HTR3C: Difference between revisions

HTR3C
Identifiers
Aliases	HTR3C, 5-hydroxytryptamine receptor 3C
External IDs	OMIM: 610121; HomoloGene: 50847; GeneCards: HTR3C; OMA:HTR3C - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	184,060,673 bp
RNA expression pattern
	Top expressed in
	testicle; ; right lung; ; mucosa of transverse colon; ; upper lobe of left lung; ; duodenum; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; gallbladder; ; myometrium; ; skin of abdomen;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; extracellular ligand-gated ion channel activity; serotonin-gated cation-selective channel activity; ion channel activity; transmembrane signaling receptor activity;
Cellular component	integral component of membrane; plasma membrane; membrane; integral component of plasma membrane; neuron projection; synapse;
Biological process	ion transport; signal transduction; ion transmembrane transport; serotonin receptor signaling pathway; chemical synaptic transmission; regulation of membrane potential; nervous system process;
	Sources:Amigo / QuickGO
Orthologs
	170572
	n/a
	ENSG00000178084
	n/a
	Q8WXA8
	n/a
	NM_130770
	n/a
	NP_570126
	n/a
	Wikidata
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Latest revision as of 22:12, 3 March 2023

5-hydroxytryptamine receptor 3C is a protein that in humans is encoded by the HTR3C gene.^[3]^[4] The protein encoded by this gene is a subunit of the 5-HT3 receptor.^[4]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000178084 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene. 310: 101–11. doi:10.1016/S0378-1119(03)00503-1. PMID 12801637.
^ ^a ^b Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans. 32 (Pt3): 547–52. doi:10.1042/BST0320547. PMID 15157181.

External links

HTR3C+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This transmembrane receptor-related article is a stub. You can help Wikipedia by expanding it.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000178084 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid12801637-3] Niesler B, Frank B, Kapeller J, Rappold GA (Jun 2003). "Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E". Gene. 310: 101–11. doi:10.1016/S0378-1119(03)00503-1. PMID 12801637.

[pmid15157181-4] Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ (May 2004). "The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance". Biochem Soc Trans. 32 (Pt3): 547–52. doi:10.1042/BST0320547. PMID 15157181.

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@@ Line 1: / Line 1: @@
+{{Short description|Protein-coding gene in the species Homo sapiens}}
-{{PBB|geneid=170572}}
+{{Infobox_gene}}
-'''5-hydroxytryptamine (serotonin) receptor 3C''', also known as '''HTR3C''', is a human [[gene]].<ref name="pmid12801637">{{cite journal | author = Niesler B, Frank B, Kapeller J, Rappold GA | title = Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E | journal = Gene | volume = 310 | issue = | pages = 101–11 | year = 2003 | month = May | pmid = 12801637 | doi = 10.1016/S0378-1119(03)00503-1| url = http://linkinghub.elsevier.com/retrieve/pii/S0378111903005031 | issn = }}</ref>  The protein encoded by this gene is a subunit of the [[5-HT3 receptor]].<ref name="pmid15157181">{{cite journal | author = Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ | title = The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance | journal = Biochem. Soc. Trans. | volume = 32 | issue = Pt3 | pages = 547–52 | year = 2004 | month = June | pmid = 15157181 | doi = 10.1042/BST0320547 | url = | issn = }}</ref>
+'''5-hydroxytryptamine receptor 3C''' is a [[protein]] that in humans is encoded by the ''HTR3C'' [[gene]].<ref name="pmid12801637">{{cite journal |vauthors=Niesler B, Frank B, Kapeller J, Rappold GA | title = Cloning, physical mapping and expression analysis of the human 5-HT3 serotonin receptor-like genes HTR3C, HTR3D and HTR3E | journal = Gene | volume = 310 | pages = 101–11 |date=Jun 2003 | pmid = 12801637 | doi =10.1016/S0378-1119(03)00503-1  }}</ref><ref name="pmid15157181">{{cite journal |vauthors=Peters JA, Kelley SP, Dunlop JI, Kirkness EF, Hales TG, Lambert JJ | title = The 5-hydroxytryptamine type 3 (5-HT3) receptor reveals a novel determinant of single-channel conductance | journal = Biochem Soc Trans | volume = 32 | issue = Pt3 | pages = 547–52 |date=May 2004 | pmid = 15157181 | doi = 10.1042/BST0320547 }}</ref>  The protein encoded by this gene is a subunit of the [[5-HT3 receptor]].<ref name="pmid15157181" />
 ==References==
@@ Line 8: / Line 9: @@
 ==Further reading==
 {{refbegin | 2}}
-*{{cite journal  |author=Karnovsky AM, Gotow LF, McKinley DD, ''et al.'' |title=A cluster of novel serotonin receptor 3-like genes on human chromosome 3. |journal=Gene |volume=319 |issue=  |pages= 137-48 |year= 2003 |pmid= 14597179 |doi=  }}
+*{{cite journal   |vauthors=Karnovsky AM, Gotow LF, McKinley DD, etal |title=A cluster of novel serotonin receptor 3-like genes on human chromosome 3. |journal=Gene |volume=319 |pages= 137–48 |year= 2003 |pmid= 14597179 |doi=10.1016/S0378-1119(03)00803-5  }}
-*{{cite journal  |author=Fasching PA, Kollmannsberger B, Strissel PL, ''et al.'' |title=Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. |journal=J. Cancer Res. Clin. Oncol. |volume=134 |issue= 10 |pages= 1079-86 |year= 2008 |pmid= 18389280 |doi= 10.1007/s00432-008-0387-1 }}
+*{{cite journal   |vauthors=Fasching PA, Kollmannsberger B, Strissel PL, etal |title=Polymorphisms in the novel serotonin receptor subunit gene HTR3C show different risks for acute chemotherapy-induced vomiting after anthracycline chemotherapy. |journal=J. Cancer Res. Clin. Oncol. |volume=134 |issue= 10 |pages= 1079–86 |year= 2008 |pmid= 18389280 |doi= 10.1007/s00432-008-0387-1 |s2cid=7504731 }}
-*{{cite journal  |author=Ward MB, Kotasek D, McKinnon RA |title=Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy. |journal=Pharmacogenomics |volume=9 |issue= 8 |pages= 1027-33 |year= 2008 |pmid= 18681779 |doi= 10.2217/14622416.9.8.1027 }}
+*{{cite journal  |vauthors=Ward MB, Kotasek D, McKinnon RA |title=Investigation of HTR3C mutations for association with 5HT(3) receptor antagonist anti-emetic efficacy. |journal=Pharmacogenomics |volume=9 |issue= 8 |pages= 1027–33 |year= 2008 |pmid= 18681779 |doi= 10.2217/14622416.9.8.1027 }}
 {{refend}}
@@ Line 16: / Line 17: @@
 * {{MeshName|HTR3C+protein,+human}}
-{{transmembranereceptor-stub}}
 {{Ligand-gated ion channels}}
-[[Category:Neurotransmitters]]
+[[Category:Serotonin receptors]]
 [[Category:Ion channels]]
-[[Category:Ionotropic receptors]]
+{{transmembranereceptor-stub}}