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{{Short description|Protein-coding gene in the species Homo sapiens}}
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{{PBB|geneid=92}}
{{Infobox_gene}}


'''Activin receptor type-2A''' is a [[protein]] that in humans is encoded by the ''ACVR2A'' [[gene]].<ref name="pmid1314589">{{cite journal | author = Donaldson CJ, Mathews LS, Vale WW | title = Molecular cloning and binding properties of the human type II activin receptor | journal = Biochem Biophys Res Commun | volume = 184 | issue = 1 | pages = 310–316 |date=May 1992 | pmid = 1314589 | pmc = | doi =10.1016/0006-291X(92)91194-U }}</ref><ref name="pmid10702675">{{cite journal | author = Bondestam J, Horelli-Kuitunen N, Hilden K, Ritvos O, Aaltonen J | title = Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2→q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH | journal = Cytogenet Cell Genet | volume = 87 | issue = 3–4 | pages = 219–220 |date=April 2000 | pmid = 10702675 | pmc = | doi =10.1159/000015429 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ACVR2A activin A receptor, type IIA| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=92| accessdate = }}</ref>
'''Activin receptor type-2A''' is a [[protein]] that in humans is encoded by the ''ACVR2A'' [[gene]].<ref name="pmid1314589">{{cite journal | vauthors = Donaldson CJ, Mathews LS, Vale WW | title = Molecular cloning and binding properties of the human type II activin receptor | journal = Biochem. Biophys. Res. Commun. | volume = 184 | issue = 1 | pages = 310–6 | date = May 1992 | pmid = 1314589 | doi = 10.1016/0006-291X(92)91194-U }}</ref><ref name="pmid10702675">{{cite journal | vauthors = Bondestam J, Horelli-Kuitunen N, Hildén K, Ritvos O, Aaltonen J | title = Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH | journal = Cytogenet. Cell Genet. | volume = 87 | issue = 3–4 | pages = 219–20 | date = April 2000 | pmid = 10702675 | doi = 10.1159/000015429 | s2cid = 36135054 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ACVR2A activin A receptor, type IIA| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=92}}</ref>
ACVR2A is an [[activin type 2 receptor]].
ACVR2A is an [[activin type 2 receptor]].
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
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| summary_text = This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.<ref name="entrez"/>
}}


==Interactions==
== Function ==
ACVR2A has been shown to [[Protein-protein interaction|interact]] with [[INHBA]],<ref name=pmid10746731>{{cite journal |last=Lewis |first=K A |authorlink= |coauthors=Gray P C, Blount A L, MacConell L A, Wiater E, Bilezikjian L M, Vale W |date=March 2000 |title=Betaglycan binds inhibin and can mediate functional antagonism of activin signalling |journal=[[Nature (journal)|Nature]] |volume=404 |issue=6776 |pages=411–414 |publisher= |location = ENGLAND| issn = 0028-0836| pmid = 10746731 |doi = 10.1038/35006129 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid9202237>{{cite journal |last=Martens |first=J W |authorlink= |coauthors=de Winter J P, Timmerman M A, McLuskey A, van Schaik R H, Themmen A P, de Jong F H |date=July 1997 |title=Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells |journal=[[Endocrinology (journal)|Endocrinology]] |volume=138 |issue=7 |pages=2928–2936 |publisher= |location = UNITED STATES| issn = 0013-7227| pmid = 9202237 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1210/en.138.7.2928 }}</ref> [[SYNJ2BP]]<ref name=pmid15451561>{{cite journal |last=Tsuchida |first=Kunihiro |authorlink= |coauthors=Nakatani Masashi, Matsuzaki Takashi, Yamakawa Norio, Liu ZhongHui, Bao YongLi, Arai Koji Y, Murakami Tatsuya, Takehara Yuka, Kurisaki Akira, Sugino Hiromu |date=October 2004 |title=Novel factors in regulation of activin signaling |journal=Mol. Cell. Endocrinol. |volume=225 |issue=1–2 |pages=1–8 |publisher= |location = Ireland| issn = 0303-7207| pmid = 15451561 |doi = 10.1016/j.mce.2004.02.006 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref><ref name=pmid11882656>{{cite journal |last=Matsuzaki |first=Takashi |authorlink= |coauthors=Hanai Sayuri, Kishi Hisashi, Liu ZhongHui, Bao YongLi, Kikuchi Akira, Tsuchida Kunihiro, Sugino Hiromu |date=May 2002 |title=Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway |journal=J. Biol. Chem. |volume=277 |issue=21 |pages=19008–19018 |publisher= |location = United States| issn = 0021-9258| pmid = 11882656 |doi = 10.1074/jbc.M112472200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[ACVR1B]].<ref name=pmid9892009>{{cite journal |last=Lebrun |first=J J |authorlink= |coauthors=Takabe K, Chen Y, Vale W |date=January 1999 |title=Roles of pathway-specific and inhibitory Smads in activin receptor signaling |journal=Mol. Endocrinol. |volume=13 |issue=1 |pages=15–23 |publisher= |location = UNITED STATES| issn = 0888-8809| pmid = 9892009 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1210/me.13.1.15 }}</ref><ref name=pmid8612709>{{cite journal |last=De Winter |first=J P |authorlink= |coauthors=De Vries C J, Van Achterberg T A, Ameerun R F, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij A J |date=May 1996 |title=Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors |journal=Exp. Cell Res. |volume=224 |issue=2 |pages=323–334 |publisher= |location = UNITED STATES| issn = 0014-4827| pmid = 8612709 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1006/excr.1996.0142 }}</ref>


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This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the [[transforming growth factor-beta]] (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of [[receptor protein serine/threonine kinase|receptor serine kinases]] which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with [[cysteine]]-rich region, a [[transmembrane domain]], and a [[cytoplasmic]] domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in [[phosphorylation]] of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.<ref name="entrez"/>
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==References==

== Interactions ==

ACVR2A has been shown to [[Protein-protein interaction|interact]] with:
* [[ACVR1B]],<ref name = pmid9892009>{{cite journal | vauthors = Lebrun JJ, Takabe K, Chen Y, Vale W | title = Roles of pathway-specific and inhibitory Smads in activin receptor signaling | journal = Mol. Endocrinol. | volume = 13 | issue = 1 | pages = 15–23 | date = January 1999 | pmid = 9892009 | doi = 10.1210/mend.13.1.0218 | s2cid = 26825706 | doi-access = free }}</ref><ref name = pmid8612709>{{cite journal | vauthors = De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ | title = Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors | journal = Exp. Cell Res. | volume = 224 | issue = 2 | pages = 323–34 | date = May 1996 | pmid = 8612709 | doi = 10.1006/excr.1996.0142 }}</ref>
* [[INHBA]],<ref name = pmid10746731>{{cite journal | vauthors = Lewis KA, Gray PC, Blount AL, MacConell LA, Wiater E, Bilezikjian LM, Vale W | title = Betaglycan binds inhibin and can mediate functional antagonism of activin signalling | journal = Nature | volume = 404 | issue = 6776 | pages = 411–4 | date = March 2000 | pmid = 10746731 | doi = 10.1038/35006129 | bibcode = 2000Natur.404..411L | s2cid = 4393629 }}</ref><ref name = pmid9202237>{{cite journal | vauthors = Martens JW, de Winter JP, Timmerman MA, McLuskey A, van Schaik RH, Themmen AP, de Jong FH | title = Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells | journal = Endocrinology | volume = 138 | issue = 7 | pages = 2928–36 | date = July 1997 | pmid = 9202237 | doi = 10.1210/endo.138.7.5250 | doi-access = free }}</ref> and
* [[SYNJ2BP]].<ref name = pmid15451561>{{cite journal | vauthors = Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H | title = Novel factors in regulation of activin signaling | journal = Mol. Cell. Endocrinol. | volume = 225 | issue = 1–2 | pages = 1–8 | date = October 2004 | pmid = 15451561 | doi = 10.1016/j.mce.2004.02.006 | s2cid = 34666659 }}</ref><ref name = pmid11882656>{{cite journal | vauthors = Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H | title = Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway | journal = J. Biol. Chem. | volume = 277 | issue = 21 | pages = 19008–18 | date = May 2002 | pmid = 11882656 | doi = 10.1074/jbc.M112472200 | doi-access = free }}</ref>

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== References ==
{{reflist}}
{{reflist}}


==Further reading==
==External links==
* {{UCSC gene info|ACVR2A}}

== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Welt CK | title = The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction | journal = Curr. Opin. Obstet. Gynecol. | volume = 14 | issue = 3 | pages = 317–23 | year = 2002 | pmid = 12032389 | doi = 10.1097/00001703-200206000-00012 | s2cid = 44327401 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Matzuk MM, Bradley A | title = Cloning of the human activin receptor cDNA reveals high evolutionary conservation | journal = Biochim. Biophys. Acta | volume = 1130 | issue = 1 | pages = 105–8 | year = 1992 | pmid = 1311955 | doi = 10.1016/0167-4781(92)90472-C }}
| citations =
*{{cite journal | author=Welt CK |title=The physiology and pathophysiology of inhibin, activin and follistatin in female reproduction |journal=Curr. Opin. Obstet. Gynecol. |volume=14 |issue= 3 |pages= 317–323 |year= 2002 |pmid= 12032389 |doi=10.1097/00001703-200206000-00012 }}
* {{cite journal | vauthors = Mathews LS, Vale WW | title = Expression cloning of an activin receptor, a predicted transmembrane serine kinase | journal = Cell | volume = 65 | issue = 6 | pages = 973–82 | year = 1991 | pmid = 1646080 | doi = 10.1016/0092-8674(91)90549-E | s2cid = 36407277 }}
*{{cite journal | author=Matzuk MM, Bradley A |title=Cloning of the human activin receptor cDNA reveals high evolutionary conservation |journal=Biochim. Biophys. Acta |volume=1130 |issue= 1 |pages= 105–8 |year= 1992 |pmid= 1311955 |doi= 10.1016/0167-4781(92)90472-C}}
* {{cite journal | vauthors = Xu J, McKeehan K, Matsuzaki K, McKeehan WL | title = Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism | journal = J. Biol. Chem. | volume = 270 | issue = 11 | pages = 6308–13 | year = 1995 | pmid = 7890768 | doi = 10.1074/jbc.270.11.6308 | doi-access = free }}
*{{cite journal | author=Mathews LS, Vale WW |title=Expression cloning of an activin receptor, a predicted transmembrane serine kinase |journal=Cell |volume=65 |issue= 6 |pages= 973–982 |year= 1991 |pmid= 1646080 |doi=10.1016/0092-8674(91)90549-E }}
* {{cite journal | vauthors = Attisano L, Cárcamo J, Ventura F, Weis FM, Massagué J, Wrana JL | title = Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors | journal = Cell | volume = 75 | issue = 4 | pages = 671–80 | year = 1993 | pmid = 8242742 | doi = 10.1016/0092-8674(93)90488-C | s2cid = 25408172 }}
*{{cite journal | author=Xu J, McKeehan K, Matsuzaki K, McKeehan WL |title=Inhibin antagonizes inhibition of liver cell growth by activin by a dominant-negative mechanism |journal=J. Biol. Chem. |volume=270 |issue= 11 |pages= 6308–6313 |year= 1995 |pmid= 7890768 |doi=10.1074/jbc.270.11.6308 }}
* {{cite journal | vauthors = Peng C, Huang TH, Jeung EB, Donaldson CJ, Vale WW, Leung PC | title = Expression of the type II activin receptor gene in the human placenta | journal = Endocrinology | volume = 133 | issue = 6 | pages = 3046–9 | year = 1993 | pmid = 8243335 | doi = 10.1210/endo.133.6.8243335 }}
* {{cite journal | vauthors = De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ | title = Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors | journal = Exp. Cell Res. | volume = 224 | issue = 2 | pages = 323–34 | year = 1996 | pmid = 8612709 | doi = 10.1006/excr.1996.0142 }}
*{{cite journal | author=Attisano L |title=Identification of human activin and TGF beta type I receptors that form heteromeric kinase complexes with type II receptors |journal=Cell |volume=75 |issue= 4 |pages= 671–680 |year= 1993 |pmid= 8242742 |doi=10.1016/0092-8674(93)90488-C | author-separator=, | author2=Cárcamo J | author3=Ventura F | display-authors=3 | last4=Weis | first4=FM | last5=Massagué | first5=J | last6=Wrana | first6=JL }}
* {{cite journal | vauthors = Attisano L, Wrana JL, Montalvo E, Massagué J | title = Activation of signalling by the activin receptor complex | journal = Mol. Cell. Biol. | volume = 16 | issue = 3 | pages = 1066–73 | year = 1996 | pmid = 8622651 | pmc = 231089 | doi = 10.1128/mcb.16.3.1066}}
*{{cite journal | author=Peng C |title=Expression of the type II activin receptor gene in the human placenta |journal=Endocrinology |volume=133 |issue= 6 |pages= 3046–3049 |year= 1994 |pmid= 8243335 |doi=10.1210/en.133.6.3046 | author-separator=, | author2=Huang TH | author3=Jeung EB | display-authors=3 | last4=Donaldson | first4=CJ | last5=Vale | first5=WW | last6=Leung | first6=PC }}
* {{cite journal | vauthors = Liu QY, Niranjan B, Gomes P, Gomm JJ, Davies D, Coombes RC, Buluwela L | title = Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells | journal = Cancer Res. | volume = 56 | issue = 5 | pages = 1155–63 | year = 1996 | pmid = 8640777 }}
*{{cite journal | author=De Winter JP |title=Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors |journal=Exp. Cell Res. |volume=224 |issue= 2 |pages= 323–334 |year= 1996 |pmid= 8612709 |doi=10.1006/excr.1996.0142 | author-separator=, | author2=De Vries CJ | author3=Van Achterberg TA | display-authors=3 | last4=Ameerun | first4=R | last5=Feijen | first5=A | last6=Sugino | first6=H | last7=Dewaele | first7=P | last8=Huylebroeck | first8=D | last9=Verschueren | first9=K }}
*{{cite journal | author=Attisano L, Wrana JL, Montalvo E, Massagué J |title=Activation of signalling by the activin receptor complex |journal=Mol. Cell. Biol. |volume=16 |issue= 3 |pages= 1066–73 |year= 1996 |pmid= 8622651 |doi= | pmc=231089 }}
* {{cite journal | vauthors = Nishitoh H, Ichijo H, Kimura M, Matsumoto T, Makishima F, Yamaguchi A, Yamashita H, Enomoto S, Miyazono K | title = Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5 | journal = J. Biol. Chem. | volume = 271 | issue = 35 | pages = 21345–52 | year = 1996 | pmid = 8702914 | doi = 10.1074/jbc.271.35.21345 | doi-access = free }}
* {{cite journal | vauthors = Lebrun JJ, Vale WW | title = Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation | journal = Mol. Cell. Biol. | volume = 17 | issue = 3 | pages = 1682–91 | year = 1997 | pmid = 9032295 | pmc = 231893 | doi = 10.1128/mcb.17.3.1682}}
*{{cite journal | author=Liu QY |title=Inhibitory effects of activin on the growth and morpholgenesis of primary and transformed mammary epithelial cells |journal=Cancer Res. |volume=56 |issue= 5 |pages= 1155–63 |year= 1996 |pmid= 8640777 |doi= | author-separator=, | author2=Niranjan B | author3=Gomes P | display-authors=3 | last4=Gomm | first4=JJ | last5=Davies | first5=D | last6=Coombes | first6=RC | last7=Buluwela | first7=L }}
* {{cite journal | vauthors = Macías-Silva M, Hoodless PA, Tang SJ, Buchwald M, Wrana JL | title = Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2 | journal = J. Biol. Chem. | volume = 273 | issue = 40 | pages = 25628–36 | year = 1998 | pmid = 9748228 | doi = 10.1074/jbc.273.40.25628 | doi-access = free }}
*{{cite journal | author=Nishitoh H |title=Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5 |journal=J. Biol. Chem. |volume=271 |issue= 35 |pages= 21345–21352 |year= 1996 |pmid= 8702914 |doi=10.1074/jbc.271.35.21345 | author-separator=, | author2=Ichijo H | author3=Kimura M | display-authors=3 | last4=Matsumoto | first4=T | last5=Makishima | first5=F | last6=Yamaguchi | first6=A | last7=Yamashita | first7=H | last8=Enomoto | first8=S | last9=Miyazono | first9=K }}
*{{cite journal | author=Lebrun JJ, Vale WW |title=Activin and inhibin have antagonistic effects on ligand-dependent heteromerization of the type I and type II activin receptors and human erythroid differentiation |journal=Mol. Cell. Biol. |volume=17 |issue= 3 |pages= 1682–91 |year= 1997 |pmid= 9032295 |doi= | pmc=231893 }}
* {{cite journal | vauthors = Barbara NP, Wrana JL, Letarte M | title = Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily | journal = J. Biol. Chem. | volume = 274 | issue = 2 | pages = 584–94 | year = 1999 | pmid = 9872992 | doi = 10.1074/jbc.274.2.584 | doi-access = free }}
*{{cite journal | author=Macías-Silva M |title=Specific activation of Smad1 signaling pathways by the BMP7 type I receptor, ALK2 |journal=J. Biol. Chem. |volume=273 |issue= 40 |pages= 25628–25636 |year= 1998 |pmid= 9748228 |doi=10.1074/jbc.273.40.25628 | author-separator=, | author2=Hoodless PA | author3=Tang SJ | display-authors=3 | last4=Buchwald | first4=M | last5=Wrana | first5=JL }}
* {{cite journal | vauthors = Lux A, Attisano L, Marchuk DA | title = Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1 | journal = J. Biol. Chem. | volume = 274 | issue = 15 | pages = 9984–92 | year = 1999 | pmid = 10187774 | doi = 10.1074/jbc.274.15.9984 | doi-access = free }}
*{{cite journal | author=Barbara NP, Wrana JL, Letarte M |title=Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily |journal=J. Biol. Chem. |volume=274 |issue= 2 |pages= 584–594 |year= 1999 |pmid= 9872992 |doi=10.1074/jbc.274.2.584 }}
* {{cite journal | vauthors = D'Abronzo FH, Swearingen B, Klibanski A, Alexander JM | title = Mutational analysis of activin/transforming growth factor-beta type I and type II receptor kinases in human pituitary tumors | journal = J. Clin. Endocrinol. Metab. | volume = 84 | issue = 5 | pages = 1716–21 | year = 1999 | doi = 10.1210/jcem.84.5.5704 | pmid = 10323406 }}
*{{cite journal | author=Lux A, Attisano L, Marchuk DA |title=Assignment of transforming growth factor beta1 and beta3 and a third new ligand to the type I receptor ALK-1 |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 9984–9992 |year= 1999 |pmid= 10187774 |doi=10.1074/jbc.274.15.9984 }}
* {{cite journal | vauthors = Ebisawa T, Tada K, Kitajima I, Tojo K, Sampath TK, Kawabata M, Miyazono K, Imamura T | title = Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation | journal = J. Cell Sci. | volume = 112 | issue = 20 | pages = 3519–27 | year = 1999 | doi = 10.1242/jcs.112.20.3519 | pmid = 10504300 }}
*{{cite journal | author=D'Abronzo FH, Swearingen B, Klibanski A, Alexander JM |title=Mutational analysis of activin/transforming growth factor-beta type I and type II receptor kinases in human pituitary tumors |journal=J. Clin. Endocrinol. Metab. |volume=84 |issue= 5 |pages= 1716–1721 |year= 1999 |pmid= 10323406 |doi=10.1210/jc.84.5.1716 }}
* {{cite journal | vauthors = van Schaik RH, Wierikx CD, Timmerman MA, Oomen MH, van Weerden WM, van der Kwast TH, van Steenbrugge GJ, de Jong FH | title = Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues | journal = Br. J. Cancer | volume = 82 | issue = 1 | pages = 112–7 | year = 2000 | pmid = 10638976 | pmc = 2363208 | doi = 10.1054/bjoc.1999.0886 }}
⚫
* {{cite journal | vauthors = Shoji H, Tsuchida K, Kishi H, Yamakawa N, Matsuzaki T, Liu Z, Nakamura T, Sugino H | title = Identification and characterization of a PDZ protein that interacts with activin type II receptors | journal = J. Biol. Chem. | volume = 275 | issue = 8 | pages = 5485–92 | year = 2000 | pmid = 10681527 | doi = 10.1074/jbc.275.8.5485 | doi-access = free }}
*{{cite journal | author=Ebisawa T |title=Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation |journal=J. Cell. Sci. |volume=112 |issue= 20|pages= 3519–27 |year= 2000 |pmid= 10504300 |doi= | author-separator=, | author2=Tada K | author3=Kitajima I | display-authors=3 | last4=Tojo | first4=K | last5=Sampath | first5=TK | last6=Kawabata | first6=M | last7=Miyazono | first7=K | last8=Imamura | first8=T }}
*{{cite journal | author=van Schaik RH |title=Variations in activin receptor, inhibin/activin subunit and follistatin mRNAs in human prostate tumour tissues |journal=Br. J. Cancer |volume=82 |issue= 1 |pages= 112–117 |year= 2000 |pmid= 10638976 |doi= 10.1054/bjoc.1999.0886 | pmc=2363208 | author-separator=, | author2=Wierikx CD | author3=Timmerman MA | display-authors=3 | last4=Oomen | first4=MH | last5=Van Weerden | first5=WM | last6=Van Der Kwast | first6=TH | last7=Van Steenbrugge | first7=GJ | last8=De Jong | first8=FH }}
⚫
*{{cite journal | author=Shoji H |title=Identification and characterization of a PDZ protein that interacts with activin type II receptors |journal=J. Biol. Chem. |volume=275 |issue= 8 |pages= 5485–5492 |year= 2000 |pmid= 10681527 |doi=10.1074/jbc.275.8.5485 | author-separator=, | author2=Tsuchida K | author3=Kishi H | display-authors=3 | last4=Yamakawa | first4=N | last5=Matsuzaki | first5=T | last6=Liu | first6=Z | last7=Nakamura | first7=T | last8=Sugino | first8=H }}
}}
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Latest revision as of 20:41, 13 August 2023

ACVR2A
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesACVR2A, ACTRII, ACVR2, activin A receptor type 2A
External IDsOMIM: 102581; MGI: 102806; HomoloGene: 20391; GeneCards: ACVR2A; OMA:ACVR2A - orthologs
Orthologs
SpeciesHumanMouse
Entrez

92

11480

Ensembl

ENSG00000121989

ENSMUSG00000052155

UniProt

P27037

P27038

RefSeq (mRNA)

NM_001278579
NM_001278580
NM_001616

NM_007396

RefSeq (protein)

NP_001265508
NP_001265509
NP_001607

NP_031422

Location (UCSC)Chr 2: 147.84 – 147.93 MbChr 2: 48.7 – 48.79 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Activin receptor type-2A is a protein that in humans is encoded by the ACVR2A gene.[5][6][7] ACVR2A is an activin type 2 receptor.

Function

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This gene encodes activin A type II receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases.[7]

Interactions

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ACVR2A has been shown to interact with:

References

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  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000121989 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000052155 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Donaldson CJ, Mathews LS, Vale WW (May 1992). "Molecular cloning and binding properties of the human type II activin receptor". Biochem. Biophys. Res. Commun. 184 (1): 310–6. doi:10.1016/0006-291X(92)91194-U. PMID 1314589.
  6. ^ Bondestam J, Horelli-Kuitunen N, Hildén K, Ritvos O, Aaltonen J (April 2000). "Assignment of ACVR2 and ACVR2B the human activin receptor type II and IIB genes to chromosome bands 2q22.2-->q23.3 and 3p22 and the human follistatin gene (FST) to chromosome 5q11.2 by FISH". Cytogenet. Cell Genet. 87 (3–4): 219–20. doi:10.1159/000015429. PMID 10702675. S2CID 36135054.
  7. ^ a b "Entrez Gene: ACVR2A activin A receptor, type IIA".
  8. ^ Lebrun JJ, Takabe K, Chen Y, Vale W (January 1999). "Roles of pathway-specific and inhibitory Smads in activin receptor signaling". Mol. Endocrinol. 13 (1): 15–23. doi:10.1210/mend.13.1.0218. PMID 9892009. S2CID 26825706.
  9. ^ De Winter JP, De Vries CJ, Van Achterberg TA, Ameerun RF, Feijen A, Sugino H, De Waele P, Huylebroeck D, Verschueren K, Van Den Eijden-Van Raaij AJ (May 1996). "Truncated activin type II receptors inhibit bioactivity by the formation of heteromeric complexes with activin type I. receptors". Exp. Cell Res. 224 (2): 323–34. doi:10.1006/excr.1996.0142. PMID 8612709.
  10. ^ Lewis KA, Gray PC, Blount AL, MacConell LA, Wiater E, Bilezikjian LM, Vale W (March 2000). "Betaglycan binds inhibin and can mediate functional antagonism of activin signalling". Nature. 404 (6776): 411–4. Bibcode:2000Natur.404..411L. doi:10.1038/35006129. PMID 10746731. S2CID 4393629.
  11. ^ Martens JW, de Winter JP, Timmerman MA, McLuskey A, van Schaik RH, Themmen AP, de Jong FH (July 1997). "Inhibin interferes with activin signaling at the level of the activin receptor complex in Chinese hamster ovary cells". Endocrinology. 138 (7): 2928–36. doi:10.1210/endo.138.7.5250. PMID 9202237.
  12. ^ Tsuchida K, Nakatani M, Matsuzaki T, Yamakawa N, Liu Z, Bao Y, Arai KY, Murakami T, Takehara Y, Kurisaki A, Sugino H (October 2004). "Novel factors in regulation of activin signaling". Mol. Cell. Endocrinol. 225 (1–2): 1–8. doi:10.1016/j.mce.2004.02.006. PMID 15451561. S2CID 34666659.
  13. ^ Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H (May 2002). "Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway". J. Biol. Chem. 277 (21): 19008–18. doi:10.1074/jbc.M112472200. PMID 11882656.
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Further reading

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