IL3RA: Difference between revisions

IL3RA
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4JZJ
Identifiers
Aliases	IL3RA, CD123, IL3R, IL3RAY, IL3RX, IL3RY, hIL-3Ra, interleukin 3 receptor subunit alpha
External IDs	OMIM: 308385, 430000; MGI: 96553; HomoloGene: 48088; GeneCards: IL3RA; OMA:IL3RA - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	1,382,689 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	8,123,488 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; right hemisphere of cerebellum; ; left ovary; ; upper lobe of left lung; ; right ovary; ; sural nerve; ; left uterine tube; ; muscle layer of sigmoid colon; ; body of uterus; ; apex of heart;
	Top expressed in
	granulocyte; ; yolk sac; ; stroma of bone marrow; ; embryo; ; seminiferous tubule; ; thymus; ; spermatocyte; ; epiblast; ; embryo; ; muscle of thigh;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cytokine receptor activity; interleukin-3 receptor activity; protein tyrosine kinase activity; cytokine binding;
Cellular component	integral component of membrane; plasma membrane; membrane; intracellular anatomical structure; external side of plasma membrane; receptor complex;
Biological process	MAPK cascade; cellular response to interleukin-3; peptidyl-tyrosine phosphorylation; interleukin-3-mediated signaling pathway; cytokine-mediated signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3563
	16188
	ENSG00000185291
	ENSMUSG00000068758
	P26951
	P26952
	NM_001267713; NM_002183
	NM_008369
	NP_001254642; NP_002174
	NP_032395
	Wikidata
View/Edit Human	View/Edit Mouse

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Latest revision as of 11:33, 13 January 2024

Interleukin 3 receptor, alpha (low affinity) (IL3RA), also known as CD123 (Cluster of Differentiation 123), is a human gene.^[5]

Function

The protein encoded by this gene is an interleukin 3 specific subunit of a heterodimeric cytokine receptor. The receptor is composed of a ligand specific alpha subunit and a signal transducing beta subunit shared by the receptors for interleukin 3 (IL3), colony stimulating factor 2 (CSF2/GM-CSF), and interleukin 5 (IL5). The binding of this protein to IL3 depends on the beta subunit. The beta subunit is activated by the ligand binding, and is required for the biological activities of IL3. This gene and the gene encoding the colony stimulating factor 2 receptor alpha chain (CSF2RA) form a cytokine receptor gene cluster in a X-Y pseudoautosomal region on chromosomes X or Y.^[5]

Interactions

IL3RA has been shown to interact with Interleukin 3.^[6]^[7]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000185291 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000068758 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: IL3RA interleukin 3 receptor, alpha (low affinity)".
^ Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (June 1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. 16 (6): 3035–46. doi:10.1128/MCB.16.6.3035. PMC 231298. PMID 8649415.
^ Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

Hara T, Miyajima A (1996). "Function and signal transduction mediated by the interleukin 3 receptor system in hematopoiesis". Stem Cells. 14 (6): 605–18. doi:10.1002/stem.140605. PMID 8948019. S2CID 45074046.
Testa U, Riccioni R, Diverio D, Rossini A, Lo Coco F, Peschle C (2004). "Interleukin-3 receptor in acute leukemia". Leukemia. 18 (2): 219–26. doi:10.1038/sj.leu.2403224. PMID 14671644.
Kitamura T, Sato N, Arai K, Miyajima A (1991). "Expression cloning of the human IL-3 receptor cDNA reveals a shared beta subunit for the human IL-3 and GM-CSF receptors". Cell. 66 (6): 1165–74. doi:10.1016/0092-8674(91)90039-2. PMID 1833064. S2CID 42948973.
Machide M, Mano H, Todokoro K (1995). "Interleukin 3 and erythropoietin induce association of Vav with Tec kinase through Tec homology domain". Oncogene. 11 (4): 619–25. PMID 7651724.
Yoshimura A, Ohkubo T, Kiguchi T, Jenkins NA, Gilbert DJ, Copeland NG, Hara T, Miyajima A (1995). "A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors". EMBO J. 14 (12): 2816–26. doi:10.1002/j.1460-2075.1995.tb07281.x. PMC 398400. PMID 7796808.
Kosugi H, Nakagawa Y, Hotta T, Saito H, Miyajima A, Arai K, Yokota T (1995). "Structure of the gene encoding the alpha subunit of the human interleukin 3 receptor". Biochem. Biophys. Res. Commun. 208 (1): 360–7. doi:10.1006/bbrc.1995.1346. PMID 7887951.
Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.
Kremer E, Baker E, D'Andrea RJ, Slim R, Phillips H, Moretti PA, Lopez AF, Petit C, Vadas MA, Sutherland GR (1993). "A cytokine receptor gene cluster in the X-Y pseudoautosomal region?". Blood. 82 (1): 22–8. doi:10.1182/blood.V82.1.22.bloodjournal82122. PMID 8100720.
Milatovich A, Kitamura T, Miyajima A, Francke U (1993). "Gene for the alpha-subunit of the human interleukin-3 receptor (IL3RA) localized to the X-Y pseudoautosomal region". Am. J. Hum. Genet. 53 (5): 1146–53. PMC 1682314. PMID 8213838.
Macardle PJ, Chen Z, Shih CY, Huang CM, Weedon H, Sun Q, Lopez AF, Zola H (1996). "Characterization of human leucocytes bearing the IL-3 receptor". Cell. Immunol. 168 (1): 59–68. doi:10.1006/cimm.1996.0049. PMID 8599840.
Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. 16 (6): 3035–46. doi:10.1128/MCB.16.6.3035. PMC 231298. PMID 8649415.
Bagley CJ, Phillips J, Cambareri B, Vadas MA, Lopez AF (1996). "A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor". J. Biol. Chem. 271 (50): 31922–8. doi:10.1074/jbc.271.50.31922. PMID 8943237.
Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP (1997). "The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling". J. Biol. Chem. 272 (36): 22630–41. doi:10.1074/jbc.272.36.22630. PMID 9278420.
Wang P, Wu P, Cheewatrakoolpong B, Myers JG, Egan RW, Billah MM (1998). "Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils". J. Immunol. 160 (9): 4427–32. doi:10.4049/jimmunol.160.9.4427. PMID 9574547.
Res PC, Couwenberg F, Vyth-Dreese FA, Spits H (1999). "Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus". Blood. 94 (8): 2647–57. doi:10.1182/blood.V94.8.2647.420k06_2647_2657. PMID 10515868. S2CID 36813728.
Jahnsen FL, Lund-Johansen F, Dunne JF, Farkas L, Haye R, Brandtzaeg P (2000). "Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy". J. Immunol. 165 (7): 4062–8. doi:10.4049/jimmunol.165.7.4062. PMID 11034417.
Heinemann A, Hartnell A, Stubbs VE, Murakami K, Soler D, LaRosa G, Askenase PW, Williams TJ, Sabroe I (2000). "Basophil responses to chemokines are regulated by both sequential and cooperative receptor signaling". J. Immunol. 165 (12): 7224–33. doi:10.4049/jimmunol.165.12.7224. PMID 11120855.
Carr PD, Gustin SE, Church AP, Murphy JM, Ford SC, Mann DA, Woltring DM, Walker I, Ollis DL, Young IG (2001). "Structure of the complete extracellular domain of the common beta subunit of the human GM-CSF, IL-3, and IL-5 receptors reveals a novel dimer configuration". Cell. 104 (2): 291–300. doi:10.1016/S0092-8674(01)00213-6. PMID 11207369. S2CID 14494146.
Kunitani H, Shimizu Y, Murata H, Higuchi K, Watanabe A (2002). "Phenotypic analysis of circulating and intrahepatic dendritic cell subsets in patients with chronic liver diseases". J. Hepatol. 36 (6): 734–41. doi:10.1016/S0168-8278(02)00062-4. PMID 12044522.

External links

IL3RA+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000185291 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000068758 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: IL3RA interleukin 3 receptor, alpha (low affinity)".

[pmid8649415-6] Stomski FC, Sun Q, Bagley CJ, Woodcock J, Goodall G, Andrews RK, Berndt MC, Lopez AF (June 1996). "Human interleukin-3 (IL-3) induces disulfide-linked IL-3 receptor alpha- and beta-chain heterodimerization, which is required for receptor activation but not high-affinity binding". Mol. Cell. Biol. 16 (6): 3035–46. doi:10.1128/MCB.16.6.3035. PMC 231298. PMID 8649415.

[pmid7957082-7] Woodcock JM, Zacharakis B, Plaetinck G, Bagley CJ, Qiyu S, Hercus TR, Tavernier J, Lopez AF (November 1994). "Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF". EMBO J. 13 (21): 5176–85. doi:10.1002/j.1460-2075.1994.tb06848.x. PMC 395466. PMID 7957082.

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@@ Line 1: / Line 1: @@
 {{Short description|Human gene}}
+{{cs1 config|name-list-style=vanc}}
 {{Infobox_gene}}
 '''Interleukin 3 receptor, alpha (low affinity)''' ('''IL3RA'''), also known as '''CD123''' ('''C'''luster of '''D'''ifferentiation 123), is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: IL3RA interleukin 3 receptor, alpha (low affinity)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3563}}</ref>
@@ Line 30: / Line 31: @@
 * {{cite journal | vauthors = Bagley CJ, Phillips J, Cambareri B, Vadas MA, Lopez AF | title = A discontinuous eight-amino acid epitope in human interleukin-3 binds the alpha-chain of its receptor | journal = J. Biol. Chem. | volume = 271 | issue = 50 | pages = 31922–8 | year = 1996 | pmid = 8943237 | doi = 10.1074/jbc.271.50.31922 | doi-access = free }}
 * {{cite journal | vauthors = Klein BK, Feng Y, McWherter CA, Hood WF, Paik K, McKearn JP | title = The receptor binding site of human interleukin-3 defined by mutagenesis and molecular modeling | journal = J. Biol. Chem. | volume = 272 | issue = 36 | pages = 22630–41 | year = 1997 | pmid = 9278420 | doi = 10.1074/jbc.272.36.22630 | doi-access = free }}
-* {{cite journal | vauthors = Wang P, Wu P, Cheewatrakoolpong B, Myers JG, Egan RW, Billah MM | title = Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils | journal = J. Immunol. | volume = 160 | issue = 9 | pages = 4427–32 | year = 1998 | pmid = 9574547 }}
+* {{cite journal | vauthors = Wang P, Wu P, Cheewatrakoolpong B, Myers JG, Egan RW, Billah MM | title = Selective inhibition of IL-5 receptor alpha-chain gene transcription by IL-5, IL-3, and granulocyte-macrophage colony-stimulating factor in human blood eosinophils | journal = J. Immunol. | volume = 160 | issue = 9 | pages = 4427–32 | year = 1998 | doi = 10.4049/jimmunol.160.9.4427 | pmid = 9574547 }}
 * {{cite journal | vauthors = Res PC, Couwenberg F, Vyth-Dreese FA, Spits H | title = Expression of pTalpha mRNA in a committed dendritic cell precursor in the human thymus | journal = Blood | volume = 94 | issue = 8 | pages = 2647–57 | year = 1999 | pmid = 10515868 | doi =  10.1182/blood.V94.8.2647.420k06_2647_2657| s2cid = 36813728 }}
 * {{cite journal | vauthors = Jahnsen FL, Lund-Johansen F, Dunne JF, Farkas L, Haye R, Brandtzaeg P | title = Experimentally induced recruitment of plasmacytoid (CD123high) dendritic cells in human nasal allergy | journal = J. Immunol. | volume = 165 | issue = 7 | pages = 4062–8 | year = 2000 | pmid = 11034417 | doi = 10.4049/jimmunol.165.7.4062 | doi-access = free }}

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350