LILRA4: Difference between revisions

LILRA4
Identifiers
Aliases	LILRA4, CD85g, ILT7, leukocyte immunoglobulin like receptor A4
External IDs	OMIM: 607517; HomoloGene: 69118; GeneCards: LILRA4; OMA:LILRA4 - orthologs
Gene location (Human)
Chr.	Chromosome 19 (human)
End	54,339,162 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; spleen; ; testicle; ; lymph node; ; monocyte; ; blood; ; appendix; ; C1 segment; ; gonad; ; substantia nigra;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; signaling receptor binding; coreceptor activity;
Cellular component	membrane; integral component of membrane; integral component of plasma membrane; Fc-epsilon receptor I complex; plasma membrane;
Biological process	immune system process; negative regulation of interferon-alpha production; negative regulation of tumor necrosis factor production; negative regulation of toll-like receptor 7 signaling pathway; negative regulation of toll-like receptor 9 signaling pathway; Fc-epsilon receptor signaling pathway; innate immune response;
	Sources:Amigo / QuickGO
Orthologs
	23547
	n/a
	ENSG00000277092; ENSG00000276798; ENSG00000274185; ENSG00000239961
	n/a
	P59901
	n/a
	NM_012276
	n/a
	NP_036408
	n/a
	Wikidata
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Latest revision as of 01:18, 3 December 2023

Leukocyte immunoglobulin-like receptor subfamily A member 4 (LILR-A5) also known as CD85 antigen-like family member G (CD85g), and immunoglobulin-like transcript 7 (ILT-7) is a protein that in humans is encoded by the LILRA4 gene.^[3]^[4]

This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte immunoglobulin-like receptor gene cluster (LRC) at chromosomal region 19q13.4.^[4]

References

^ ^a ^b ^c ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.
^ ^a ^b "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

Cho M, Ishida K, Chen J, et al. (2008). "SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production". Int. Immunol. 20 (1): 155–64. doi:10.1093/intimm/dxm127. PMID 18048391.
Sellick GS, Wade R, Richards S, et al. (2008). "Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis". Blood. 111 (3): 1625–33. doi:10.1182/blood-2007-08-110130. PMID 18006695.
Zhan X, Desiderio DM (2006). "Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry". Anal. Biochem. 354 (2): 279–89. doi:10.1016/j.ab.2006.05.024. PMID 16777052.
Cao W, Rosen DB, Ito T, et al. (2006). "Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production". J. Exp. Med. 203 (6): 1399–405. doi:10.1084/jem.20052454. PMC 2118323. PMID 16735691.
Ju XS, Hacker C, Scherer B, et al. (2004). "Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation". Gene. 331: 159–64. doi:10.1016/j.gene.2004.02.018. PMID 15094202.
Tedla N, Bandeira-Melo C, Tassinari P, et al. (2003). "Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7". Proc. Natl. Acad. Sci. U.S.A. 100 (3): 1174–9. Bibcode:2003PNAS..100.1174T. doi:10.1073/pnas.0337567100. PMC 298746. PMID 12529506.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Rissoan MC, Duhen T, Bridon JM, et al. (2002). "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells". Blood. 100 (9): 3295–303. doi:10.1182/blood-2002-02-0638. PMID 12384430.
Young NT, Canavez F, Uhrberg M, et al. (2001). "Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex". Immunogenetics. 53 (4): 270–8. doi:10.1007/s002510100332. PMID 11491530. S2CID 2819935.

[refGRCh38Ensembl-1] ENSG00000276798, ENSG00000274185, ENSG00000239961 GRCh38: Ensembl release 89: ENSG00000277092, ENSG00000276798, ENSG00000274185, ENSG00000239961 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10941842-3] Wende H, Volz A, Ziegler A (Sep 2000). "Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster". Immunogenetics. 51 (8–9): 703–13. doi:10.1007/s002510000187. PMID 10941842. S2CID 20719684.

[entrez-4] "Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4".

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Leukocyte immunoglobulin-like receptor subfamily A member 4''' (LILR-A5) also known as '''CD85 antigen-like family member G''' (CD85g), and '''immunoglobulin-like transcript 7''' (ILT-7) is a [[protein]] that in humans is encoded by the ''LILRA4'' [[gene]].<ref name="pmid10941842">{{cite journal |vauthors=Wende H, Volz A, Ziegler A | title = Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster | journal = Immunogenetics | volume = 51 | issue = 8–9 | pages = 703–13 |date=Sep 2000 | pmid = 10941842 | doi =10.1007/s002510000187  | s2cid = 20719684 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23547}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
+This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a [[leukocyte immunoglobulin-like receptor]] gene cluster (LRC) at chromosomal region 19q13.4.<ref name="entrez" />
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4
- | HGNCid = 15503
- | Symbol = LILRA4
- | AltSymbols =; CD85g; ILT7; MGC129597; MGC129598
- | OMIM = 607517
- | ECnumber =
- | Homologene = 69118
- | MGIid =
- | GeneAtlas_image1 = PBB_GE_LILRA4_210313_at_tn.png
- | Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006955 |text = immune response}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 23547
-    | Hs_Ensembl = ENSG00000170858
-    | Hs_RefseqProtein = NP_036408
-    | Hs_RefseqmRNA = NM_012276
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 19
-    | Hs_GenLoc_start = 59536505
-    | Hs_GenLoc_end = 59542233
-    | Hs_Uniprot = P59901
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4''', also known as '''LILRA4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23547| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{PBB_Summary
-| section_title =
-| summary_text = This gene encodes an immunoglobulin-like cell surface protein preferentially expressed in plasmacytoid dendritic cells (PDCs). This gene is highly expressed in PDCs, and is found to be rapidly down-regulated by interleukin 3 (IL3). This gene is one of the 19 highly related genes that form a leukocyte receptor gene cluster (LRC) at chromosomal region 19q13.4.<ref name="entrez">{{cite web | title = Entrez Gene: LILRA4 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23547| accessdate = }}</ref>
-}}
 ==References==
 {{reflist}}
 ==Further reading==
 {{refbegin | 2}}
+*{{cite journal   |vauthors=Cho M, Ishida K, Chen J, etal |title=SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production |journal=Int. Immunol. |volume=20 |issue= 1 |pages= 155–64 |year= 2008 |pmid= 18048391 |doi= 10.1093/intimm/dxm127 |doi-access=  }}
-{{PBB_Further_reading
+*{{cite journal   |vauthors=Sellick GS, Wade R, Richards S, etal |title=Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis |journal=Blood |volume=111 |issue= 3 |pages= 1625–33 |year= 2008 |pmid= 18006695 |doi= 10.1182/blood-2007-08-110130 |doi-access= free }}
-| citations =
-*{{cite journal  | author=Cho M, Ishida K, Chen J, ''et al.'' |title=SAGE library screening reveals ILT7 as a specific plasmacytoid dendritic cell marker that regulates type I IFN production. |journal=Int. Immunol. |volume=20 |issue= 1 |pages= 155–64 |year= 2008 |pmid= 18048391 |doi= 10.1093/intimm/dxm127 }}
+*{{cite journal  |vauthors=Zhan X, Desiderio DM |title=Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry |journal=Anal. Biochem. |volume=354 |issue= 2 |pages= 279–89 |year= 2006 |pmid= 16777052 |doi= 10.1016/j.ab.2006.05.024 }}
-*{{cite journal  | author=Sellick GS, Wade R, Richards S, ''et al.'' |title=Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis. |journal=Blood |volume=111 |issue= 3 |pages= 1625–33 |year= 2008 |pmid= 18006695 |doi= 10.1182/blood-2007-08-110130 }}
+*{{cite journal   |vauthors=Cao W, Rosen DB, Ito T, etal |title=Plasmacytoid dendritic cell–specific receptor ILT7–FcɛRIγ inhibits Toll-like receptor–induced interferon production |journal=J. Exp. Med. |volume=203 |issue= 6 |pages= 1399–405 |year= 2006 |pmid= 16735691 |doi= 10.1084/jem.20052454  | pmc=2118323 }}
-*{{cite journal  | author=Zhan X, Desiderio DM |title=Nitroproteins from a human pituitary adenoma tissue discovered with a nitrotyrosine affinity column and tandem mass spectrometry. |journal=Anal. Biochem. |volume=354 |issue= 2 |pages= 279–89 |year= 2006 |pmid= 16777052 |doi= 10.1016/j.ab.2006.05.024 }}
+*{{cite journal   |vauthors=Ju XS, Hacker C, Scherer B, etal |title=Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation |journal=Gene |volume=331 |pages= 159–64 |year= 2004 |pmid= 15094202 |doi= 10.1016/j.gene.2004.02.018 }}
-*{{cite journal  | author=Cao W, Rosen DB, Ito T, ''et al.'' |title=Plasmacytoid dendritic cell-specific receptor ILT7-Fc epsilonRI gamma inhibits Toll-like receptor-induced interferon production. |journal=J. Exp. Med. |volume=203 |issue= 6 |pages= 1399–405 |year= 2006 |pmid= 16735691 |doi= 10.1084/jem.20052454 }}
+*{{cite journal   |vauthors=Tedla N, Bandeira-Melo C, Tassinari P, etal |title=Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7 |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 1174–9 |year= 2003 |pmid= 12529506 |doi= 10.1073/pnas.0337567100  | pmc=298746 |bibcode=2003PNAS..100.1174T |doi-access=free }}
-*{{cite journal  | author=Ju XS, Hacker C, Scherer B, ''et al.'' |title=Immunoglobulin-like transcripts ILT2, ILT3 and ILT7 are expressed by human dendritic cells and down-regulated following activation. |journal=Gene |volume=331 |issue=  |pages= 159–64 |year= 2004 |pmid= 15094202 |doi= 10.1016/j.gene.2004.02.018 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M |doi-access=free }}
-*{{cite journal  | author=Tedla N, Bandeira-Melo C, Tassinari P, ''et al.'' |title=Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 1174–9 |year= 2003 |pmid= 12529506 |doi= 10.1073/pnas.0337567100 }}
+*{{cite journal   |vauthors=Rissoan MC, Duhen T, Bridon JM, etal |title=Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells |journal=Blood |volume=100 |issue= 9 |pages= 3295–303 |year= 2002 |pmid= 12384430 |doi= 10.1182/blood-2002-02-0638 |doi-access= free }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Young NT, Canavez F, Uhrberg M, etal |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270–8 |year= 2001 |pmid= 11491530 |doi=10.1007/s002510100332  |s2cid=2819935 }}
-*{{cite journal  | author=Rissoan MC, Duhen T, Bridon JM, ''et al.'' |title=Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells. |journal=Blood |volume=100 |issue= 9 |pages= 3295–303 |year= 2002 |pmid= 12384430 |doi= 10.1182/blood-2002-02-0638 }}
-*{{cite journal  | author=Young NT, Canavez F, Uhrberg M, ''et al.'' |title=Conserved organization of the ILT/LIR gene family within the polymorphic human leukocyte receptor complex. |journal=Immunogenetics |volume=53 |issue= 4 |pages= 270–8 |year= 2001 |pmid= 11491530 |doi=  }}
-*{{cite journal  | author=Wende H, Volz A, Ziegler A |title=Extensive gene duplications and a large inversion characterize the human leukocyte receptor cluster. |journal=Immunogenetics |volume=51 |issue= 8-9 |pages= 703–13 |year= 2000 |pmid= 10941842 |doi=  }}
-}}
 {{refend}}
-{{gene-19-stub}}
+[[Category:Immunoglobulin superfamily]]