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{{Short description|Protein-coding gene in the species Homo sapiens}}
{{PBB|geneid=6891}}
{{Infobox_gene}}
'''TAP2''' is a [[gene]] in humans that encodes the [[protein]] '''Antigen peptide transporter 2'''.<ref name="pmid1529427">{{cite journal | author = Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T, et al. | title = Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system | journal = Tissue Antigens | volume = 39 | issue = 4 | pages = 161–73 | year = 1992 | month = Oct | pmid = 1529427 | pmc = | doi = }}</ref><ref name="pmid1946428">{{cite journal | author = Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T | title = Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 22 | pages = 10094–8 | year = 1991 | month = Dec | pmid = 1946428 | pmc = 52874 | doi = }}</ref><ref name="pmid16395595">{{cite journal | author = Hahn Y, Lee B | title = Human-specific nonsense mutations identified by genome sequence comparisons | journal = Hum Genet | volume = 119 | issue = 1-2 | pages = 169–78 | year = 2006 | month = Feb | pmid = 16395595 | pmc = | doi = 10.1007/s00439-005-0125-6 }}</ref>
'''TAP2''' is a [[gene]] in humans that encodes the [[protein]] '''Antigen peptide transporter 2'''.<ref name="pmid1529427">{{cite journal | vauthors = Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T | title = Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system | journal = Tissue Antigens | volume = 39 | issue = 4 | pages = 161–73 | date = Oct 1992 | pmid = 1529427 | doi = 10.1111/j.1399-0039.1992.tb01932.x | doi-access = free }}</ref><ref name="pmid1946428">{{cite journal | vauthors = Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T | title = Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region | journal = Proc Natl Acad Sci U S A | volume = 88 | issue = 22 | pages = 10094–8 | date = Dec 1991 | pmid = 1946428 | pmc = 52874 | doi = 10.1073/pnas.88.22.10094 | bibcode = 1991PNAS...8810094B | doi-access = free }}</ref><ref name="pmid16395595">{{cite journal | vauthors = Hahn Y, Lee B | title = Human-specific nonsense mutations identified by genome sequence comparisons | journal = Hum Genet | volume = 119 | issue = 1–2 | pages = 169–78 | date = Feb 2006 | pmid = 16395595 | doi = 10.1007/s00439-005-0125-6 | s2cid = 21059468 | url = https://zenodo.org/record/1232721 }}</ref>


== Function ==
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
| section_title =
⚫
| summary_text = The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various [[molecule]]s across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2. The protein encoded by this gene is involved in [[antigen presentation]]. This protein forms a heterodimer with ABCB2 in order to transport peptides from the [[cytoplasm]] to the [[endoplasmic reticulum]]. Mutations in this gene may be associated with [[ankylosing spondylitis]], insulin-dependent [[diabetes mellitus]], and [[celiac disease]]. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.<ref>{{cite web | title = Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6891| accessdate = }}</ref>
}}


⚫
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various [[molecule]]s across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2 ([[TAP1]]). The protein encoded by this gene is involved in [[antigen presentation]]. This protein forms a heterodimer with ABCB2 in order to transport peptides from the [[cytoplasm]] to the [[endoplasmic reticulum]]. Mutations in this gene may be associated with [[ankylosing spondylitis]], insulin-dependent [[diabetes mellitus]], [[schizophrenia]],<ref>{{cite journal | vauthors = Yu H | title = Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population. | journal = Journal of Psychiatric Research | year = 2014 | volume = 50 | pages = 73–8 | doi = 10.1016/j.jpsychires.2013.11.014 | pmid = 24365204 }}</ref> and [[celiac disease]]. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.<ref>{{cite web | title = Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6891}}</ref>
⚫
==See also==

⚫
== See also ==
* [[ATP-binding cassette transporter]]
* [[ATP-binding cassette transporter]]


==References==
== References ==
{{reflist}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
* {{cite journal | vauthors = Townsend A, Trowsdale J | title = The transporters associated with antigen presentation | journal = Semin. Cell Biol. | volume = 4 | issue = 1 | pages = 53–61 | year = 1993 | pmid = 8453065 | doi = 10.1006/scel.1993.1007 }}
{{PBB_Further_reading
* {{cite journal | vauthors = Beck S, Kelly A, Radley E, Khurshid F, Alderton RP, Trowsdale J | title = DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing | journal = J. Mol. Biol. | volume = 228 | issue = 2 | pages = 433–41 | year = 1992 | pmid = 1453454 | doi = 10.1016/0022-2836(92)90832-5 }}
| citations =
*{{cite journal | author=Townsend A, Trowsdale J |title=The transporters associated with antigen presentation. |journal=Semin. Cell Biol. |volume=4 |issue= 1 |pages= 53–61 |year= 1993 |pmid= 8453065 |doi=10.1006/scel.1993.1007 }}
* {{cite journal | vauthors = Kelly A, Powis SH, Kerr LA, Mockridge I, Elliott T, Bastin J, Uchanska-Ziegler B, Ziegler A, Trowsdale J, Townsend A | title = Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex | journal = Nature | volume = 355 | issue = 6361 | pages = 641–4 | year = 1992 | pmid = 1538751 | doi = 10.1038/355641a0 | bibcode = 1992Natur.355..641K | s2cid = 32569414 | doi-access = free }}
*{{cite journal | author=Beck S, Kelly A, Radley E, ''et al.'' |title=DNA sequence analysis of 66 kb of the human MHC class II region encoding a cluster of genes for antigen processing. |journal=J. Mol. Biol. |volume=228 |issue= 2 |pages= 433–41 |year= 1992 |pmid= 1453454 |doi=10.1016/0022-2836(92)90832-5 }}
* {{cite journal | vauthors = Colonna M, Bresnahan M, Bahram S, Strominger JL, Spies T | title = Allelic variants of the human putative peptide transporter involved in antigen processing | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 9 | pages = 3932–6 | year = 1992 | pmid = 1570316 | pmc = 525605 | doi = 10.1073/pnas.89.9.3932 | bibcode = 1992PNAS...89.3932C | doi-access = free }}
*{{cite journal | author=Kelly A, Powis SH, Kerr LA, ''et al.'' |title=Assembly and function of the two ABC transporter proteins encoded in the human major histocompatibility complex. |journal=Nature |volume=355 |issue= 6361 |pages= 641–4 |year= 1992 |pmid= 1538751 |doi= 10.1038/355641a0 }}
* {{cite journal | vauthors = Powis SH, Mockridge I, Kelly A, Kerr LA, Glynne R, Gileadi U, Beck S, Trowsdale J | title = Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 89 | issue = 4 | pages = 1463–7 | year = 1992 | pmid = 1741401 | pmc = 48471 | doi = 10.1073/pnas.89.4.1463 | bibcode = 1992PNAS...89.1463P | doi-access = free }}
*{{cite journal | author=Colonna M, Bresnahan M, Bahram S, ''et al.'' |title=Allelic variants of the human putative peptide transporter involved in antigen processing. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 9 |pages= 3932–6 |year= 1992 |pmid= 1570316 |doi=10.1073/pnas.89.9.3932 }}
* {{cite journal | vauthors = Trowsdale J, Hanson I, Mockridge I, Beck S, Townsend A, Kelly A | title = Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters | journal = Nature | volume = 348 | issue = 6303 | pages = 741–4 | year = 1991 | pmid = 2259383 | doi = 10.1038/348741a0 | s2cid = 4279033 }}
*{{cite journal | author=Powis SH, Mockridge I, Kelly A, ''et al.'' |title=Polymorphism in a second ABC transporter gene located within the class II region of the human major histocompatibility complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 4 |pages= 1463–7 |year= 1992 |pmid= 1741401 |doi=10.1073/pnas.89.4.1463 }}
* {{cite journal | vauthors = de la Salle H, Hanau D, Fricker D, Urlacher A, Kelly A, Salamero J, Powis SH, Donato L, Bausinger H, Laforet M | title = Homozygous human TAP peptide transporter mutation in HLA class I deficiency | journal = Science | volume = 265 | issue = 5169 | pages = 237–41 | year = 1994 | pmid = 7517574 | doi = 10.1126/science.7517574 | bibcode = 1994Sci...265..237D }}
*{{cite journal | author=Trowsdale J, Hanson I, Mockridge I, ''et al.'' |title=Sequences encoded in the class II region of the MHC related to the 'ABC' superfamily of transporters. |journal=Nature |volume=348 |issue= 6303 |pages= 741–4 |year= 1991 |pmid= 2259383 |doi= 10.1038/348741a0 }}
* {{cite journal | vauthors = Cano P, Baxter-Lowe LA | title = Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain | journal = Tissue Antigens | volume = 45 | issue = 2 | pages = 139–42 | year = 1995 | pmid = 7792761 | doi = 10.1111/j.1399-0039.1995.tb02431.x }}
*{{cite journal | author=de la Salle H, Hanau D, Fricker D, ''et al.'' |title=Homozygous human TAP peptide transporter mutation in HLA class I deficiency. |journal=Science |volume=265 |issue= 5169 |pages= 237–41 |year= 1994 |pmid= 7517574 |doi=10.1126/science.7517574 }}
* {{cite journal | vauthors = Roby KF, Fei K, Yang Y, Hunt JS | title = Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines | journal = Immunology | volume = 83 | issue = 3 | pages = 444–8 | year = 1995 | pmid = 7835969 | pmc = 1415039 }}
*{{cite journal | author=Cano P, Baxter-Lowe LA |title=Novel human TAP2*103 allele shows further polymorphism in the ATP-binding domain. |journal=Tissue Antigens |volume=45 |issue= 2 |pages= 139–42 |year= 1995 |pmid= 7792761 |doi=10.1111/j.1399-0039.1995.tb02431.x }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Roby KF, Fei K, Yang Y, Hunt JS |title=Expression of HLA class II-associated peptide transporter and proteasome genes in human placentas and trophoblast cell lines. |journal=Immunology |volume=83 |issue= 3 |pages= 444–8 |year= 1995 |pmid= 7835969 |doi= }}
* {{cite journal | vauthors = Singal DP, Ye M, Qiu X, D'Souza M | title = Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis | journal = Clin. Exp. Rheumatol. | volume = 12 | issue = 1 | pages = 29–33 | year = 1994 | pmid = 8162639 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Powis SH, Tonks S, Mockridge I, Kelly AP, Bodmer JG, Trowsdale J | title = Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2 | journal = Immunogenetics | volume = 37 | issue = 5 | pages = 373–80 | year = 1993 | pmid = 8428770 | doi = 10.1007/BF00216802 | s2cid = 35123181 }}
*{{cite journal | author=Singal DP, Ye M, Qiu X, D'Souza M |title=Polymorphisms in the TAP2 gene and their association with rheumatoid arthritis. |journal=Clin. Exp. Rheumatol. |volume=12 |issue= 1 |pages= 29–33 |year= 1994 |pmid= 8162639 |doi= }}
* {{cite journal | vauthors = Glynne R, Kerr LA, Mockridge I, Beck S, Kelly A, Trowsdale J | title = The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing | journal = Eur. J. Immunol. | volume = 23 | issue = 4 | pages = 860–6 | year = 1993 | pmid = 8458375 | doi = 10.1002/eji.1830230414 | s2cid = 44733094 }}
*{{cite journal | author=Powis SH, Tonks S, Mockridge I, ''et al.'' |title=Alleles and haplotypes of the MHC-encoded ABC transporters TAP1 and TAP2. |journal=Immunogenetics |volume=37 |issue= 5 |pages= 373–80 |year= 1993 |pmid= 8428770 |doi=10.1007/BF00216802 }}
* {{cite journal | vauthors = Beck S, Abdulla S, Alderton RP, Glynne RJ, Gut IG, Hosking LK, Jackson A, Kelly A, Newell WR, Sanseau P, Radley E, Thorpe KL, Trowsdale J | title = Evolutionary dynamics of non-coding sequences within the class II region of the human MHC | journal = J. Mol. Biol. | volume = 255 | issue = 1 | pages = 1–13 | year = 1996 | pmid = 8568858 | doi = 10.1006/jmbi.1996.0001 }}
*{{cite journal | author=Glynne R, Kerr LA, Mockridge I, ''et al.'' |title=The major histocompatibility complex-encoded proteasome component LMP7: alternative first exons and post-translational processing. |journal=Eur. J. Immunol. |volume=23 |issue= 4 |pages= 860–6 |year= 1993 |pmid= 8458375 |doi=10.1002/eji.1830230414 }}
* {{cite journal | vauthors = Ahn K, Meyer TH, Uebel S, Sempé P, Djaballah H, Yang Y, Peterson PA, Früh K, Tampé R | title = Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47 | journal = EMBO J. | volume = 15 | issue = 13 | pages = 3247–55 | year = 1996 | pmid = 8670825 | pmc = 451885 | doi = 10.1002/j.1460-2075.1996.tb00689.x}}
*{{cite journal | author=Beck S, Abdulla S, Alderton RP, ''et al.'' |title=Evolutionary dynamics of non-coding sequences within the class II region of the human MHC. |journal=J. Mol. Biol. |volume=255 |issue= 1 |pages= 1–13 |year= 1996 |pmid= 8568858 |doi= 10.1006/jmbi.1996.0001 }}
* {{cite journal | vauthors = Pattanakitsakul S, Takeuchi F, Nabeta H, Nakano K, Kuwata S, Yanagisawa M, Shibata Y, Ito K | title = A novel TAP 2 gene RFLP observed in a Japanese | journal = Tissue Antigens | volume = 47 | issue = 4 | pages = 353–5 | year = 1996 | pmid = 8773329 | doi = 10.1111/j.1399-0039.1996.tb02567.x }}
*{{cite journal | author=Ahn K, Meyer TH, Uebel S, ''et al.'' |title=Molecular mechanism and species specificity of TAP inhibition by herpes simplex virus ICP47. |journal=Embo J. |volume=15 |issue= 13 |pages= 3247–55 |year= 1996 |pmid= 8670825 |doi= }}
* {{cite journal | vauthors = Lewis JW, Neisig A, Neefjes J, Elliott T | title = Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP | journal = Curr. Biol. | volume = 6 | issue = 7 | pages = 873–83 | year = 1997 | pmid = 8805302 | doi = 10.1016/S0960-9822(02)00611-5 | doi-access = free }}
*{{cite journal | author=Pattanakitsakul S, Takeuchi F, Nabeta H, ''et al.'' |title=A novel TAP 2 gene RFLP observed in a Japanese. |journal=Tissue Antigens |volume=47 |issue= 4 |pages= 353–5 |year= 1996 |pmid= 8773329 |doi=10.1111/j.1399-0039.1996.tb02567.x }}
*{{cite journal | author=Lewis JW, Neisig A, Neefjes J, Elliott T |title=Point mutations in the alpha 2 domain of HLA-A2.1 define a functionally relevant interaction with TAP. |journal=Curr. Biol. |volume=6 |issue= 7 |pages= 873–83 |year= 1997 |pmid= 8805302 |doi=10.1016/S0960-9822(02)00611-5 }}
}}
{{refend}}
{{refend}}


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* {{MeshName|TAP2+protein,+human}}
* {{MeshName|TAP2+protein,+human}}


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{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
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{{ABC transporters}}
{{Membrane transport proteins}}
⚫
[[Category:ABC transporters]]


[[Category:ATP-binding cassette transporters]]
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Latest revision as of 19:32, 12 August 2023

TAP2
Identifiers
AliasesTAP2, ABC18, ABCB3, APT2, D6S217E, PSF-2, PSF2, RING11, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP), transporter 2, ATP binding cassette subfamily B member
External IDsOMIM: 170261; MGI: 98484; HomoloGene: 37323; GeneCards: TAP2; OMA:TAP2 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

6891

21355

Ensembl

ENSMUSG00000024339

UniProt

Q03519

P36371

RefSeq (mRNA)

NM_018833
NM_000544
NM_001290043

NM_011530

RefSeq (protein)

NP_000535
NP_001276972
NP_061313

NP_035660

Location (UCSC)Chr 6: 32.82 – 32.84 MbChr 17: 34.42 – 34.44 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

TAP2 is a gene in humans that encodes the protein Antigen peptide transporter 2.[5][6][7]

Function

[edit]

The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. This gene is located 7 kb telomeric to gene family member ABCB2 (TAP1). The protein encoded by this gene is involved in antigen presentation. This protein forms a heterodimer with ABCB2 in order to transport peptides from the cytoplasm to the endoplasmic reticulum. Mutations in this gene may be associated with ankylosing spondylitis, insulin-dependent diabetes mellitus, schizophrenia,[8] and celiac disease. Alternative splicing of this gene produces two products which differ in peptide selectivity and level of restoration of surface expression of MHC class I molecules.[9]

See also

[edit]

References

[edit]
  1. ^ a b c ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 GRCh38: Ensembl release 89: ENSG00000204267, ENSG00000206299, ENSG00000228582, ENSG00000206235, ENSG00000225967, ENSG00000237599, ENSG00000223481, ENSG00000232326 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024339 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Bodmer JG, Marsh SG, Albert ED, Bodmer WF, Dupont B, Erlich HA, Mach B, Mayr WR, Parham P, Sasazuki T (Oct 1992). "Nomenclature for factors of the HLA system, 1991. WHO Nomenclature Committee for factors of the HLA system". Tissue Antigens. 39 (4): 161–73. doi:10.1111/j.1399-0039.1992.tb01932.x. PMID 1529427.
  6. ^ Bahram S, Arnold D, Bresnahan M, Strominger JL, Spies T (Dec 1991). "Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region". Proc Natl Acad Sci U S A. 88 (22): 10094–8. Bibcode:1991PNAS...8810094B. doi:10.1073/pnas.88.22.10094. PMC 52874. PMID 1946428.
  7. ^ Hahn Y, Lee B (Feb 2006). "Human-specific nonsense mutations identified by genome sequence comparisons". Hum Genet. 119 (1–2): 169–78. doi:10.1007/s00439-005-0125-6. PMID 16395595. S2CID 21059468.
  8. ^ Yu H (2014). "Protein-interaction-network-based analysis for genome-wide association analysis of schizophrenia in Han Chinese population". Journal of Psychiatric Research. 50: 73–8. doi:10.1016/j.jpsychires.2013.11.014. PMID 24365204.
  9. ^ "Entrez Gene: TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)".

Further reading

[edit]
[edit]

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