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{{Short description|Protein-coding gene in the species Homo sapiens}} |
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{{Infobox_gene}} |
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'''Leukocyte immunoglobulin-like receptor subfamily A member 4''' (LILR-A5) also known as '''CD85 antigen-like family member G''' (CD85g), and '''immunoglobulin-like transcript 7''' (ILT-7) is a [[protein]] that in humans is encoded by the ''LILRA4'' [[gene]].<ref name="pmid10941842">{{cite journal |vauthors=Wende H, Volz A, Ziegler A | title = Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster | journal = Immunogenetics | volume = 51 | issue = 8–9 | pages = 703–13 |date=Sep 2000 | pmid = 10941842 | doi =10.1007/s002510000187 | s2cid = 20719684 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23547}}</ref> |
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⚫ | This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a [[leukocyte immunoglobulin-like receptor]] gene cluster (LRC) at chromosomal region 19q13.4.<ref name="entrez" /> |
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{{GNF_Protein_box |
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| image = |
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| image_source = |
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| PDB = |
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| Name = Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4 |
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| HGNCid = 15503 |
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| Symbol = LILRA4 |
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| AltSymbols =; CD85g; ILT7; MGC129597; MGC129598 |
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| OMIM = 607517 |
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| ECnumber = |
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| Homologene = 69118 |
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| MGIid = |
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| GeneAtlas_image1 = PBB_GE_LILRA4_210313_at_tn.png |
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| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} |
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| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} |
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| Process = {{GNF_GO|id=GO:0006955 |text = immune response}} |
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| Orthologs = {{GNF_Ortholog_box |
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| Hs_EntrezGene = 23547 |
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| Hs_Ensembl = ENSG00000170858 |
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| Hs_RefseqProtein = NP_036408 |
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| Hs_RefseqmRNA = NM_012276 |
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| Hs_GenLoc_db = |
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| Hs_GenLoc_chr = 19 |
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| Hs_GenLoc_start = 59536505 |
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| Hs_GenLoc_end = 59542233 |
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| Hs_Uniprot = P59901 |
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| Mm_EntrezGene = |
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| Mm_Ensembl = |
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| Mm_RefseqmRNA = |
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| Mm_RefseqProtein = |
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| Mm_GenLoc_db = |
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| Mm_GenLoc_chr = |
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| Mm_GenLoc_start = |
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| Mm_GenLoc_end = |
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| Mm_Uniprot = |
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}} |
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}} |
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'''Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4''', also known as '''LILRA4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23547| accessdate = }}</ref> |
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{{PBB_Summary |
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| section_title = |
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⚫ | |||
}} |
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==References== |
==References== |
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{{reflist}} |
{{reflist}} |
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==Further reading== |
==Further reading== |
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{{refbegin | 2}} |
{{refbegin | 2}} |
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*{{cite journal |vauthors=Cho M, Ishida K, Chen J, etal |title=SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production |journal=Int. Immunol. |volume=20 |issue= 1 |pages= 155–64 |year= 2008 |pmid= 18048391 |doi= 10.1093/intimm/dxm127 |doi-access= }} |
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{{PBB_Further_reading |
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*{{cite journal |vauthors=Sellick GS, Wade R, Richards S, etal |title=Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis |journal=Blood |volume=111 |issue= 3 |pages= 1625–33 |year= 2008 |pmid= 18006695 |doi= 10.1182/blood-2007-08-110130 |doi-access= free }} |
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| citations = |
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*{{cite journal | |
*{{cite journal |vauthors=Zhan X, Desiderio DM |title=Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry |journal=Anal. Biochem. |volume=354 |issue= 2 |pages= 279–89 |year= 2006 |pmid= 16777052 |doi= 10.1016/j.ab.2006.05.024 }} |
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*{{cite journal |
*{{cite journal |vauthors=Cao W, Rosen DB, Ito T, etal |title=Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production |journal=J. Exp. Med. |volume=203 |issue= 6 |pages= 1399–405 |year= 2006 |pmid= 16735691 |doi= 10.1084/jem.20052454 | pmc=2118323 }} |
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*{{cite journal |
*{{cite journal |vauthors=Ju XS, Hacker C, Scherer B, etal |title=Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation |journal=Gene |volume=331 |pages= 159–64 |year= 2004 |pmid= 15094202 |doi= 10.1016/j.gene.2004.02.018 }} |
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*{{cite journal |
*{{cite journal |vauthors=Tedla N, Bandeira-Melo C, Tassinari P, etal |title=Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 1174–9 |year= 2003 |pmid= 12529506 |doi= 10.1073/pnas.0337567100 | pmc=298746 |bibcode=2003PNAS..100.1174T |doi-access=free }} |
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*{{cite journal |
*{{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }} |
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*{{cite journal | |
*{{cite journal |vauthors=Rissoan MC, Duhen T, Bridon JM, etal |title=Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells |journal=Blood |volume=100 |issue= 9 |pages= 3295–303 |year= 2002 |pmid= 12384430 |doi= 10.1182/blood-2002-02-0638 |doi-access= free }} |
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*{{cite journal |
*{{cite journal |vauthors=Young NT, Canavez F, Uhrberg M, etal |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270–8 |year= 2001 |pmid= 11491530 |doi=10.1007/s002510100332 |s2cid=2819935 }} |
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*{{cite journal | author=Rissoan MC, Duhen T, Bridon JM, ''et al.'' |title=Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. |journal=Blood |volume=100 |issue= 9 |pages= 3295–303 |year= 2002 |pmid= 12384430 |doi= 10.1182/blood-2002-02-0638 }} |
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*{{cite journal | author=Young NT, Canavez F, Uhrberg M, ''et al.'' |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270–8 |year= 2001 |pmid= 11491530 |doi= }} |
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*{{cite journal | author=Wende H, Volz A, Ziegler A |title=Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. |journal=Immunogenetics |volume=51 |issue= 8-9 |pages= 703–13 |year= 2000 |pmid= 10941842 |doi= }} |
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}} |
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{{refend}} |
{{refend}} |
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{{gene-19-stub}} |
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[[Category:Immunoglobulin superfamily]] |
Latest revision as of 01:18, 3 December 2023
Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known as CD85 antigen-like family member G (CD85g), and immunoglobulin-like transcript 7 (ILT-7) is a protein that in humans is encoded by the LILRA4 gene.[3][4]
This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.[4]
References
[edit]- ^ a b c ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
- ^ a b "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".
Further reading
[edit]- Cho M, Ishida K, Chen J, et al. (2008). "SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production". Int. Immunol. 20 (1): 155–64. doi:10.1093/intimm/dxm127. PMID 18048391.
- Sellick GS, Wade R, Richards S, et al. (2008). "Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis". Blood. 111 (3): 1625–33. doi:10.1182/blood-2007-08-110130. PMID 18006695.
- Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
- Cao W, Rosen DB, Ito T, et al. (2006). "Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production". J. Exp. Med. 203 (6): 1399–405. doi:10.1084/jem.20052454. PMC 2118323. PMID 16735691.
- Ju XS, Hacker C, Scherer B, et al. (2004). "Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation". Gene. 331: 159–64. doi:10.1016/j.gene.2004.02.018. PMID 15094202.
- Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. Bibcode:2003PNAS..100.1174T. doi:10.1073/pnas.0337567100. PMC 298746. PMID 12529506.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Rissoan MC, Duhen T, Bridon JM, et al. (2002). "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood. 100 (9): 3295–303. doi:10.1182/blood-2002-02-0638. PMID 12384430.
- Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530. S2CID 2819935.