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Adding local short description: "Muscle relaxant", overriding Wikidata description "Skeletal Muscle Relaxant"
 
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{{Short description|Muscle relaxant}}
{{Drugbox
{{Drugbox
| Verifiedfields = changed
⚫
| name = Idrocilamide
| Watchedfields = changed
⚫
| IUPAC_name =
| verifiedrevid = 447822894
| image =
| IUPAC_name = ''N''-(2-Hydroxyethyl)-3-phenyl-2-propenamide, N-(2 hydroxyethyl)cinnamamide

⚫
| image = Idrocilamide.png
| width =
| width =
| alt =
| alt =
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| width2 =
| width2 =
| alt2 =
| alt2 =
| imagename = <!-- else may use drug_name -->
| caption =
| drug_name = <!-- else may use imagename -->
| caption =


<!--Clinical data-->
<!--Clinical data-->
| tradename =
| tradename = Talval, Srilane, Relaxnova, Brolitène
| Drugs.com =
| Drugs.com = {{Drugs.com|international|idrocilamide}}
| MedlinePlus =
| MedlinePlus =
| licence_EU = <!-- EMA requires brand name -->
| licence_EU = <!-- EMA requires brand name -->
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| legal_status =
| legal_status =
| dependency_liability =
| dependency_liability =
| routes_of_administration =
| routes_of_administration = [[Topical]]


<!--Pharmacokinetic data-->
<!--Pharmacokinetic data-->
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| metabolism =
| metabolism =
| elimination_half-life =
| elimination_half-life =
| excretion =
| excretion =


<!--Identifiers-->
<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 6961-46-2
| CAS_number = 6961-46-2
| CAS_supplemental =
| CAS_supplemental =
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| ATC_suffix = AX05
| ATC_suffix = AX05
| ATC_supplemental =
| ATC_supplemental =
| PubChem =
| PubChem = 1550874
| PubChemSubstance =
| PubChemSubstance =
| IUPHAR_ligand =
| IUPHAR_ligand =
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =
| DrugBank =
| ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}}
| ChemSpiderID =
| ChemSpiderID = 1267352
| UNII =
| smiles = O=C(\C=C\c1ccccc1)NCCO
| StdInChI_Ref = {{stdinchicite|changed|chemspider}}
| StdInChI = 1S/C11H13NO2/c13-9-8-12-11(14)7-6-10-4-2-1-3-5-10/h1-7,13H,8-9H2,(H,12,14)/b7-6+
| StdInChIKey_Ref = {{stdinchicite|changed|chemspider}}
| StdInChIKey = OSCTXCOERRNGLW-VOTSOKGWSA-N
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 6C816LUB1O
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG =
| KEGG =
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI =
| ChEBI =
| ChEMBL_Ref = {{ebicite|changed|EBI}}
| ChEMBL =
⚫
| ChEMBL = 102358


<!--Chemical data-->
<!--Chemical data-->
| C=11 | H=13 | N=1 | O=2
| C=11 | H=13 | N=1 | O=2
| molecular_weight = 191
| smiles =
| StdInChI =
| StdInChI_comment =
| StdInChIKey =
| synonyms =
| synonyms =
| density =
| density =
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}}
}}


'''Idrocilamide''' ('''Relaxnova''', '''Srilane''', '''Talval''') is a [[muscle relaxant]].
'''Idrocilamide''' (trade names '''Talval''', '''Srilane''', '''Relaxnova''', '''Brolitène'''<ref name="Drugs.com">Drugs.com: {{Drugs.com|international|idrocilamide}}</ref>) is a [[medication]] with skeletal muscle relaxant<ref>
{{Cite journal
|vauthors=Bouron A, Rivet M, Nasri-Sebdani M, Guillemain J, Durbin P, Guerrier D, Raymond G
|year=1990
|title=The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers
|journal=[[Canadian Journal of Physiology and Pharmacology]]
|volume=68 |issue=12 |pages=1503–1509
|doi=10.1139/y90-228
|pmid=2085796
}}</ref> and anti-inflammatory actions<ref name=pmid8012322>
{{cite journal
|vauthors=Bannwarth B, Le Huec JC, Vinçon G, Labat L, Demotes-Mainard F, Rivaille F, Le Rebeller A
|year=1993
|title=[Tissue and systemic diffusion of idrocilamide after cutaneous administration]
|language=French
|journal=[[Revue du Rhumatisme]]
|volume=60 |issue=12 |pages=932–6
|pmid=8012322
|doi=
}}</ref> used as a topical cream to treat [[lumbago]] and other kinds of [[myalgia|muscular pain]];<ref>
{{Cite journal
|vauthors=Stehman M, Lehert P
|year=1990
|title=Clinical double-blind study with idrocilamide ointment in the treatment of acute lumbago
|journal=[[Acta Belgica. Medica Physica]]
|volume=13 |issue=1 |pages=29–32
|pmid=2140002
}}</ref> it is available on prescription or over-the-counter{{citation needed|date=June 2012}} in France and various other countries.<ref name="Drugs.com" />

==Interactions==
Idrocilamide has been reported to be a potent inhibitor of the metabolism of caffeine.<ref name=pmid10976659>
{{cite journal
|vauthors=Carrillo JA, Benitez J
|year=2000
|title=Clinically significant pharmacokinetic interactions between dietary caffeine and medications
|journal=[[Clinical Pharmacokinetics]]
|volume=39 |issue=2 |pages=127–53
|doi=10.2165/00003088-200039020-00004
|pmid=10976659
}}</ref><ref name=pmid7371698>
{{cite journal
|vauthors=Brazier JL, Descotes J, Lery N, Ollagnier M, Evreux JC
|date=1980
|title=Inhibition by idrocilamide of the disposition of caffeine
|journal=[[European Journal of Clinical Pharmacology]]
|volume=17 |issue=1 |pages=37–43
|doi=10.1007/bf00561675
|pmid=7371698
}}</ref>
==References==
{{reflist}}

{{Topical products for joint and muscular pain}}

[[Category:Drugs acting on the musculoskeletal system]]
⚫
[[Category:Carboxamides]]



{{Musculoskeletal-drug-stub}}
⚫
[[Category:Muscle relaxants]]

Latest revision as of 15:08, 31 January 2023

Idrocilamide
Clinical data
Trade namesTalval, Srilane, Relaxnova, Brolitène
AHFS/Drugs.comInternational Drug Names
Routes of
administration		Topical
ATC code
Identifiers
  • N-(2-Hydroxyethyl)-3-phenyl-2-propenamide, N-(2 hydroxyethyl)cinnamamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
CompTox Dashboard (EPA)
ECHA InfoCard100.027.414 Edit this at Wikidata
Chemical and physical data
FormulaC11H13NO2
Molar mass191.230 g·mol−1
3D model (JSmol)
  • O=C(\C=C\c1ccccc1)NCCO
  • InChI=1S/C11H13NO2/c13-9-8-12-11(14)7-6-10-4-2-1-3-5-10/h1-7,13H,8-9H2,(H,12,14)/b7-6+ ☒N
  • Key:OSCTXCOERRNGLW-VOTSOKGWSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Idrocilamide (trade names Talval, Srilane, Relaxnova, Brolitène[1]) is a medication with skeletal muscle relaxant[2] and anti-inflammatory actions[3] used as a topical cream to treat lumbago and other kinds of muscular pain;[4] it is available on prescription or over-the-counter[citation needed] in France and various other countries.[1]

Interactions

[edit]

Idrocilamide has been reported to be a potent inhibitor of the metabolism of caffeine.[5][6]

References

[edit]
  1. ^ a b Drugs.com: International Drug Names
  2. ^ Bouron A, Rivet M, Nasri-Sebdani M, Guillemain J, Durbin P, Guerrier D, Raymond G (1990). "The direct depressant effect of LCB29 (idrocilamide) on mechanical tension of rat soleus muscle fibers". Canadian Journal of Physiology and Pharmacology. 68 (12): 1503–1509. doi:10.1139/y90-228. PMID 2085796.
  3. ^ Bannwarth B, Le Huec JC, Vinçon G, Labat L, Demotes-Mainard F, Rivaille F, Le Rebeller A (1993). "[Tissue and systemic diffusion of idrocilamide after cutaneous administration]". Revue du Rhumatisme (in French). 60 (12): 932–6. PMID 8012322.
  4. ^ Stehman M, Lehert P (1990). "Clinical double-blind study with idrocilamide ointment in the treatment of acute lumbago". Acta Belgica. Medica Physica. 13 (1): 29–32. PMID 2140002.
  5. ^ Carrillo JA, Benitez J (2000). "Clinically significant pharmacokinetic interactions between dietary caffeine and medications". Clinical Pharmacokinetics. 39 (2): 127–53. doi:10.2165/00003088-200039020-00004. PMID 10976659.
  6. ^ Brazier JL, Descotes J, Lery N, Ollagnier M, Evreux JC (1980). "Inhibition by idrocilamide of the disposition of caffeine". European Journal of Clinical Pharmacology. 17 (1): 37–43. doi:10.1007/bf00561675. PMID 7371698.


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