/j.1365-2443.2004.00705.x |s2cid=21813024 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Rodriguez M, Yu X, Chen J, Songyang Z |title=Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52914–8 |year= 2004 |pmid= 14578343 |doi= 10.1074/jbc.C300407200 }}
*{{cite journal | vauthors=Chung TL, Hsiao HH, Yeh YY |title=In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39653–62 |year= 2004 |pmid= 15272016 |doi= 10.1074/jbc.M405637200 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Suzuki N, Nakano M, Nozaki N, ''et al.'' |title=CENP-B interacts with CENP-C domains containing Mif2 regions responsible for centromere localization. |journal=J. Biol. Chem. |volume=279 |issue= 7 |pages= 5934–46 |year= 2004 |pmid= 14612452 |doi= 10.1074/jbc.M306477200 }}
*{{cite journal | vauthors=Nousiainen M, Silljé HH, Sauer G |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 |bibcode=2006PNAS..103.5391N |display-authors=etal|doi-access=free }}
*{{cite journal | author=Obuse C, Yang H, Nozaki N, ''et al.'' |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=10.1111/j.1365-2443.2004.00705.x }}
*{{cite journal | vauthors=Foltz DR, Jansen LE, Black BE |title=The human CENP-A centromeric nucleosome-associated complex. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 458–69 |year= 2006 |pmid= 16622419 |doi= 10.1038/ncb1397 |s2cid=205286556 |display-authors=etal}}
*{{cite journal | author=Chung TL, Hsiao HH, Yeh YY, ''et al.'' |title=In vitro modification of human centromere protein CENP-C fragments by small ubiquitin-like modifier (SUMO) protein: definitive identification of the modification sites by tandem mass spectrometry analysis of the isopeptides. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 39653–62 |year= 2004 |pmid= 15272016 |doi= 10.1074/jbc.M405637200 }}
*{{cite journal | vauthors=Izuta H, Ikeno M, Suzuki N |title=Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. |journal=Genes Cells |volume=11 |issue= 6 |pages= 673–84 |year= 2006 |pmid= 16716197 |doi= 10.1111/j.1365-2443.2006.00969.x |s2cid=45931410 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Nousiainen M, Silljé HH, Sauer G, ''et al.'' |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103 | pmc=1459365 }}
*{{cite journal | vauthors=Olsen JV, Blagoev B, Gnad F |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |display-authors=etal|doi-access=free }}
*{{cite journal | author=Foltz DR, Jansen LE, Black BE, ''et al.'' |title=The human CENP-A centromeric nucleosome-associated complex. |journal=Nat. Cell Biol. |volume=8 |issue= 5 |pages= 458–69 |year= 2006 |pmid= 16622419 |doi= 10.1038/ncb1397 }}
*{{cite journal | vauthors=Faragher AJ, Sun XM, Butterworth M |title=Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. |journal=Mol. Biol. Cell |volume=18 |issue= 4 |pages= 1337–47 |year= 2007 |pmid= 17287400 |doi= 10.1091/mbc.E06-05-0409 | pmc=1838999 |display-authors=etal}}
*{{cite journal | author=Izuta H, Ikeno M, Suzuki N, ''et al.'' |title=Comprehensive analysis of the ICEN (Interphase Centromere Complex) components enriched in the CENP-A chromatin of human cells. |journal=Genes Cells |volume=11 |issue= 6 |pages= 673–84 |year= 2006 |pmid= 16716197 |doi= 10.1111/j.1365-2443.2006.00969.x }}
*{{cite journal | vauthors=Wong LH, Brettingham-Moore KH, Chan L |title=Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere. |journal=Genome Res. |volume=17 |issue= 8 |pages= 1146–60 |year= 2007 |pmid= 17623812 |doi= 10.1101/gr.6022807 | pmc=1933521 |display-authors=etal}}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Faragher AJ, Sun XM, Butterworth M, ''et al.'' |title=Death receptor-induced apoptosis reveals a novel interplay between the chromosomal passenger complex and CENP-C during interphase. |journal=Mol. Biol. Cell |volume=18 |issue= 4 |pages= 1337–47 |year= 2007 |pmid= 17287400 |doi= 10.1091/mbc.E06-05-0409 | pmc=1838999 }}
*{{cite journal | author=Wong LH, Brettingham-Moore KH, Chan L, ''et al.'' |title=Centromere RNA is a key component for the assembly of nucleoproteins at the nucleolus and centromere. |journal=Genome Res. |volume=17 |issue= 8 |pages= 1146–60 |year= 2007 |pmid= 17623812 |doi= 10.1101/gr.6022807 | pmc=1933521 }}
}}
{{refend}}
{{refend}}


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{{gene-4-stub}}
{{Chromosome genetics}}
{{Chromosome genetics}}



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Latest revision as of 00:33, 15 June 2024

CENPC
Identifiers
AliasesCENPC, CENP-C, CENPC1, MIF2, hcp-4, centromere protein C
External IDsOMIM: 117141; MGI: 99700; HomoloGene: 1371; GeneCards: CENPC; OMA:CENPC - orthologs
Orthologs
SpeciesHumanMouse
Entrez

1060

12617

Ensembl

ENSG00000145241

ENSMUSG00000029253

UniProt

Q03188

P49452

RefSeq (mRNA)

NM_001812
NM_001362481

NM_007683
NM_001345902
NM_001345903
NM_001345904

RefSeq (protein)

NP_001803
NP_001349410

NP_001332831
NP_001332832
NP_001332833
NP_031709

Location (UCSC)Chr 4: 67.47 – 67.55 MbChr 5: 86.16 – 86.21 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Centromere protein C 1 is a protein that in humans is encoded by the CENPC1 gene.[5][6]

Centromere protein C 1 is a centromere autoantigen and a component of the inner kinetochore plate. The protein is required for maintaining proper kinetochore size and a timely transition to anaphase. A putative pseudogene exists on chromosome 12.[6]

References

[edit]
  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000145241 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000029253 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ McKay S, Thomson E, Cooke H (Dec 1994). "Sequence homologies and linkage group conservation of the human and mouse Cenpc genes". Genomics. 22 (1): 36–40. doi:10.1006/geno.1994.1342. PMID 7959789.
  6. ^ a b "Entrez Gene: CENPC1 centromere protein C 1".
[edit]

Further reading

[edit]


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