POLR2L: Difference between revisions

POLR2L
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FLM, 5IYD, 5IYC, 5IY8, 5IYA, 5IYB, 5IY6, 5IY9, 5IY7
Identifiers
Aliases	POLR2L, RBP10, RPABC5, RPB10, RPB10beta, RPB7.6, hRPB7.6, polymerase (RNA) II subunit L, RNA polymerase II subunit L, RNA polymerase II, I and III subunit L
External IDs	OMIM: 601189; MGI: 1913741; HomoloGene: 129854; GeneCards: POLR2L; OMA:POLR2L - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	842,529 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	141,055,045 bp
RNA expression pattern
	Top expressed in
	apex of heart; ; right ventricle; ; left ventricle; ; right auricle; ; myocardium of left ventricle; ; abdominal fat; ; mucosa of transverse colon; ; biceps brachii; ; right adrenal gland; ; body of pancreas;
	Top expressed in
	morula; ; embryo; ; proximal tubule; ; embryo; ; adrenal gland; ; right kidney; ; lens; ; bone marrow; ; yolk sac; ; muscle of thigh;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	DNA binding; zinc ion binding; RNA polymerase II activity; metal ion binding; RNA polymerase III activity; DNA-directed 5'-3' RNA polymerase activity; protein binding; RNA polymerase I activity;
Cellular component	cytosol; nucleoplasm; RNA polymerase I complex; RNA polymerase III complex; RNA polymerase II, core complex; nucleus;
Biological process	termination of RNA polymerase I transcription; mRNA splicing, via spliceosome; epigenetic maintenance of chromatin in transcription-competent conformation; regulation of transcription by RNA polymerase I; transcription initiation from RNA polymerase I promoter; transcription elongation from RNA polymerase II promoter; 7-methylguanosine mRNA capping; transcription by RNA polymerase II; transcription-coupled nucleotide-excision repair; transcription initiation from RNA polymerase II promoter; fibroblast growth factor receptor signaling pathway; transcription by RNA polymerase III; snRNA transcription by RNA polymerase II; RNA metabolic process; regulation of gene silencing by miRNA; transcription, DNA-templated; transcription elongation from RNA polymerase I promoter; positive regulation of type I interferon production; somatic stem cell population maintenance; positive regulation of viral transcription;
	Sources:Amigo / QuickGO
Orthologs
	5441
	66491
	ENSG00000177700
	ENSMUSG00000038489
	P62875
	P62876
	NM_021128
	NM_025593
	NP_066951
	NP_079869
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 19:36, 9 April 2024

DNA-directed RNA polymerases I, II, and III subunit RPABC5 is a protein that in humans is encoded by the POLR2L gene.^[5]

Function

This gene encodes a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.^[6]

Interactions

POLR2L has been shown to interact with POLR2C,^[7] POLR2A,^[7] POLR2B^[7] and POLR2E.^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000177700 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000038489 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M (September 1996). "The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase". Genomics. 32 (1): 86–90. doi:10.1006/geno.1996.0079. PMID 8786124.
^ "Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa".
^ ^a ^b ^c ^d Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. PMID 9201987.

Jeang KT (1998). "Tat, Tat-associated kinase, and transcription". J. Biomed. Sci. 5 (1): 24–7. doi:10.1007/BF02253352. PMID 9570510.
Yankulov K, Bentley D (1998). "Transcriptional control: Tat cofactors and transcriptional elongation". Curr. Biol. 8 (13): R447–9. Bibcode:1998CBio....8.R447Y. doi:10.1016/S0960-9822(98)70289-1. PMID 9651670. S2CID 15480646.
Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A (2000). "Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression". J. Cell. Biochem. 75 (3): 357–68. doi:10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K. PMID 10536359. S2CID 43685090.
Marcello A, Zoppé M, Giacca M (2002). "Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator". IUBMB Life. 51 (3): 175–81. doi:10.1080/152165401753544241. PMID 11547919. S2CID 10931640.
Stevens M, De Clercq E, Balzarini J (2007). "The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention". Med Res Rev. 26 (5): 595–625. doi:10.1002/med.20081. PMC 7168390. PMID 16838299.
Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L (2007). "Will diverse Tat interactions lead to novel antiretroviral drug targets?". Current Drug Targets. 7 (12): 1595–606. doi:10.2174/138945006779025338. PMID 17168834.
Jang KL, Collins MK, Latchman DS (1992). "The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC". J. Acquir. Immune Defic. Syndr. 5 (11): 1142–7. PMID 1403646.
Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG (1992). "HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors". Genes Dev. 6 (4): 655–66. doi:10.1101/gad.6.4.655. PMID 1559613.
Southgate C, Zapp ML, Green MR (1990). "Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein". Nature. 345 (6276): 640–2. Bibcode:1990Natur.345..640S. doi:10.1038/345640a0. PMID 2190099. S2CID 4233742.
Wu-Baer F, Sigman D, Gaynor RB (1995). "Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat". Proc. Natl. Acad. Sci. U.S.A. 92 (16): 7153–7. Bibcode:1995PNAS...92.7153W. doi:10.1073/pnas.92.16.7153. PMC 41297. PMID 7638159.
Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P, Vigneron M (1995). "Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae". Mol. Cell. Biol. 15 (9): 4702–10. doi:10.1128/mcb.15.9.4702. PMC 230713. PMID 7651387.
Herrmann CH, Rice AP (1995). "Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor". J. Virol. 69 (3): 1612–20. doi:10.1128/JVI.69.3.1612-1620.1995. PMC 188757. PMID 7853496.
McKune K, Moore PA, Hull MW, Woychik NA (1996). "Six human RNA polymerase subunits functionally substitute for their yeast counterparts". Mol. Cell. Biol. 15 (12): 6895–900. doi:10.1128/mcb.15.12.6895. PMC 230944. PMID 8524256.
Keen NJ, Gait MJ, Karn J (1996). "Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex". Proc. Natl. Acad. Sci. U.S.A. 93 (6): 2505–10. Bibcode:1996PNAS...93.2505K. doi:10.1073/pnas.93.6.2505. PMC 39827. PMID 8637904.
Yang X, Herrmann CH, Rice AP (1996). "The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function". J. Virol. 70 (7): 4576–84. doi:10.1128/JVI.70.7.4576-4584.1996. PMC 190394. PMID 8676484.
Agostini I, Navarro JM, Rey F, Bouhamdan M, Spire B, Vigne R, Sire J (1996). "The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB". J. Mol. Biol. 261 (5): 599–606. doi:10.1006/jmbi.1996.0485. PMID 8800208.
Zhou Q, Sharp PA (1996). "Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat". Science. 274 (5287): 605–10. Bibcode:1996Sci...274..605Z. doi:10.1126/science.274.5287.605. PMID 8849451. S2CID 13266489.
Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM (1996). "Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II". Proc. Natl. Acad. Sci. U.S.A. 93 (21): 11575–9. Bibcode:1996PNAS...9311575O. doi:10.1073/pnas.93.21.11575. PMC 38099. PMID 8876177.
Chun RF, Jeang KT (1996). "Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1". J. Biol. Chem. 271 (44): 27888–94. doi:10.1074/jbc.271.44.27888. PMID 8910388.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000177700 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000038489 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8786124-5] Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M (September 1996). "The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase". Genomics. 32 (1): 86–90. doi:10.1006/geno.1996.0079. PMID 8786124.

[6] "Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa".

[pmid9201987-7] Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M (July 1997). "Interactions between the human RNA polymerase II subunits". J. Biol. Chem. 272 (27): 16815–21. doi:10.1074/jbc.272.27.16815. PMID 9201987.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=5441}}
+{{cs1 config|name-list-style=vanc}}
-'''DNA-directed RNA polymerases I, II, and III subunit RPABC5''' is a [[protein]] that in humans is encoded by the ''POLR2L'' [[gene]].<ref name="pmid8786124">{{cite journal | author = Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M | title = The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase | journal = Genomics | volume = 32 | issue = 1 | pages = 86–90 |date=September 1996 | pmid = 8786124 | pmc =  | doi = 10.1006/geno.1996.0079 }}</ref>
+{{Infobox_gene}}
+'''DNA-directed RNA polymerases I, II, and III subunit RPABC5''' is a [[protein]] that in humans is encoded by the ''POLR2L'' [[gene]].<ref name="pmid8786124">{{cite journal | vauthors = Acker J, Murroni O, Mattei MG, Kedinger C, Vigneron M | title = The gene (POLR2L) encoding the hRPB7.6 subunit of human RNA polymerase | journal = Genomics | volume = 32 | issue = 1 | pages = 86–90 | date = September 1996 | pmid = 8786124 | doi = 10.1006/geno.1996.0079 }}</ref>
+== Function ==
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = This gene encodes a subunit of [[RNA polymerase]] II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.<ref>{{cite web | title = Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5441| accessdate = }}</ref>
-}}
+This gene encodes a subunit of [[RNA polymerase]] II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. The product of this gene contains four conserved cysteines characteristic of an atypical zinc-binding domain. Like its counterpart in yeast, this subunit may be shared by the other two DNA-directed RNA polymerases.<ref>{{cite web | title = Entrez Gene: POLR2L polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5441}}</ref>
-==Interactions==
-POLR2L has been shown to [[Protein-protein interaction|interact]] with [[POLR2C]],<ref name=pmid9201987>{{cite journal |last=Acker |first=J |authorlink= |author2=de Graaff M |author3=Cheynel I |author4=Khazak V |author5=Kedinger C |author6=Vigneron M  |date=July 1997  |title=Interactions between the human RNA polymerase II subunits |journal=J. Biol. Chem. |volume=272 |issue=27 |pages=16815–21 |publisher= |location = UNITED STATES| issn = 0021-9258| pmid = 9201987 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1074/jbc.272.27.16815 }}</ref> [[POLR2A]],<ref name=pmid9201987/> [[POLR2B]]<ref name=pmid9201987/> and [[POLR2E]].<ref name=pmid9201987/>
-==References==
+== Interactions ==
+POLR2L has been shown to [[Protein-protein interaction|interact]] with [[POLR2C]],<ref name=pmid9201987>{{cite journal | vauthors = Acker J, de Graaff M, Cheynel I, Khazak V, Kedinger C, Vigneron M | title = Interactions between the human RNA polymerase II subunits | journal = J. Biol. Chem. | volume = 272 | issue = 27 | pages = 16815–21 | date = July 1997 | pmid = 9201987 | doi = 10.1074/jbc.272.27.16815 | doi-access = free }}</ref> [[POLR2A]],<ref name=pmid9201987/> [[POLR2B]]<ref name=pmid9201987/> and [[POLR2E]].<ref name=pmid9201987/>
+== References ==
 {{reflist}}
-==Further reading==
+== Further reading ==
 {{refbegin | 2}}
+* {{cite journal | vauthors = Jeang KT | title = Tat, Tat-associated kinase, and transcription. | journal = J. Biomed. Sci. | volume = 5 | issue = 1 | pages = 24–7 | year = 1998 | pmid = 9570510 | doi = 10.1007/BF02253352 }}
-{{PBB_Further_reading
+* {{cite journal | vauthors = Yankulov K, Bentley D | title = Transcriptional control: Tat cofactors and transcriptional elongation. | journal = Curr. Biol. | volume = 8 | issue = 13 | pages = R447–9 | year = 1998 | pmid = 9651670 | doi = 10.1016/S0960-9822(98)70289-1 | s2cid = 15480646 | doi-access = free | bibcode = 1998CBio....8.R447Y }}
-| citations =
-*{{cite journal  | author=Jeang KT |title=Tat, Tat-associated kinase, and transcription. |journal=J. Biomed. Sci. |volume=5 |issue= 1 |pages= 24–7 |year= 1998 |pmid= 9570510 |doi=10.1007/BF02253352  }}
+* {{cite journal | vauthors = Romano G, Kasten M, De Falco G, Micheli P, Khalili K, Giordano A | title = Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression | journal = J. Cell. Biochem. | volume = 75 | issue = 3 | pages = 357–68 | year = 2000 | pmid = 10536359 | doi = 10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K | s2cid = 43685090 }}
-*{{cite journal  | author=Yankulov K, Bentley D |title=Transcriptional control: Tat cofactors and transcriptional elongation. |journal=Curr. Biol. |volume=8 |issue= 13 |pages= R447–9 |year= 1998 |pmid= 9651670 |doi=10.1016/S0960-9822(98)70289-1  }}
+* {{cite journal | vauthors = Marcello A, Zoppé M, Giacca M | title = Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator | journal = IUBMB Life | volume = 51 | issue = 3 | pages = 175–81 | year = 2002 | pmid = 11547919 | doi = 10.1080/152165401753544241 | s2cid = 10931640 | doi-access = free }}
+* {{cite journal | vauthors = Stevens M, De Clercq E, Balzarini J | title = The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention | journal = Med Res Rev | volume = 26 | issue = 5 | pages = 595–625 | year = 2007 | pmid = 16838299 | doi = 10.1002/med.20081 | pmc = 7168390 }}
-*{{cite journal  | author=Romano G |title=Regulatory functions of Cdk9 and of cyclin T1 in HIV tat transactivation pathway gene expression |journal=J. Cell. Biochem. |volume=75 |issue= 3 |pages= 357–68 |year= 2000 |pmid= 10536359 |doi=10.1002/(SICI)1097-4644(19991201)75:3<357::AID-JCB1>3.0.CO;2-K  | author-separator=,  | author2=Kasten M  | author3=De Falco G  | display-authors=3  | last4=Micheli  | first4=Pietro  | last5=Khalili  | first5=Kamel  | last6=Giordano  | first6=Antonio  }}
-*{{cite journal  | author=Marcello A, Zoppé M, Giacca M |title=Multiple modes of transcriptional regulation by the HIV-1 Tat transactivator |journal=IUBMB Life |volume=51 |issue= 3 |pages= 175–81 |year= 2002 |pmid= 11547919 |doi=10.1080/152165401753544241  }}
+* {{cite journal | vauthors = Harrich D, McMillan N, Munoz L, Apolloni A, Meredith L | title = Will diverse Tat interactions lead to novel antiretroviral drug targets? | journal = Current Drug Targets | volume = 7 | issue = 12 | pages = 1595–606 | year = 2007 | pmid = 17168834 | doi = 10.2174/138945006779025338 }}
-*{{cite journal  | author=Stevens M, De Clercq E, Balzarini J |title=The regulation of HIV-1 transcription: molecular targets for chemotherapeutic intervention |journal=Med Res Rev |volume=26 |issue= 5 |pages= 595–625 |year= 2007 |pmid= 16838299 |doi= 10.1002/med.20081 }}
+* {{cite journal | vauthors = Jang KL, Collins MK, Latchman DS | title = The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC | journal = J. Acquir. Immune Defic. Syndr. | volume = 5 | issue = 11 | pages = 1142–7 | year = 1992 | pmid = 1403646 }}
+* {{cite journal | vauthors = Kato H, Sumimoto H, Pognonec P, Chen CH, Rosen CA, Roeder RG | title = HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors | journal = Genes Dev. | volume = 6 | issue = 4 | pages = 655–66 | year = 1992 | pmid = 1559613 | doi = 10.1101/gad.6.4.655 | doi-access = free }}
-*{{cite journal  | author=Harrich D |title=Will diverse Tat interactions lead to novel antiretroviral drug targets? |journal=Current drug targets |volume=7 |issue= 12 |pages= 1595–606 |year= 2007 |pmid= 17168834 |doi=10.2174/138945006779025338  | author-separator=,  | author2=McMillan N  | author3=Munoz L  | display-authors=3  | last4=Apolloni  | first4=Ann  | last5=Meredith  | first5=Luke  }}
-*{{cite journal  | author=Jang KL, Collins MK, Latchman DS |title=The human immunodeficiency virus tat protein increases the transcription of human Alu repeated sequences by increasing the activity of the cellular transcription factor TFIIIC |journal=J. Acquir. Immune Defic. Syndr. |volume=5 |issue= 11 |pages= 1142–7 |year= 1992 |pmid= 1403646 |doi=  }}
+* {{cite journal | vauthors = Southgate C, Zapp ML, Green MR | title = Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein | journal = Nature | volume = 345 | issue = 6276 | pages = 640–2 | year = 1990 | pmid = 2190099 | doi = 10.1038/345640a0 | bibcode = 1990Natur.345..640S | s2cid = 4233742 }}
+* {{cite journal |author3-link=Richard Gaynor| vauthors = Wu-Baer F, Sigman D, Gaynor RB | title = Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 92 | issue = 16 | pages = 7153–7 | year = 1995 | pmid = 7638159 | pmc = 41297 | doi = 10.1073/pnas.92.16.7153 | bibcode = 1995PNAS...92.7153W | doi-access = free }}
-*{{cite journal  | author=Kato H |title=HIV-1 Tat acts as a processivity factor in vitro in conjunction with cellular elongation factors |journal=Genes Dev. |volume=6 |issue= 4 |pages= 655–66 |year= 1992 |pmid= 1559613 |doi=10.1101/gad.6.4.655  | author-separator=,  | author2=Sumimoto H  | author3=Pognonec P  | display-authors=3  | last4=Chen  | first4=C H  | last5=Rosen  | first5=C A  | last6=Roeder  | first6=R G  }}
-*{{cite journal  | author=Southgate C, Zapp ML, Green MR |title=Activation of transcription by HIV-1 Tat protein tethered to nascent RNA through another protein |journal=Nature |volume=345 |issue= 6276 |pages= 640–2 |year= 1990 |pmid= 2190099 |doi= 10.1038/345640a0 }}
+* {{cite journal | vauthors = Shpakovski GV, Acker J, Wintzerith M, Lacroix JF, Thuriaux P, Vigneron M | title = Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae | journal = Mol. Cell. Biol. | volume = 15 | issue = 9 | pages = 4702–10 | year = 1995 | pmid = 7651387 | pmc = 230713 | doi =  10.1128/mcb.15.9.4702}}
-*{{cite journal  | author=Wu-Baer F, Sigman D, Gaynor RB |title=Specific binding of RNA polymerase II to the human immunodeficiency virus trans-activating region RNA is regulated by cellular cofactors and Tat |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 16 |pages= 7153–7 |year= 1995 |pmid= 7638159 |doi=10.1073/pnas.92.16.7153  | pmc=41297  }}
+* {{cite journal | vauthors = Herrmann CH, Rice AP | title = Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor | journal = J. Virol. | volume = 69 | issue = 3 | pages = 1612–20 | year = 1995 | pmid = 7853496 | pmc = 188757 | doi =  10.1128/JVI.69.3.1612-1620.1995}}
-*{{cite journal  | author=Shpakovski GV |title=Four subunits that are shared by the three classes of RNA polymerase are functionally interchangeable between Homo sapiens and Saccharomyces cerevisiae |journal=Mol. Cell. Biol. |volume=15 |issue= 9 |pages= 4702–10 |year= 1995 |pmid= 7651387 |doi=  | pmc=230713  | author-separator=,  | author2=Acker J  | author3=Wintzerith M  | display-authors=3  | last4=Lacroix  | first4=JF  | last5=Thuriaux  | first5=P  | last6=Vigneron  | first6=M  }}
+* {{cite journal | vauthors = McKune K, Moore PA, Hull MW, Woychik NA | title = Six human RNA polymerase subunits functionally substitute for their yeast counterparts | journal = Mol. Cell. Biol. | volume = 15 | issue = 12 | pages = 6895–900 | year = 1996 | pmid = 8524256 | pmc = 230944 | doi =  10.1128/mcb.15.12.6895}}
-*{{cite journal  | author=Herrmann CH, Rice AP |title=Lentivirus Tat proteins specifically associate with a cellular protein kinase, TAK, that hyperphosphorylates the carboxyl-terminal domain of the large subunit of RNA polymerase II: candidate for a Tat cofactor |journal=J. Virol. |volume=69 |issue= 3 |pages= 1612–20 |year= 1995 |pmid= 7853496 |doi=  | pmc=188757  }}
+* {{cite journal | vauthors = Keen NJ, Gait MJ, Karn J | title = Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 6 | pages = 2505–10 | year = 1996 | pmid = 8637904 | pmc = 39827 | doi = 10.1073/pnas.93.6.2505 | bibcode = 1996PNAS...93.2505K | doi-access = free }}
-*{{cite journal  | author=McKune K, Moore PA, Hull MW, Woychik NA |title=Six human RNA polymerase subunits functionally substitute for their yeast counterparts |journal=Mol. Cell. Biol. |volume=15 |issue= 12 |pages= 6895–900 |year= 1996 |pmid= 8524256 |doi=  | pmc=230944  }}
+* {{cite journal | vauthors = Yang X, Herrmann CH, Rice AP | title = The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function | journal = J. Virol. | volume = 70 | issue = 7 | pages = 4576–84 | year = 1996 | pmid = 8676484 | pmc = 190394 | doi =  10.1128/JVI.70.7.4576-4584.1996}}
-*{{cite journal  | author=Keen NJ, Gait MJ, Karn J |title=Human immunodeficiency virus type-1 Tat is an integral component of the activated transcription-elongation complex |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 6 |pages= 2505–10 |year= 1996 |pmid= 8637904 |doi=10.1073/pnas.93.6.2505  | pmc=39827  }}
+* {{cite journal | vauthors = Agostini I, Navarro JM, Rey F, Bouhamdan M, Spire B, Vigne R, Sire J | title = The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB | journal = J. Mol. Biol. | volume = 261 | issue = 5 | pages = 599–606 | year = 1996 | pmid = 8800208 | doi = 10.1006/jmbi.1996.0485 }}
-*{{cite journal  | author=Yang X, Herrmann CH, Rice AP |title=The human immunodeficiency virus Tat proteins specifically associate with TAK in vivo and require the carboxyl-terminal domain of RNA polymerase II for function |journal=J. Virol. |volume=70 |issue= 7 |pages= 4576–84 |year= 1996 |pmid= 8676484 |doi=  | pmc=190394  }}
+* {{cite journal | vauthors = Zhou Q, Sharp PA | title = Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat | journal = Science | volume = 274 | issue = 5287 | pages = 605–10 | year = 1996 | pmid = 8849451 | doi = 10.1126/science.274.5287.605 | bibcode = 1996Sci...274..605Z | s2cid = 13266489 }}
+* {{cite journal | vauthors = Okamoto H, Sheline CT, Corden JL, Jones KA, Peterlin BM | title = Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 93 | issue = 21 | pages = 11575–9 | year = 1996 | pmid = 8876177 | pmc = 38099 | doi = 10.1073/pnas.93.21.11575 | bibcode = 1996PNAS...9311575O | doi-access = free }}
-*{{cite journal  | author=Agostini I |title=The human immunodeficiency virus type 1 Vpr transactivator: cooperation with promoter-bound activator domains and binding to TFIIB |journal=J. Mol. Biol. |volume=261 |issue= 5 |pages= 599–606 |year= 1996 |pmid= 8800208 |doi= 10.1006/jmbi.1996.0485  | author-separator=,  | author2=Navarro JM  | author3=Rey F  | display-authors=3  | last4=Bouhamdan  | first4=M  | last5=Spire  | first5=B  | last6=Vigne  | first6=R  | last7=Sire  | first7=J }}
-*{{cite journal  | author=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat |journal=Science |volume=274 |issue= 5287 |pages= 605–10 |year= 1996 |pmid= 8849451 |doi=10.1126/science.274.5287.605  }}
+* {{cite journal | vauthors = Chun RF, Jeang KT | title = Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1 | journal = J. Biol. Chem. | volume = 271 | issue = 44 | pages = 27888–94 | year = 1996 | pmid = 8910388 | doi = 10.1074/jbc.271.44.27888 | doi-access = free }}
-*{{cite journal  | author=Okamoto H |title=Trans-activation by human immunodeficiency virus Tat protein requires the C-terminal domain of RNA polymerase II |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 21 |pages= 11575–9 |year= 1996 |pmid= 8876177 |doi=10.1073/pnas.93.21.11575  | pmc=38099  | author-separator=,  | author2=Sheline CT  | author3=Corden JL  | display-authors=3  | last4=Jones  | first4=KA  | last5=Peterlin  | first5=BM  }}
-*{{cite journal  | author=Chun RF, Jeang KT |title=Requirements for RNA polymerase II carboxyl-terminal domain for activated transcription of human retroviruses human T-cell lymphotropic virus I and HIV-1 |journal=J. Biol. Chem. |volume=271 |issue= 44 |pages= 27888–94 |year= 1996 |pmid= 8910388 |doi=10.1074/jbc.271.44.27888  }}
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